Metastasis of cutaneous melanoma to the eye is rare and has a very poor survival prognosis. The uvea has been found to harbour the majority of intraocular cutaneous melanoma, with choroidal involvement occurring in more than half of the cases [
3]. Isolated vitreous metastases are exceedingly rare with only a few cases reported in the literature [
4]. Different treatments have been reported for its management, with radiotherapy the most frequent. Other options include enucleation or evisceration, vitrectomy, subconjunctival chemotherapy, laser photocoagulation and cryotherapy [
3]. We used one of the drugs approved for the treatment of metastatic cutaneous melanoma, dabrafenib. To our knowledge there are no published reports on the use of dabrafenib for cutaneous melanoma with intraocular metastasis. We postulate that dabrafenib penetrates the blood-retinal barrier well since it achieved a complete resolution of vitreous infiltration in our case. Interestingly, a good penetration of the blood-brain barrier by this drug has been suggested due to its high clinical activity for central nervous system metastasis of cutaneous melanoma in a clinical trial [
5]. Uveitis is a well-known secondary effect of BRAF inhibitors. We recently described a series of patients with uveitis secondary to vemurafenib that resolved with local steroids and temporary withdrawal of vemurafenib [
6]. Our case developed a severe anterior uveitis which also responded to topical steroids. Typically uveitis secondary to BRAF inhibitors is bilateral and our case was unilateral. One potential mechanism for the origin of the uveitis after BRAF inhibitor use is a direct action on intraocular metastatic cells [
2]. This may explain why our patient presented with unilateral uveitis involving only the infiltrated non-vitrectomised eye.
In conclusion, the known efficacy of dabrafenib for treating metastatic disease of cutaneous melanoma replicated when the metastasis involved the vitreous. This might be a safe and effective alternative for managing this infrequent type of metastasis.