Erschienen in:
19.01.2023 | COVID-19 | Original Article
Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID-19 Patients
verfasst von:
Rogério Pezato, Andrea Goldwasser David, Alexandre Coelho Boggi, Bruna Melo, Claudia Maria Valete Rosalino, Athenea Pascual Rodriguez, Andrew Thamboo, Richard Louis Voegels
Erschienen in:
Indian Journal of Otolaryngology and Head & Neck Surgery
|
Ausgabe 2/2023
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Abstract
Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1 with dyspnea when compared to the control group (p = 0.032) and also when compared to patients who were infected were not dyspneic (p = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.