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Graefe's Archive for Clinical and Experimental Ophthalmology

Erschienen in:

14.08.2023 | Low Vision

Cutoff values of axial length/corneal radius ratio for determining myopia vary with age among 3–18 years old children and adolescents

verfasst von: Shang Liu, Jun Chen, Jingjing Wang, Zhuoting Zhu, Junyao Zhang, Bo Zhang, Jinliuxing Yang, Linlin Du, Jianfeng Zhu, Haidong Zou, Xiangui He, Xun Xu

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 2/2024

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Abstract

Purpose

To investigate the effectiveness and cutoffs of axial length/corneal radius (AL/CR) ratio for myopia detection in children by age.

Methods

Totally, 21 kindergartens and schools were enrolled. Non-cycloplegic autorefraction (NCAR), axial length (AL), horizontal and vertical meridian of corneal radius (CR1, CR2), and cycloplegic autorefraction were measured. Receiver operating characteristic (ROC) curve was used to obtain the effectiveness and cutoff for myopia detection.

Results

Finally, 7803 participants aged 3–18 years with mean AL/CR ratio of 2.99 ± 0.16 were included. Area under the ROC curve (AUC) of AL/CR ratio for myopia detection (0.958 for AL/CR1, 0.956 for AL/CR2, 0.961 for AL/CR) was significantly larger than that of AL (0.919, all P < 0.001), while AUCs of the three were similar with different cutoffs (> 2.98, > 3.05, and > 3.02). When divided by age, the ROC curves of AL/CR ratio in 3- to 5-year-olds showed no significance or low accuracy (AUCs ≤ 0.823) in both genders. In ≥ 6-year-olds, the accuracies were promising (AUCs ≥ 0.883, all P < 0.001), the cutoffs basically increased with age (from > 2.93 in 6-year-olds to > 3.07 in 18-year-olds among girls, and from > 2.96 in 6-year-olds to > 3.07 in 18-year-olds among boys). In addition, boys presented slightly larger cutoffs than girls in all ages except for 16 and 18 years old. For children aged 3–5 years, AL/CR ratio or AL combined with NCAR increased AUC to > 0.900.

Conclusion

AL/CR ratio provided the best prediction of myopia with age-dependent cutoff values for all but preschool children, and the cutoffs of boys were slightly larger than those of girls. For preschool children, AL/CR ratio or AL combined with NCAR is recommended to achieve satisfactory accuracy. AL/CR ratio calculated by two meridians showed similar predictive power but with different cutoffs.

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Titel: Cutoff values of axial length/corneal radius ratio for determining myopia vary with age among 3–18 years old children and adolescents
verfasst von: Shang Liu
Jun Chen
Jingjing Wang
Zhuoting Zhu
Junyao Zhang
Bo Zhang
Jinliuxing Yang
Linlin Du
Jianfeng Zhu
Haidong Zou
Xiangui He
Xun Xu
Publikationsdatum: 14.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 2/2024
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06176-0

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Cutoff values of axial length/corneal radius ratio for determining myopia vary with age among 3–18 years old children and adolescents

Abstract

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