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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

30.10.2022 | Original Paper

Cognitive and clinical characteristics of offenders and non-offenders diagnosed with schizophrenia spectrum disorders: results of the Recoviwel observational study

verfasst von: Stefano Barlati, Gabriele Nibbio, Valentina Stanga, Giulia Giovannoli, Irene Calzavara-Pinton, Nicola Necchini, Jacopo Lisoni, Giacomo Deste, Antonio Vita

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 6/2023

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Abstract

The association between schizophrenia spectrum disorders (SSD) and violent behavior is complex and requires further research. The cognitive correlates of violent behavior, in particular, remain to be further investigated. Aims of the present study were to comprehensively assess the cognitive and clinical profile of SSD violent offenders and evaluate individual predictors of violent behavior. Fifty inmates convicted for violent crimes in a forensic psychiatry setting and diagnosed with SSD were compared to fifty non-offender patients matched for age, gender, education, and diagnosis. Offender and non-offender participants were compared based on socio-demographic, clinical, and cognitive variables using non-parametric testing to select potential predictors of violent behavior. Multivariate logistic regressions were then performed to identify individual predictors of violent behavior. Offender participants showed more school failures, higher prevalence of substance use, higher Clinical Global Impression Severity Scale (CGI-S) and Positive and Negative Syndrome Scale Excited Component (PANSS-EC) scores, worse working memory and better attention performance, higher Historical Clinical and Risk Management scale 20 (HCR-20) and Hare Psychopathy Checklist (PCL-R) scores in all subdomains and factors. School failures, higher PANSS-EC scores, worse working memory and processing speed, better attention performance, higher scores in HCR-20 Management subscale and the PCL-R “Callous” factor emerged as predictors of violent behavior. Better attentional performance was correlated with higher PCL-R “Callous” factor scores, worse cognitive performance in several domains with higher PCL-R “Unstable” factor scores. In conclusion, the present study highlights the importance of carefully assessing SSD patients with violent behavior in all clinical, cognitive, and behavioral aspects.

Caruso R, Antenora F, Riba M et al (2021) Aggressive behavior and psychiatric inpatients: a narrative review of the literature with a focus on the European experience. Curr Psychiatry Rep 23:29. https://doi.org/10.1007/s11920-021-01233-zCrossRefPubMedPubMedCentral

Whiting D, Lichtenstein P, Fazel S (2021) Violence and mental disorders: a structured review of associations by individual diagnoses, risk factors, and risk assessment. Lancet Psychiatry 8:150–161. https://doi.org/10.1016/S2215-0366(20)30262-5CrossRefPubMed

Brekke JS, Prindle C, Bae SW, Long JD (2001) Risks for individuals with schizophrenia who are living in the community. Psychiatr Serv Wash DC 52:1358–1366. https://doi.org/10.1176/appi.ps.52.10.1358CrossRef

Fazel S, Sariaslan A (2021) Victimization in people with severe mental health problems: the need to improve research quality, risk stratification and preventive measures. World Psychiatry 20:437–438. https://doi.org/10.1002/wps.20908CrossRefPubMedPubMedCentral

Barlati S, Morena D, Nibbio G et al (2021) Internalized stigma among people with schizophrenia: Relationship with socio-demographic, clinical and medication-related features. Schizophr Res. https://doi.org/10.1016/j.schres.2021.06.007CrossRefPubMed

Latalova K, Kamaradova D, Prasko J (2014) Violent victimization of adult patients with severe mental illness: a systematic review. Neuropsychiatr Dis Treat 10:1925–1939. https://doi.org/10.2147/NDT.S68321CrossRefPubMedPubMedCentral

Maniglio R (2009) Severe mental illness and criminal victimization: a systematic review. Acta Psychiatr Scand 119:180–191. https://doi.org/10.1111/j.1600-0447.2008.01300.xCrossRefPubMed

Rossa-Roccor V, Schmid P, Steinert T (2020) Victimization of people with severe mental illness outside and within the mental health care system: results on prevalence and risk factors from a multicenter study. Front Psychiatry 11:932. https://doi.org/10.3389/fpsyt.2020.563860CrossRef

Barlati S, Stefana A, Bartoli F et al (2019) Violence risk and mental disorders (VIORMED-2): a prospective multicenter study in Italy. PLoS ONE 14:e0214924. https://doi.org/10.1371/journal.pone.0214924CrossRefPubMedPubMedCentral

10.

Iozzino L, Ferrari C, Large M et al (2015) Prevalence and risk factors of violence by psychiatric acute inpatients: a systematic review and meta-analysis. PLoS ONE 10:e0128536. https://doi.org/10.1371/journal.pone.0128536CrossRefPubMedPubMedCentral

11.

Sariaslan A, Arseneault L, Larsson H et al (2020) Risk of subjection to violence and perpetration of violence in persons with psychiatric disorders in Sweden. JAMA Psychiat 77:359–367. https://doi.org/10.1001/jamapsychiatry.2019.4275CrossRef

12.

Fazel S, Gulati G, Linsell L et al (2009) Schizophrenia and violence: systematic review and meta-analysis. PLoS Med 6:e1000120. https://doi.org/10.1371/journal.pmed.1000120CrossRefPubMedPubMedCentral

13.

Stevens H, Laursen TM, Mortensen PB et al (2015) Post-illness-onset risk of offending across the full spectrum of psychiatric disorders. Psychol Med 45:2447–2457. https://doi.org/10.1017/S0033291715000458CrossRefPubMed

14.

Duke AA, Smith KMZ, Oberleitner LMS et al (2018) Alcohol, drugs, and violence: a meta-meta-analysis. Psychol Violence 8:238–249. https://doi.org/10.1037/vio0000106CrossRef

15.

Van Dorn R, Volavka J, Johnson N (2012) Mental disorder and violence: is there a relationship beyond substance use? Soc Psychiatry Psychiatr Epidemiol 47:487–503. https://doi.org/10.1007/s00127-011-0356-xCrossRefPubMed

16.

Fazel S, Smith EN, Chang Z, Geddes JR (2018) Risk factors for interpersonal violence: an umbrella review of meta-analyses. Br J Psychiatry J Ment Sci 213:609–614. https://doi.org/10.1192/bjp.2018.145CrossRef

17.

Lamsma J, Cahn W, Fazel S, GROUP and NEDEN investigators (2020) Use of illicit substances and violent behaviour in psychotic disorders: two nationwide case-control studies and meta-analyses. Psychol Med 50:2028–2033. https://doi.org/10.1017/S0033291719002125CrossRefPubMed

18.

Bo S, Abu-Akel A, Kongerslev M et al (2011) Risk factors for violence among patients with schizophrenia. Clin Psychol Rev 31:711–726. https://doi.org/10.1016/j.cpr.2011.03.002CrossRefPubMed

19.

Fazel S, Wolf A, Larsson H et al (2017) Identification of low risk of violent crime in severe mental illness with a clinical prediction tool (Oxford Mental Illness and Violence tool [OxMIV]): a derivation and validation study. Lancet Psychiatry 4:461–468. https://doi.org/10.1016/S2215-0366(17)30109-8CrossRefPubMedPubMedCentral

20.

Fleischman A, Werbeloff N, Yoffe R et al (2014) Schizophrenia and violent crime: a population-based study. Psychol Med 44:3051–3057. https://doi.org/10.1017/S0033291714000695CrossRefPubMed

21.

Jeyagurunathan A, Lau JH, Abdin E et al (2022) Aggression amongst outpatients with schizophrenia and related psychoses in a tertiary mental health institution. Front Psychiatry. https://doi.org/10.3389/fpsyt.2021.777388CrossRefPubMedPubMedCentral

22.

Witt K, van Dorn R, Fazel S (2013) Risk factors for violence in psychosis: systematic review and meta-regression analysis of 110 studies. PLoS ONE 8:e55942. https://doi.org/10.1371/journal.pone.0055942CrossRefPubMedPubMedCentral

23.

Galderisi S, Rossi A, Rocca P et al (2014) The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia. World Psychiatry 13:275–287. https://doi.org/10.1002/wps.20167CrossRefPubMedPubMedCentral

24.

Green MF, Horan WP, Lee J (2019) Nonsocial and social cognition in schizophrenia: current evidence and future directions. World Psychiatry 18:146–161. https://doi.org/10.1002/wps.20624CrossRefPubMedPubMedCentral

25.

Harvey PD, Strassnig M (2012) Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status. World Psychiatry 11:73–79. https://doi.org/10.1016/j.wpsyc.2012.05.004CrossRefPubMedPubMedCentral

26.

Vita A, Gaebel W, Mucci A et al (2022) EPA Guidance on treatment of cognitive impairment in schizophrenia. Eur Psychiatry. https://doi.org/10.1192/j.eurpsy.2022.2315CrossRefPubMedPubMedCentral

27.

Reinharth J, Reynolds G, Dill C, Serper M (2014) Cognitive predictors of violence in schizophrenia: a meta-analytic review. Schizophr Res Cogn 1:101–111. https://doi.org/10.1016/j.scog.2014.06.001CrossRef

28.

Ahmed AO, Richardson J, Buckner A et al (2018) Do cognitive deficits predict negative emotionality and aggression in schizophrenia? Psychiatry Res 259:350–357. https://doi.org/10.1016/j.psychres.2017.11.003CrossRefPubMed

29.

Rund BR (2018) A review of factors associated with severe violence in schizophrenia. Nord J Psychiatry 72:561–571. https://doi.org/10.1080/08039488.2018.1497199CrossRefPubMed

30.

Bulgari V, Iozzino L, Ferrari C et al (2017) Clinical and neuropsychological features of violence in schizophrenia: a prospective cohort study. Schizophr Res 181:124–130. https://doi.org/10.1016/j.schres.2016.10.016CrossRefPubMed

31.

Keefe RSE, Harvey PD (2012) Cognitive impairment in schizophrenia. Handb Exp Pharmacol. https://doi.org/10.1007/978-3-642-25758-2_2CrossRefPubMed

32.

Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276. https://doi.org/10.2466/pms.1958.8.3.271CrossRef

33.

Stroop JR (1938) Factors affecting speed in serial verbal reactions. Psychol Monogr 50:38–48. https://doi.org/10.1037/h0093516CrossRef

34.

Fusar-Poli P, Deste G, Smieskova R et al (2012) Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry 69:562–571. https://doi.org/10.1001/archgenpsychiatry.2011.1592CrossRefPubMed

35.

Vita A, Barlati S, Ceraso A et al (2021) Effectiveness, core elements, and moderators of response of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiat 78:848–858. https://doi.org/10.1001/jamapsychiatry.2021.0620CrossRef

36.

Kerr SL, Neale JM (1993) Emotion perception in schizophrenia: specific deficit or further evidence of generalized poor performance? J Abnorm Psychol 102:312–318. https://doi.org/10.1037//0021-843x.102.2.312CrossRefPubMed

37.

Guy W (1976) ECDEU assessment manual for psychopharmacology. U.S. Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs

38.

Kay SR, Fiszbein A, Opler LA (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276. https://doi.org/10.1093/schbul/13.2.261CrossRefPubMed

39.

Montoya A, Valladares A, Lizán L et al (2011) Validation of the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC) in a naturalistic sample of 278 patients with acute psychosis and agitation in a psychiatric emergency room. Health Qual Life Outcomes 9:18. https://doi.org/10.1186/1477-7525-9-18CrossRefPubMedPubMedCentral

40.

Patton JH, Stanford MS, Barratt ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51:768–774. https://doi.org/10.1002/1097-4679(199511)51:6%3c768::aid-jclp2270510607%3e3.0.co;2-1CrossRefPubMed

41.

Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–15. https://doi.org/10.1016/0010-0277(94)90018-3CrossRefPubMed

42.

Kay SR, Wolkenfeld F, Murrill LM (1988) Profiles of aggression among psychiatric patients: I. Nature and prevalence. J Nerv Ment Dis 176:539–546. https://doi.org/10.1097/00005053-198809000-00007CrossRefPubMed

43.

Douglas KS, Webster CD (1999) The HCR-20 violence risk assessment scheme: concurrent validity in a sample of incarcerated offenders. Crim Justice Behav 26:3–19. https://doi.org/10.1177/0093854899026001001CrossRef

44.

Hare RD (2003) The psychopathy checklist—revised manual. Tor Ont Can MHS

45.

Hare RD (2020) The PCL-R assessment of psychopathy. The Wiley International handbook on psychopathic disorders and the law. John Wiley & Sons Ltd, pp 63–106CrossRef

46.

Heinze G, Wallisch C, Dunkler D (2018) Variable selection – a review and recommendations for the practicing statistician. Biom J Biom Z 60:431–449. https://doi.org/10.1002/bimj.201700067CrossRef

47.

Midi H, Sarkar SK, Rana S (2010) Collinearity diagnostics of binary logistic regression model. J Interdiscip Math 13:253–267. https://doi.org/10.1080/09720502.2010.10700699CrossRef

48.

Peduzzi P, Concato J, Kemper E et al (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49:1373–1379. https://doi.org/10.1016/s0895-4356(96)00236-3CrossRefPubMed

49.

Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165:710–718. https://doi.org/10.1093/aje/kwk052CrossRefPubMed

50.

Erskine HE, Norman RE, Ferrari AJ et al (2016) Long-term outcomes of attention-deficit/hyperactivity disorder and conduct disorder: a systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 55:841–850. https://doi.org/10.1016/j.jaac.2016.06.016CrossRefPubMed

51.

Valsecchi P, Nibbio G, Rosa J et al (2021) Adult ADHD: prevalence and clinical correlates in a sample of Italian psychiatric outpatients. J Atten Disord 25:530–539. https://doi.org/10.1177/1087054718819824CrossRefPubMed

52.

Slotboom J, Hoppenbrouwers SS, Bouman YHA et al (2017) Visual attention in violent offenders: susceptibility to distraction. Psychiatry Res 251:281–286. https://doi.org/10.1016/j.psychres.2017.02.031CrossRefPubMed

53.

Maj M, van Os J, De Hert M et al (2021) The clinical characterization of the patient with primary psychosis aimed at personalization of management. World Psychiatry 20:4–33. https://doi.org/10.1002/wps.20809CrossRefPubMedPubMedCentral

54.

Morin L, Franck N (2017) Rehabilitation interventions to promote recovery from schizophrenia: a systematic review. Front Psychiatry. https://doi.org/10.3389/fpsyt.2017.00100CrossRefPubMedPubMedCentral

55.

Nibbio G, Barlati S, Cacciani P et al (2020) Evidence-based integrated intervention in patients with schizophrenia: a pilot study of feasibility and effectiveness in a real-world rehabilitation setting. Int J Environ Res Public Health 17:E3352. https://doi.org/10.3390/ijerph17103352CrossRef

56.

Vita A, Barlati S, Ceraso A et al (2022) Acceptability of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized controlled trials. Psychol Med. https://doi.org/10.1017/S0033291722000319CrossRefPubMedPubMedCentral

57.

Firth J, Stubbs B, Rosenbaum S et al (2017) Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull 43:546–556. https://doi.org/10.1093/schbul/sbw115CrossRefPubMed

58.

Stubbs B, Vancampfort D, Hallgren M et al (2018) EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH). Eur Psychiatry J Assoc Eur Psychiatr 54:124–144. https://doi.org/10.1016/j.eurpsy.2018.07.004CrossRef

59.

Vita A, De Peri L, Barlati S et al (2011) Psychopathologic, neuropsychological and functional outcome measures during cognitive rehabilitation in schizophrenia: A prospective controlled study in a real-world setting. Eur Psychiatry 26:276–283. https://doi.org/10.1016/j.eurpsy.2010.03.008CrossRefPubMed

60.

Ahmed AO, Hunter KM, Goodrum NM et al (2015) A randomized study of cognitive remediation for forensic and mental health patients with schizophrenia. J Psychiatr Res 68:8–18. https://doi.org/10.1016/j.jpsychires.2015.05.013CrossRefPubMed

61.

O’Reilly K, Donohoe G, O’Sullivan D et al (2019) A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder. BMC Psychiatry 19:27. https://doi.org/10.1186/s12888-019-2018-6CrossRefPubMedPubMedCentral

62.

Thomas ML, Bismark AW, Joshi YB et al (2018) Targeted cognitive training improves auditory and verbal outcomes among treatment refractory schizophrenia patients mandated to residential care. Schizophr Res 202:378–384. https://doi.org/10.1016/j.schres.2018.07.025CrossRefPubMedPubMedCentral

63.

Tengström A, Hodgins S, Kullgren G (2001) Men with schizophrenia who behave violently: the usefulness of an early- versus late-start offender typology. Schizophr Bull 27:205–218. https://doi.org/10.1093/oxfordjournals.schbul.a006867CrossRefPubMed

64.

Galderisi S, Mucci A, Dollfus S et al (2021) EPA guidance on assessment of negative symptoms in schizophrenia. Eur Psychiatry 64:e23. https://doi.org/10.1192/j.eurpsy.2021.11CrossRefPubMedPubMedCentral

Titel: Cognitive and clinical characteristics of offenders and non-offenders diagnosed with schizophrenia spectrum disorders: results of the Recoviwel observational study
verfasst von: Stefano Barlati
Gabriele Nibbio
Valentina Stanga
Giulia Giovannoli
Irene Calzavara-Pinton
Nicola Necchini
Jacopo Lisoni
Giacomo Deste
Antonio Vita
Publikationsdatum: 30.10.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 6/2023
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-022-01510-9

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