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23.06.2022 | Research Article

Effect of pulmonary vein isolation on the relationship between left atrial reverse remodeling and sympathetic nerve activity in patients with atrial fibrillation

verfasst von: Yusuke Mukai, Hisayoshi Murai, Takuto Hamaoka, Hiroyuki Sugimoto, Oto Inoue, Chiaki Goten, Takashi Kusayama, Shin-ichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Shigeo Takata, Masayuki Takamura

Erschienen in: Clinical Autonomic Research | Ausgabe 4/2022

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Abstract

Purpose

Catheter ablation (CA) to isolate the pulmonary vein, which is an established treatment for atrial fibrillation (AF), is associated with left atrium reverse remodeling (LARR). The intrinsic cardiac autonomic nervous system includes the ganglion plexi adjacent to the pulmonary vein in the left atrium (LA). However, little is known about the effect of CA on the relationship between LARR and sympathetic nerve activity in patients with AF.

Methods

This study enrolled 22 AF patients with a normal left ventricular ejection fraction (LVEF) aged 64.6 ± 12.9 years who were scheduled for CA. Sympathetic nerve activity was evaluated by direct recording of muscle sympathetic nerve activity (MSNA) before and 12 weeks after CA. Blood pressure, heart rate (HR), HR variability, and echocardiography were also measured.

Results

The heart rate increased significantly after CA (63 ± 10.9 vs. 70.6 ± 7.7 beats/min, p < 0.01), but blood pressure did not change. A high frequency (HF) and low frequency (LF) of HR variability decreased significantly after ablation, but no significant change in LF/HF was observed. CA significantly decreased MSNA (38.9 ± 9.9 vs. 28 ± 9.1 bursts/min, p < 0.01). Moreover, regression analysis revealed a positive correlation between the percentage change in MSNA and the LA volume index (r = 0.442, p < 0.05).

Conclusions

Our results show that CA for AF reduced MSNA and the decrease was associated with the LA volume index in AF patients with a normal LVEF. These findings suggest that LARR induced by CA for AF decrease sympathetic nerve activity.

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Titel: Effect of pulmonary vein isolation on the relationship between left atrial reverse remodeling and sympathetic nerve activity in patients with atrial fibrillation
verfasst von: Yusuke Mukai
Hisayoshi Murai
Takuto Hamaoka
Hiroyuki Sugimoto
Oto Inoue
Chiaki Goten
Takashi Kusayama
Shin-ichiro Takashima
Takeshi Kato
Soichiro Usui
Kenji Sakata
Shigeo Takata
Masayuki Takamura
Publikationsdatum: 23.06.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Autonomic Research / Ausgabe 4/2022
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-022-00873-2

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Effect of pulmonary vein isolation on the relationship between left atrial reverse remodeling and sympathetic nerve activity in patients with atrial fibrillation

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

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Results

Conclusions

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