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Journal of Neurology

Erschienen in:

16.06.2023 | Review

Comorbidity of epilepsy and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis

verfasst von: Shun Wang, Baozhen Yao, Haiju Zhang, Liping Xia, Shiqian Yu, Xia Peng, Dan Xiang, Zhongchun Liu

Erschienen in: Journal of Neurology | Ausgabe 9/2023

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Abstract

Epilepsy and attention-deficit/hyperactivity disorder (ADHD) are common neurological and neuropsychiatric disorders, respectively, that can exist as comorbidities. However, the degree of comorbidity between both disorders has never been quantified based on a systematic review with meta-analysis. We performed a systematic search of the literature in Embase, PubMed, PsychINFO and the Cochrane Library on June 20, 2022. In a meta-analysis of 63 studies with a total sample size of 1,073,188 individuals (172,206 with epilepsy and 900,982 with ADHD) from 17 countries, the pooled prevalence of ADHD in epilepsy was 22.3% (95% CI 20.3–24.4%). The highest pooled prevalence was 12.7% (95% CI 9–17.1%) for ADHD-I subtype, whereas the pooled prevalence of epilepsy in ADHD was 3.4% (95% CI 2.53–4.21%). However, substantial heterogeneity in comorbidity rates was observed and partially attributed to the following factors: sample size, sample specification, geographical variations and diagnostic methods. Our study highlights the need for increased awareness of this diagnostic co-occurrence, and research is warranted to elucidate the underlying pathophysiological mechanisms.

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Titel: Comorbidity of epilepsy and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis
verfasst von: Shun Wang
Baozhen Yao
Haiju Zhang
Liping Xia
Shiqian Yu
Xia Peng
Dan Xiang
Zhongchun Liu
Publikationsdatum: 16.06.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 9/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11794-z

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