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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

31.03.2023 | Original Paper

A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive–compulsive disorder

verfasst von: Zibin Yang, Shu Xiao, Ting Su, Jiayin Gong, Zhangzhang Qi, Guanmao Chen, Pan Chen, Guixian Tang, SiYing Fu, Hong Yan, Li Huang, Ying Wang

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 1/2024

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Abstract

Numerous neuroimaging studies of resting-state functional imaging and voxel-based morphometry (VBM) have revealed abnormalities in specific brain regions in obsessive–compulsive disorder (OCD), but results have been inconsistent. We conducted a whole-brain voxel-wise meta-analysis on resting-state functional imaging and VBM studies that investigated differences of functional activity and gray matter volume (GMV) between patients with OCD and healthy controls (HCs) using seed-based d mapping (SDM) software. A total of 41 independent studies (51 datasets) for resting-state functional imaging and 42 studies (46 datasets) for VBM were included by a systematic literature search. Overall, patients with OCD displayed increased spontaneous functional activity in the bilateral inferior frontal gyrus (IFG) (extending to the bilateral insula) and bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), as well as decreased spontaneous functional activity in the bilateral paracentral lobule, bilateral cerebellum, left caudate nucleus, left inferior parietal gyri, and right precuneus cortex. For the VBM meta-analysis, patients with OCD displayed increased GMV in the bilateral thalamus (extending to the bilateral cerebellum), right striatum, and decreased GMV in the bilateral mPFC/ACC and left IFG (extending to the left insula). The conjunction analyses found that the bilateral mPFC/ACC, left IFG (extending to the left insula) showed decreased GMV with increased intrinsic function in OCD patients compared to HCs. This meta-analysis demonstrated that OCD exhibits abnormalities in both function and structure in the bilateral mPFC/ACC, insula, and IFG. A few regions exhibited only functional or only structural abnormalities in OCD, such as the default mode network, striatum, sensorimotor areas, and cerebellum. It may provide useful insights for understanding the underlying pathophysiology of OCD and developing more targeted and efficacious treatment and intervention strategies.

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Titel: A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive–compulsive disorder
verfasst von: Zibin Yang
Shu Xiao
Ting Su
Jiayin Gong
Zhangzhang Qi
Guanmao Chen
Pan Chen
Guixian Tang
SiYing Fu
Hong Yan
Li Huang
Ying Wang
Publikationsdatum: 31.03.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2024
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-023-01594-x

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A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive–compulsive disorder

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