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Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

04.03.2023 | Original Article

Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers

verfasst von: Prakash Pandit, Roshankumar Patil, Vijay Palwe, Sucheta Gandhe, Dhruti Manek, Rahul Patil, Sirshendu Roy, Venkata Ramesh Yasam, Viren Raj Nagarkar, Raj Nagarkar

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 3/2023

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Abstract

Aims

The present study examines the role of demographic and pathological features of primary tumours in predicting neck metastasis in early oral cavity cancers, which has been a matter of debate.

Methods

A single-centre, retrospective, institution review was conducted of all the patients presented to our centre from January 2014 to December 2021. Patient characteristics were compared between the two lymph node groups (lymph node positive and lymph node negative) and significant prognostic factors were determined.

Results

A total of 462 oral squamous cell carcinoma (OSCC) patients were included, 407 male and 55 female. Tobacco chewing (59.2%) was a major habit with buccal mucosa (49.5%) and tongue (44.8%) as primary sites. The majority of the patient’s histology was of SCC (96.8%) with grade II (moderately differentiated, 74.5%). Univariate logistic regression analysis to predict lymph node metastasis showed pT size (< 0.001), LVI (< 0.001), and PNI (< 0.001) as significant tumor characteristics. On multivariate, pT size (OR-1.58, P – 0.0001) and LVI (OR-19.70, P – 0.0001) were reported to be statistically significant to predict lymph node metastasis.

Conclusion

Reporting and studying the clinico-pathological features of primary tumors can give vital information in predicting the neck node metastasis in OSCC patients.

Ren ZH, Hu CY, He HR et al (2020) Global and regional burdens of oral cancer from 1990 to 2017: results from the global burden of disease study. Cancer Commun 40:81–92. https://doi.org/10.1002/CAC2.12009CrossRef

Kuan EC, Clair JMS, Badran KW, St. John MA (2016) How does depth of invasion influence the decision to do a neck dissection in clinically N0 oral cavity cancer? Laryngoscope 126:547–548. https://doi.org/10.1002/LARY.25707/FULLCrossRefPubMed

Zanoni DK, Patel SG, Shah JP (2019) Changes in the 8th Edition of the american Joint Committee on Cancer (AJCC) staging of Head and Neck Cancer: Rationale and Implications. Curr Oncol Rep 21:52. https://doi.org/10.1007/S11912-019-0799-XCrossRefPubMedPubMedCentral

Quintin A, Pontejos Y, Del Mundo DAA (2020) The role of Neck dissection in oral cavity carcinoma. Oral Dis. https://doi.org/10.5772/INTECHOPEN.90925CrossRef

Faisal M, Bakar MA, Sarwar A et al (2018) Depth of invasion (DOI) as a predictor of cervical nodal metastasis and local recurrence in early stage squamous cell carcinoma of oral tongue (ESSCOT). Plos One 13(8), 0202632.CrossRef

Aaboubout Y, van der Toom QM, de Ridder MAJ et al (2021) Is the depth of Invasion a marker for Elective Neck dissection in early oral squamous cell carcinoma? Front Oncol 11:434. https://doi.org/10.3389/FONC.2021.628320/BIBTEXCrossRef

van Lanschot CGF, Klazen YP, de Ridder MAJ et al (2020) Depth of invasion in early stage oral cavity squamous cell carcinoma: the optimal cut-off value for elective neck dissection. Oral Oncol 111:104940–104940. https://doi.org/10.1016/J.ORALONCOLOGY.2020.104940CrossRefPubMed

Eryılmaz MK, Korkmaz M, Karaağaç M, Artaç M (2022) Perineural invasion is a better prognostic factor than extranodal extension in head and neck cancer. Egypt J Otolaryngol 381(38):1–8.

Subramaniam N, Balasubramanian D, Murthy S et al (2019) Predictors of locoregional control in stage I/II oral squamous cell carcinoma classified by AJCC 8th edition. Eur J Surg Oncol 45:2126–2130. https://doi.org/10.1016/J.EJSO.2019.05.018CrossRefPubMed

10.

Ting KC, Lee TL, Li WY et al (2021) Perineural invasion/lymphovascular invasion double positive predicts distant metastasis and poor survival in T3-4 oral squamous cell carcinoma. Sci Rep https://doi.org/10.1038/S41598-021-99280-2CrossRefPubMedPubMedCentral

11.

Jones HB, Sykes A, Bayman N et al (2009) The impact of lymphovascular invasion on survival in oral carcinoma. Oral Oncol 45:10–15. https://doi.org/10.1016/J.ORALONCOLOGY.2008.03.009CrossRefPubMed

12.

Chatzistefanou I, Lubek J, Markou K, Ord RA (2017) The role of perineural invasion in treatment decisions for oral cancer patients: a review of the literature. J Craniomaxillofac Surg 45:821–825. https://doi.org/10.1016/J.JCMS.2017.02.022CrossRefPubMed

13.

Metastasis from oral cancer: an overview - PubMed. https://pubmed.ncbi.nlm.nih.gov/22990112/. Accessed 24 May 2022

14.

Choi KY, Park SC, Kim JH, Lee DJ (2021) The occult nodal metastasis rate of early tongue cancer (T1–T2): a protocol for a systematic review and meta-analysis. Med (Baltim) https://doi.org/10.1097/MD.0000000000024327CrossRefPubMedPubMedCentral

15.

Prognostic significance of the distribution of neck node metastasis from oral carcinoma - PubMed. https://pubmed.ncbi.nlm.nih.gov/10748442/. Accessed 24 May 2022

16.

Gil Z, Carlson DL, Boyle JO et al (2009) Lymph node density is a significant predictor of outcome in patients with oral cancer. Cancer 115:5700–5710. https://doi.org/10.1002/CNCR.24631CrossRefPubMed

17.

Cho JK, Hyun SH, Choi N et al (2015) Significance of Lymph Node Metastasis in Cancer Dissemination of Head and Neck Cancer. Transl Oncol 8:119. https://doi.org/10.1016/J.TRANON.2015.03.001CrossRefPubMedPubMedCentral

18.

Spoerl S, Gerken M, Mamilos A et al (2021) Lymph node ratio as a predictor for outcome in oral squamous cell carcinoma: a multicenter population-based cohort study. Clin Oral Investig 25:1705–1713. https://doi.org/10.1007/S00784-020-03471-6CrossRefPubMed

19.

Abdulla R, Adyanthaya S, Kini P et al (2018) Clinicopathological analysis of oral squamous cell carcinoma among the younger age group in coastal Karnataka, India: a retrospective study. J Oral Maxillofac Pathol 22:180. https://doi.org/10.4103/JOMFP.JOMFP_16_18CrossRefPubMedPubMedCentral

20.

Müller S, Pan Y, Li R, Chi AC (2008) Changing Trends in oral squamous cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University experience. Head Neck Pathol 2:60. https://doi.org/10.1007/S12105-008-0054-5CrossRefPubMedPubMedCentral

21.

D’Cruz AK, Vaish R, Kapre N et al (2015) Elective versus therapeutic Neck dissection in node-negative oral Cancer. N Engl J Med 373:521–529. https://doi.org/10.1056/NEJMOA1506007/SUPPL_FILE/NEJMOA1506007_DISCLOSURES.PDFCrossRefPubMed

22.

D’Cruz AK, Dhar H, Vaish R et al (2021) Depth of invasion in early oral cancers- is it an independent prognostic factor? Eur J Surg Oncol 47:1940–1946. https://doi.org/10.1016/J.EJSO.2021.03.243CrossRefPubMed

23.

Ahluwalia KP (2005) Assessing the oral Cancer risk of South-Asian Immigrants in New York City. Cancer 104:2959. https://doi.org/10.1002/CNCR.21502CrossRefPubMed

24.

Sahoo A, Panda S, Mohanty N et al (2020) Perinerural, lymphovascular and depths of invasion in extrapolating nodal metastasis in oral cancer. Clin Oral Investig 24:747–755. https://doi.org/10.1007/S00784-019-02921-0CrossRefPubMed

25.

Zhan KY, Morgan PF, Neskey DM et al (2018) Preoperative predictors of occult nodal disease in cT1N0 oral cavity squamous cell carcinoma: review of 2623 cases. Head Neck 40:1967–1976. https://doi.org/10.1002/HED.25178CrossRefPubMed

26.

Almangush A, Bello IO, Coletta RD et al (2015) For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality. Virchows Arch 2015 4671 467:39–46. https://doi.org/10.1007/S00428-015-1758-ZCrossRef

27.

Kozak MM, Shah J, Chen M et al (2019) Depth of invasion alone as a prognostic factor in low-risk early-stage oral cavity carcinoma. Laryngoscope 129:2082–2086. https://doi.org/10.1002/LARY.27753CrossRefPubMed

28.

Tam S, Amit M, Zafereo M et al (2019) Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma. Head Neck 41:177–184. https://doi.org/10.1002/HED.25506CrossRefPubMed

29.

Brockhoff HC, Kim RY, Braun TM et al (2017) Correlating the depth of invasion at specific anatomic locations with the risk for regional metastatic disease to lymph nodes in the neck for oral squamous cell carcinoma. Head Neck 39:974–979. CrossRefPubMed

30.

Huang S, Zhu Y, Cai H et al (2021) Impact of lymphovascular invasion in oral squamous cell carcinoma: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 131:319–328e1. https://doi.org/10.1016/J.OOOO.2020.10.026CrossRefPubMed

31.

Mascitti M, Togni L, Caponio VCA et al (2022) Lymphovascular invasion as a prognostic tool for oral squamous cell carcinoma: a comprehensive review. Int J Oral Maxillofac Surg 51:1–9. https://doi.org/10.1016/J.IJOM.2021.03.007CrossRefPubMed

32.

Fowler BZ, Crocker IR, Johnstone PAS (2005) Perineural spread of cutaneous malignancy to the brain: a review of the literature and five patients treated with stereotactic radiotherapy. Cancer 103:2143–2153. https://doi.org/10.1002/CNCR.21004CrossRefPubMed

33.

Deepthi G, Shyam N, Kumar G et al (2020) Characterization of perineural invasion in different histological grades and variants of oral squamous cell carcinoma. J Oral Maxillofac Pathol 24:57. https://doi.org/10.4103/JOMFP.JOMFP_162_19CrossRefPubMedPubMedCentral

34.

Larson AR, Kemmer J, Formeister E et al (2020) Beyond depth of Invasion: adverse pathologic tumor features in early oral tongue squamous cell carcinoma. Laryngoscope 130:1715–1720. https://doi.org/10.1002/LARY.28241CrossRefPubMed

35.

Govers TM, Hannink G, Merkx MAW 2013 Sentinel node biopsy for squamous cell carcinoma of the oral cavity and oropharynx: A diagnostic meta-analysis. Oral Oncol 49:726–732.CrossRefPubMed

36.

Barroso EM, Smits RW, Bakker STC et al (2013) Discrimination between oral cancer and healthy tissue based on water content determined by Raman spectroscopy. Anal Chem. 87(4):2419-26CrossRef

37.

Santos IP, Barroso EM, Bakker STC et al (2017) Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics. Analyst 142(17):3025–3047. https://doi.org/10.1039/c7an00957gCrossRefPubMed

Titel: Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers
verfasst von: Prakash Pandit
Roshankumar Patil
Vijay Palwe
Sucheta Gandhe
Dhruti Manek
Rahul Patil
Sirshendu Roy
Venkata Ramesh Yasam
Viren Raj Nagarkar
Raj Nagarkar
Publikationsdatum: 04.03.2023
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 3/2023
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-023-03637-0

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Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers

Abstract