Skip to main content

18.03.2024 | REVIEW

Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance

verfasst von: Shabnam Malik, Mohammed Sikander, Mohd Wahid, Anupam Dhasmana, Maryam Sarwat, Sheema Khan, Everardo Cobos, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Erschienen in: Cancer and Metastasis Reviews

Einloggen, um Zugang zu erhalten

Abstract

There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression and treatment resistance. One molecule that has recently emerged in these mechanisms is MUC13 mucin, a transmembrane glycoprotein. Researchers have begun to unravel the molecular complexity of MUC13 and its impact on cancer biology. Studies have shown that MUC13 overexpression can disrupt normal cellular polarity, leading to the acquisition of malignant traits. Furthermore, MUC13 has been associated with increased cancer plasticity, allowing cells to undergo epithelial-mesenchymal transition (EMT) and metastasize. Notably, MUC13 has also been implicated in the development of chemoresistance, rendering cancer cells less responsive to traditional treatment options. Understanding the precise role of MUC13 in cellular plasticity, and chemoresistance could pave the way for the development of targeted therapies to combat cancer progression and enhance treatment efficacy.
Literatur
1.
Zurück zum Zitat Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71, 209–249. https://doi.org/10.3322/caac.21660CrossRefPubMed Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71, 209–249. https://​doi.​org/​10.​3322/​caac.​21660CrossRefPubMed
7.
Zurück zum Zitat Harris, L. N., Broadwater, G., Lin, N. U., Miron, A., Schnitt, S. J., Cowan, D., Lara, J., Bleiweiss, I., Berry, D., Ellis, M., et al. (2006). Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: Results from CALGB 9342. Breast Cancer Research, 8, R66. https://doi.org/10.1186/bcr1622CrossRefPubMedPubMedCentral Harris, L. N., Broadwater, G., Lin, N. U., Miron, A., Schnitt, S. J., Cowan, D., Lara, J., Bleiweiss, I., Berry, D., Ellis, M., et al. (2006). Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: Results from CALGB 9342. Breast Cancer Research, 8, R66. https://​doi.​org/​10.​1186/​bcr1622CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Vulsteke, C., Pfeil, A. M., Schwenkglenks, M., Pettengell, R., Szucs, T. D., Lambrechts, D., Peeters, M., van Dam, P., Dieudonné, A. S., Hatse, S., et al. (2014). Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel. Breast Cancer Research and Treatment, 147, 557–570. https://doi.org/10.1007/s10549-014-3105-5CrossRefPubMed Vulsteke, C., Pfeil, A. M., Schwenkglenks, M., Pettengell, R., Szucs, T. D., Lambrechts, D., Peeters, M., van Dam, P., Dieudonné, A. S., Hatse, S., et al. (2014). Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel. Breast Cancer Research and Treatment, 147, 557–570. https://​doi.​org/​10.​1007/​s10549-014-3105-5CrossRefPubMed
12.
Zurück zum Zitat Sládek, N. E., Kollander, R., Sreerama, L., & Kiang, D. T. (2002). Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemotherapy and Pharmacology, 49, 309–321. https://doi.org/10.1007/s00280-001-0412-4CrossRefPubMed Sládek, N. E., Kollander, R., Sreerama, L., & Kiang, D. T. (2002). Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemotherapy and Pharmacology, 49, 309–321. https://​doi.​org/​10.​1007/​s00280-001-0412-4CrossRefPubMed
18.
Zurück zum Zitat Furth, J., Kahn, M. C., & Breedis, C. (1937). The transmission of leukemia of mice with a single cell. The American Journal of Cancer, 31, 276–282. Furth, J., Kahn, M. C., & Breedis, C. (1937). The transmission of leukemia of mice with a single cell. The American Journal of Cancer, 31, 276–282.
19.
Zurück zum Zitat Dick, J. E. (2008). Stem cell concepts renew cancer research. Blood, The Journal of the American Society of Hematology, 112, 4793–4807. Dick, J. E. (2008). Stem cell concepts renew cancer research. Blood, The Journal of the American Society of Hematology, 112, 4793–4807.
20.
Zurück zum Zitat Visvader, J. E., & Lindeman, G. J. (2008). Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nature Reviews Cancer, 8, 755–768.CrossRefPubMed Visvader, J. E., & Lindeman, G. J. (2008). Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nature Reviews Cancer, 8, 755–768.CrossRefPubMed
21.
Zurück zum Zitat Iwata, M. (1968). Study of serum lipids in infants. 1. Serum lipids in healthy infants. Nihon Shonika Gakkai Zasshi Acta Paediatrica Japonica, 72, 1075–1081.PubMed Iwata, M. (1968). Study of serum lipids in infants. 1. Serum lipids in healthy infants. Nihon Shonika Gakkai Zasshi Acta Paediatrica Japonica, 72, 1075–1081.PubMed
22.
Zurück zum Zitat Phi, L.T.H., Sari, I.N., Yang, Y.-G., Lee, S.-H., Jun, N., Kim, K.S., Lee, Y.K., Kwon, H.Y. (2018). Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment. Stem Cells International, 2018, 5416923. https://doi.org/10.1155/2018/5416923 Phi, L.T.H., Sari, I.N., Yang, Y.-G., Lee, S.-H., Jun, N., Kim, K.S., Lee, Y.K., Kwon, H.Y. (2018). Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment. Stem Cells International, 2018, 5416923. https://​doi.​org/​10.​1155/​2018/​5416923
23.
Zurück zum Zitat Shervington, A., & Lu, C. (2008). Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Investigation, 26, 535–542.CrossRefPubMed Shervington, A., & Lu, C. (2008). Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Investigation, 26, 535–542.CrossRefPubMed
24.
Zurück zum Zitat Vinogradov, S., & Wei, X. (2012). Cancer stem cells and drug resistance: The potential of nanomedicine. Nanomedicine, 7, 597–615.CrossRefPubMed Vinogradov, S., & Wei, X. (2012). Cancer stem cells and drug resistance: The potential of nanomedicine. Nanomedicine, 7, 597–615.CrossRefPubMed
26.
Zurück zum Zitat Reynolds, I. S., Fichtner, M., McNamara, D. A., Kay, E. W., Prehn, J. H. M., & Burke, J. P. (2019). Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers. Cancer and Metastasis Reviews, 38, 237–257. https://doi.org/10.1007/s10555-019-09781-wCrossRefPubMed Reynolds, I. S., Fichtner, M., McNamara, D. A., Kay, E. W., Prehn, J. H. M., & Burke, J. P. (2019). Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers. Cancer and Metastasis Reviews, 38, 237–257. https://​doi.​org/​10.​1007/​s10555-019-09781-wCrossRefPubMed
33.
35.
Zurück zum Zitat Andrianifahanana, M., Moniaux, N., Schmied, B. M., Ringel, J., Friess, H., Hollingsworth, M. A., Büchler, M. W., Aubert, J. P., & Batra, S. K. (2001). Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumor marker of diagnostic significance. Clinical Cancer Research, 7, 4033–4040.PubMed Andrianifahanana, M., Moniaux, N., Schmied, B. M., Ringel, J., Friess, H., Hollingsworth, M. A., Büchler, M. W., Aubert, J. P., & Batra, S. K. (2001). Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumor marker of diagnostic significance. Clinical Cancer Research, 7, 4033–4040.PubMed
38.
Zurück zum Zitat Giuntoli, R. L., Rodriguez, G. C., Whitaker, R. S., Dodge, R., & Voynow, J. A. (1998). Mucin gene expression in ovarian cancers. Cancer Research, 58, 5546–5550.PubMed Giuntoli, R. L., Rodriguez, G. C., Whitaker, R. S., Dodge, R., & Voynow, J. A. (1998). Mucin gene expression in ovarian cancers. Cancer Research, 58, 5546–5550.PubMed
46.
Zurück zum Zitat Desseyn, J.-L., Gouyer, V., Tetaert, T. (2008). Architecture of the gel-forming mucins. The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, Isabelle Van Seuningen/Research Signpost, 1–16, 978-81-308-0256-5. ⟨hal-02340996⟩. Desseyn, J.-L., Gouyer, V., Tetaert, T. (2008). Architecture of the gel-forming mucins. The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, Isabelle Van Seuningen/Research Signpost, 1–16, 978-81-308-0256-5. ⟨hal-02340996⟩.
50.
Zurück zum Zitat Segui-Perez, C., Stapels, D.A.C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wu, W., Putten, J.P.M.V., Strijbis, K. (2022). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. bioRxiv,. https://doi.org/10.1101/2022.10.27.51398 Segui-Perez, C., Stapels, D.A.C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wu, W., Putten, J.P.M.V., Strijbis, K. (2022). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. bioRxiv,. https://​doi.​org/​10.​1101/​2022.​10.​27.​51398
57.
58.
Zurück zum Zitat Filippou, P. S., Ren, A. H., Korbakis, D., Dimitrakopoulos, L., Soosaipillai, A., Barak, V., Frenkel, S., Pe’er, J., Lotem, M., Merims, S., et al. (2018). Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases. Clinical Chemistry and Laboratory Medicine, 56, 1945–1953. https://doi.org/10.1515/cclm-2018-0139CrossRefPubMed Filippou, P. S., Ren, A. H., Korbakis, D., Dimitrakopoulos, L., Soosaipillai, A., Barak, V., Frenkel, S., Pe’er, J., Lotem, M., Merims, S., et al. (2018). Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases. Clinical Chemistry and Laboratory Medicine, 56, 1945–1953. https://​doi.​org/​10.​1515/​cclm-2018-0139CrossRefPubMed
59.
63.
Zurück zum Zitat Stiles, Z. E., Khan, S., Patton, K. T., Jaggi, M., Behrman, S. W., & Chauhan, S. C. (2019). Transmembrane mucin MUC13 distinguishes intraductal papillary mucinous neoplasms from non-mucinous cysts and is associated with high-risk lesions. HPB: The Official Journal of the International Hepato Pancreato Biliary Association, 21, 87–95. https://doi.org/10.1016/j.hpb.2018.07.009CrossRefPubMed Stiles, Z. E., Khan, S., Patton, K. T., Jaggi, M., Behrman, S. W., & Chauhan, S. C. (2019). Transmembrane mucin MUC13 distinguishes intraductal papillary mucinous neoplasms from non-mucinous cysts and is associated with high-risk lesions. HPB: The Official Journal of the International Hepato Pancreato Biliary Association, 21, 87–95. https://​doi.​org/​10.​1016/​j.​hpb.​2018.​07.​009CrossRefPubMed
71.
Zurück zum Zitat Sheng, Y., Ng, C. P., Lourie, R., Shah, E. T., He, Y., Wong, K. Y., Seim, I., Oancea, I., Morais, C., Jeffery, P. L., et al. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140, 2351–2363. https://doi.org/10.1002/ijc.30651CrossRefPubMed Sheng, Y., Ng, C. P., Lourie, R., Shah, E. T., He, Y., Wong, K. Y., Seim, I., Oancea, I., Morais, C., Jeffery, P. L., et al. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140, 2351–2363. https://​doi.​org/​10.​1002/​ijc.​30651CrossRefPubMed
86.
Zurück zum Zitat Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., et al. (2017). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36, 700–713. https://doi.org/10.1038/onc.2016.241CrossRefPubMed Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., et al. (2017). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36, 700–713. https://​doi.​org/​10.​1038/​onc.​2016.​241CrossRefPubMed
88.
Zurück zum Zitat Doxtater, K., Tripathi, M. K., Sekhri, R., Hafeez, B. B., Khan, S., Zafar, N., Behrman, S. W., Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2023). MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Life Sci Alliance, 6(12). https://doi.org/10.26508/lsa.202301975 Doxtater, K., Tripathi, M. K., Sekhri, R., Hafeez, B. B., Khan, S., Zafar, N., Behrman, S. W., Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2023). MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Life Sci Alliance, 6(12). https://​doi.​org/​10.​26508/​lsa.​202301975
95.
Zurück zum Zitat Ren, A. H., Filippou, P. S., Soosaipillai, A., Dimitrakopoulos, L., Korbakis, D., Leung, F., Kulasingam, V., Bernardini, M. Q., & Diamandis, E. P. (2023). Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: Potential to complement CA125 in detecting non-serous subtypes. Clinical Chemistry and Laboratory Medicine, 61, 464–472. https://doi.org/10.1515/cclm-2022-0491CrossRefPubMed Ren, A. H., Filippou, P. S., Soosaipillai, A., Dimitrakopoulos, L., Korbakis, D., Leung, F., Kulasingam, V., Bernardini, M. Q., & Diamandis, E. P. (2023). Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: Potential to complement CA125 in detecting non-serous subtypes. Clinical Chemistry and Laboratory Medicine, 61, 464–472. https://​doi.​org/​10.​1515/​cclm-2022-0491CrossRefPubMed
100.
Zurück zum Zitat Hammerman, P. S., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Getz, G., Sougnez, C., Imielinski, M., Helman, E., Hernandez, B., Pho, N. H., Meyerson, M., Chu, A., Chun, H.-J. E., et al. Comprehensive genomic characterization of squamous cell lung cancers. PubMed. nih.gov Hammerman, P. S., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Getz, G., Sougnez, C., Imielinski, M., Helman, E., Hernandez, B., Pho, N. H., Meyerson, M., Chu, A., Chun, H.-J. E., et al. Comprehensive genomic characterization of squamous cell lung cancers. PubMed. nih.​gov
102.
Zurück zum Zitat Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Neil Hayes, D., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R., … John Flynn, H. (2014). Comprehensive molecular profiling of lung adenocarcinoma. Nature, 511(7511), 543–550. https://doi.org/10.1038/nature13385ADSCrossRef Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Neil Hayes, D., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R., … John Flynn, H. (2014). Comprehensive molecular profiling of lung adenocarcinoma. Nature, 511(7511), 543–550. https://​doi.​org/​10.​1038/​nature13385ADSCrossRef
107.
117.
121.
Zurück zum Zitat Ramos, E. K., Hoffmann, A. D., Gerson, S. L., & Liu, H. (2017). New opportunities and challenges to defeat cancer stem cells. Trends in cancer, 3, 780–796.CrossRefPubMedPubMedCentral Ramos, E. K., Hoffmann, A. D., Gerson, S. L., & Liu, H. (2017). New opportunities and challenges to defeat cancer stem cells. Trends in cancer, 3, 780–796.CrossRefPubMedPubMedCentral
122.
Zurück zum Zitat Singh, A., & Settleman, J. (2010). EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene, 29, 4741–4751.CrossRefPubMedPubMedCentral Singh, A., & Settleman, J. (2010). EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene, 29, 4741–4751.CrossRefPubMedPubMedCentral
123.
Zurück zum Zitat Flanagan, D. J., Barker, N., Costanzo, N. S. D., Mason, E. A., Gurney, A., Meniel, V. S., Koushyar, S., Austin, C. R., Ernst, M., & Pearson, H. B. (2019). Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations. Cancer Research, 79, 970–981.CrossRefPubMed Flanagan, D. J., Barker, N., Costanzo, N. S. D., Mason, E. A., Gurney, A., Meniel, V. S., Koushyar, S., Austin, C. R., Ernst, M., & Pearson, H. B. (2019). Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations. Cancer Research, 79, 970–981.CrossRefPubMed
124.
Zurück zum Zitat Zhang, Y., Morris, J. P., IV., Yan, W., Schofield, H. K., Gurney, A., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & Pasca di Magliano, M. (2013). Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Research, 73, 4909–4922.CrossRefPubMedPubMedCentral Zhang, Y., Morris, J. P., IV., Yan, W., Schofield, H. K., Gurney, A., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & Pasca di Magliano, M. (2013). Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Research, 73, 4909–4922.CrossRefPubMedPubMedCentral
125.
Zurück zum Zitat Sinnberg, T., Levesque, M. P., Krochmann, J., Cheng, P. F., Ikenberg, K., Meraz-Torres, F., Niessner, H., Garbe, C., & Busch, C. (2018). Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Molecular Cancer, 17, 1–19.CrossRef Sinnberg, T., Levesque, M. P., Krochmann, J., Cheng, P. F., Ikenberg, K., Meraz-Torres, F., Niessner, H., Garbe, C., & Busch, C. (2018). Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Molecular Cancer, 17, 1–19.CrossRef
126.
Zurück zum Zitat Liu, Y., Chang, Y., Lu, S., & Xiang, Y. Y. (2019). Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway. Journal of Cellular Physiology, 234, 11662–11669.CrossRefPubMed Liu, Y., Chang, Y., Lu, S., & Xiang, Y. Y. (2019). Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway. Journal of Cellular Physiology, 234, 11662–11669.CrossRefPubMed
127.
Zurück zum Zitat Veeck, J., Bektas, N., Hartmann, A., Kristiansen, G., Heindrichs, U., Knüchel, R., & Dahl, E. (2008). Wnt signalling in human breast cancer: Expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. Breast Cancer Research, 10, 1–11.CrossRef Veeck, J., Bektas, N., Hartmann, A., Kristiansen, G., Heindrichs, U., Knüchel, R., & Dahl, E. (2008). Wnt signalling in human breast cancer: Expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. Breast Cancer Research, 10, 1–11.CrossRef
128.
Zurück zum Zitat Murillo-Garzón, V., & Kypta, R. (2017). WNT signalling in prostate cancer. Nature Reviews Urology, 14, 683–696.CrossRefPubMed Murillo-Garzón, V., & Kypta, R. (2017). WNT signalling in prostate cancer. Nature Reviews Urology, 14, 683–696.CrossRefPubMed
129.
Zurück zum Zitat McCord, M., Mukouyama, Y.-S., Gilbert, M. R., & Jackson, S. (2017). Targeting WNT signaling for multifaceted glioblastoma therapy. Frontiers in cellular neuroscience, 11, 318.CrossRefPubMedPubMedCentral McCord, M., Mukouyama, Y.-S., Gilbert, M. R., & Jackson, S. (2017). Targeting WNT signaling for multifaceted glioblastoma therapy. Frontiers in cellular neuroscience, 11, 318.CrossRefPubMedPubMedCentral
130.
Zurück zum Zitat van Andel, H., Kocemba, K. A., Spaargaren, M., & Pals, S. T. (2019). Aberrant Wnt signaling in multiple myeloma: Molecular mechanisms and targeting options. Leukemia, 33, 1063–1075.CrossRefPubMedPubMedCentral van Andel, H., Kocemba, K. A., Spaargaren, M., & Pals, S. T. (2019). Aberrant Wnt signaling in multiple myeloma: Molecular mechanisms and targeting options. Leukemia, 33, 1063–1075.CrossRefPubMedPubMedCentral
131.
Zurück zum Zitat Ashihara, E., Takada, T., & Maekawa, T. (2015). Targeting the canonical Wnt/β-catenin pathway in hematological malignancies. Cancer Science, 106, 665–671.CrossRefPubMedPubMedCentral Ashihara, E., Takada, T., & Maekawa, T. (2015). Targeting the canonical Wnt/β-catenin pathway in hematological malignancies. Cancer Science, 106, 665–671.CrossRefPubMedPubMedCentral
132.
Zurück zum Zitat Yadav, A. K., & Desai, N. S. (2019). Cancer stem cells: Acquisition, characteristics, therapeutic implications, targeting strategies and future prospects. Stem Cell Reviews and Reports, 15, 331–355.CrossRefPubMed Yadav, A. K., & Desai, N. S. (2019). Cancer stem cells: Acquisition, characteristics, therapeutic implications, targeting strategies and future prospects. Stem Cell Reviews and Reports, 15, 331–355.CrossRefPubMed
134.
Zurück zum Zitat Jaiswal, R., Luk, F., Dalla, P. V., Grau, G. E. R., & Bebawy, M. (2013). Breast cancer-derived microparticles display tissue selectivity in the transfer of resistance proteins to cells. PLoS ONE, 8, e61515.ADSCrossRefPubMedPubMedCentral Jaiswal, R., Luk, F., Dalla, P. V., Grau, G. E. R., & Bebawy, M. (2013). Breast cancer-derived microparticles display tissue selectivity in the transfer of resistance proteins to cells. PLoS ONE, 8, e61515.ADSCrossRefPubMedPubMedCentral
135.
Zurück zum Zitat Vesel, M., Rapp, J., Feller, D., Kiss, E., Jaromi, L., Meggyes, M., Miskei, G., Duga, B., Smuk, G., & Laszlo, T. (2017). ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling. Respiratory Research, 18, 1–11.CrossRef Vesel, M., Rapp, J., Feller, D., Kiss, E., Jaromi, L., Meggyes, M., Miskei, G., Duga, B., Smuk, G., & Laszlo, T. (2017). ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling. Respiratory Research, 18, 1–11.CrossRef
136.
Zurück zum Zitat Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P., et al. (1994). Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell, 77, 491–502. https://doi.org/10.1016/0092-8674(94)90212-7CrossRefPubMed Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P., et al. (1994). Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell, 77, 491–502. https://​doi.​org/​10.​1016/​0092-8674(94)90212-7CrossRefPubMed
138.
Zurück zum Zitat Cerezo, D., Lencina, M., Ruiz-Alcaraz, A. J., Ferragut, J. A., Saceda, M., Sanchez, M., Cánovas, M., García-Peñarrubia, P., & Martín-Orozco, E. (2012). Acquisition of MDR phenotype by leukemic cells is associated with increased caspase-3 activity and a collateral sensitivity to cold stress. Journal of Cellular Biochemistry, 113, 1416–1425. https://doi.org/10.1002/jcb.24016CrossRefPubMed Cerezo, D., Lencina, M., Ruiz-Alcaraz, A. J., Ferragut, J. A., Saceda, M., Sanchez, M., Cánovas, M., García-Peñarrubia, P., & Martín-Orozco, E. (2012). Acquisition of MDR phenotype by leukemic cells is associated with increased caspase-3 activity and a collateral sensitivity to cold stress. Journal of Cellular Biochemistry, 113, 1416–1425. https://​doi.​org/​10.​1002/​jcb.​24016CrossRefPubMed
140.
Zurück zum Zitat Pallis, M., & Russell, N. (2000). P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway. Blood, 95, 2897–2904.CrossRefPubMed Pallis, M., & Russell, N. (2000). P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway. Blood, 95, 2897–2904.CrossRefPubMed
146.
Zurück zum Zitat Leibovitz, A., Stinson, J. C., McCombs, W. B., 3rd., McCoy, C. E., Mazur, K. C., & Mabry Mabry, N. D. (1976). Classification of human colorectal adenocarcinoma cell lines. Cancer Research, 36, 4562–4569.PubMed Leibovitz, A., Stinson, J. C., McCombs, W. B., 3rd., McCoy, C. E., Mazur, K. C., & Mabry Mabry, N. D. (1976). Classification of human colorectal adenocarcinoma cell lines. Cancer Research, 36, 4562–4569.PubMed
147.
Zurück zum Zitat Xu, Z., Liu, Y., Yang, Y., Wang, J., Zhang, G., Liu1, Z., Fu, H., Wang, Z., Liu, H., & Xu, J. (2016). High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget, 8(5), 7548–7558. Xu, Z., Liu, Y., Yang, Y., Wang, J., Zhang, G., Liu1, Z., Fu, H., Wang, Z., Liu, H., & Xu, J. (2016). High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget, 8(5), 7548–7558.
148.
Zurück zum Zitat Khan, S., Ebeling, M. C., Zaman, M. S., Sikander, M., Yallapu, M. M., Chauhan, N., Yacoubian, A. M., Behrman, S. W., Zafar, N., Kumar, D., et al. (2014). MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer. Oncotarget, 5(17), 7599–7609.CrossRefPubMedPubMedCentral Khan, S., Ebeling, M. C., Zaman, M. S., Sikander, M., Yallapu, M. M., Chauhan, N., Yacoubian, A. M., Behrman, S. W., Zafar, N., Kumar, D., et al. (2014). MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer. Oncotarget, 5(17), 7599–7609.CrossRefPubMedPubMedCentral
149.
152.
Zurück zum Zitat Sikander, M., Malik, S., Khan, S., Kumari, S., Chauhan, N., Khan, P., Halaweish, F.T., Chauhan, B., Yallapu, M. M., Jaggi, M., et al. (2019). Novel mechanistic insight into the anticancer activity of cucurbitacin D against pancreatic cancer (Cuc D attenuates pancreatic cancer). Cells, 9. https://doi.org/10.3390/cells9010103. Sikander, M., Malik, S., Khan, S., Kumari, S., Chauhan, N., Khan, P., Halaweish, F.T., Chauhan, B., Yallapu, M. M., Jaggi, M., et al. (2019). Novel mechanistic insight into the anticancer activity of cucurbitacin D against pancreatic cancer (Cuc D attenuates pancreatic cancer). Cells, 9. https://​doi.​org/​10.​3390/​cells9010103.
155.
Zurück zum Zitat Gurdon, J. B. (1962). The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. Journal of Embryology and Experimental Morphology, 10, 622–640.PubMed Gurdon, J. B. (1962). The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. Journal of Embryology and Experimental Morphology, 10, 622–640.PubMed
160.
Zurück zum Zitat Iwata, M. (1968). Study of serum lipids in infants. 1. Serum lipids in healthy infants].Nihon Shonika Gakkai Zasshi, 72, 1075–1081.PubMed Iwata, M. (1968). Study of serum lipids in infants. 1. Serum lipids in healthy infants].Nihon Shonika Gakkai Zasshi, 72, 1075–1081.PubMed
175.
Zurück zum Zitat Sherbet, G. V., & Lakshmi, M. S. (1998). S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Research, 18, 2415–2421.PubMed Sherbet, G. V., & Lakshmi, M. S. (1998). S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Research, 18, 2415–2421.PubMed
178.
Zurück zum Zitat Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfør, K., Rofstad, E. K., & Mueller-Klieser, W. (2000). High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Research, 60, 916–921.PubMed Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfør, K., Rofstad, E. K., & Mueller-Klieser, W. (2000). High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Research, 60, 916–921.PubMed
183.
Zurück zum Zitat Ajduković, J. (2016). HIF-1–a big chapter in the cancer tale. Experimental Oncology, 38, 9–12.CrossRefPubMed Ajduković, J. (2016). HIF-1–a big chapter in the cancer tale. Experimental Oncology, 38, 9–12.CrossRefPubMed
189.
192.
Zurück zum Zitat Hashimoto, O., Shimizu, K., Semba, S., Chiba, S., Ku, Y., Yokozaki, H., & Hori, Y. (2011). Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells. Pathobiology, 78, 181–192. https://doi.org/10.1159/000325538CrossRefPubMed Hashimoto, O., Shimizu, K., Semba, S., Chiba, S., Ku, Y., Yokozaki, H., & Hori, Y. (2011). Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells. Pathobiology, 78, 181–192. https://​doi.​org/​10.​1159/​000325538CrossRefPubMed
194.
198.
201.
Zurück zum Zitat Chang, L., Graham, P. H., Hao, J., Ni, J., Bucci, J., Cozzi, P. J., Kearsley, J. H., & Li, Y. (2013). Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death & Disease, 4, e875. https://doi.org/10.1038/cddis.2013.407CrossRef Chang, L., Graham, P. H., Hao, J., Ni, J., Bucci, J., Cozzi, P. J., Kearsley, J. H., & Li, Y. (2013). Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death & Disease, 4, e875. https://​doi.​org/​10.​1038/​cddis.​2013.​407CrossRef
202.
Zurück zum Zitat Zhou, J., Wulfkuhle, J., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, E., 3rd., & Zhang, Y. (2007). Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proceedings of the National Academy of Sciences of the United States of America, 104, 16158–16163. https://doi.org/10.1073/pnas.0702596104ADSCrossRefPubMedPubMedCentral Zhou, J., Wulfkuhle, J., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, E., 3rd., & Zhang, Y. (2007). Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proceedings of the National Academy of Sciences of the United States of America, 104, 16158–16163. https://​doi.​org/​10.​1073/​pnas.​0702596104ADSCrossRefPubMedPubMedCentral
206.
Zurück zum Zitat Sunayama, J., Matsuda, K., Sato, A., Tachibana, K., Suzuki, K., Narita, Y., Shibui, S., Sakurada, K., Kayama, T., Tomiyama, A., et al. (2010). Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells, 28, 1930–1939. https://doi.org/10.1002/stem.521CrossRefPubMed Sunayama, J., Matsuda, K., Sato, A., Tachibana, K., Suzuki, K., Narita, Y., Shibui, S., Sakurada, K., Kayama, T., Tomiyama, A., et al. (2010). Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells, 28, 1930–1939. https://​doi.​org/​10.​1002/​stem.​521CrossRefPubMed
Metadaten
Titel
Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
verfasst von
Shabnam Malik
Mohammed Sikander
Mohd Wahid
Anupam Dhasmana
Maryam Sarwat
Sheema Khan
Everardo Cobos
Murali M. Yallapu
Meena Jaggi
Subhash C. Chauhan
Publikationsdatum
18.03.2024
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-024-10177-8

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

16.05.2024 alpha-1-Rezeptorantagonisten Nachrichten

Nach einer Prostatabiopsie treten häufig Probleme beim Wasserlassen auf. Ob sich das durch den periinterventionellen Einsatz von Alphablockern verhindern lässt, haben australische Mediziner im Zuge einer Metaanalyse untersucht.

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

16.05.2024 Zielgerichtete Therapie Nachrichten

Trastuzumab deruxtecan scheint auch jenseits von Lungenkrebs gut gegen solide Tumoren mit HER2-Mutationen zu wirken. Dafür sprechen die Daten einer offenen Pan-Tumor-Studie.

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

15.05.2024 Mammakarzinom Nachrichten

Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

13.05.2024 Pankreaskarzinom Nachrichten

Gerade bei aggressiven Malignomen wie dem duktalen Adenokarzinom des Pankreas könnte Früherkennung die Therapiechancen verbessern. Noch jedoch klafft hier eine Lücke. Ein Studienteam hat einen Weg gesucht, sie zu schließen.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.