nach oben

Journal of Bone and Mineral Metabolism

Erschienen in:

11.11.2022 | Review Article

Fecal microbiota transplantation as a promising treatment option for osteoporosis

verfasst von: Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Ruo-Lan Zhang, Meng-Ting Wu, Qian Yu, Yun-Feng Rui

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 6/2022

Einloggen, um Zugang zu erhalten

Abstract

Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel “organ transplantation” technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut–bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.

Reid IR (2020) A broader strategy for osteoporosis interventions. Nat Rev Endocrinol 16:333–339. https://doi.org/10.1038/s41574-020-0339-7CrossRefPubMed

Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P (2018) Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet 391:230–240. https://doi.org/10.1016/s0140-6736(17)32137-2CrossRefPubMed

Zhuang HF, Wang PW, Li YZ, Lin JK, Yao XD, Xu H (2020) Analysis of related factors of brittle hip fracture in postmenopausal women with osteoporosis. Orthop Surg 12:194–198. https://doi.org/10.1111/os.12605CrossRefPubMedPubMedCentral

Chawla A, Kwek EBK (2019) Fractures in patients with osteopetrosis, insights from a single institution. Int Orthop 43:1297–1302. https://doi.org/10.1007/s00264-018-4167-5CrossRefPubMed

Zhang YW, Lu PP, Li YJ, Dai GC, Chen MH, Zhao YK, Cao MM, Rui YF (2021) Prevalence, characteristics, and associated risk factors of the elderly with hip fractures: a cross-sectional analysis of NHANES 2005–2010. Clin Interv Aging 16:177–185. https://doi.org/10.2147/cia.S291071CrossRefPubMedPubMedCentral

Zhang YW, Lu PP, Li YJ, Dai GC, Cao MM, Xie T, Zhang C, Shi L, Rui YF (2021) Low dietary choline intake is associated with the risk of osteoporosis in elderly individuals: a population-based study. Food Funct 12:6442–6451. https://doi.org/10.1039/d1fo00825kCrossRefPubMed

Zhang YW, Lu PP, Li YJ, Wang H, Zhao YK, Chen H, Rui YF (2022) Short report: relationship between self-reported sleep characteristics and falls-associated fractures in elderly individuals: a population-based study. Psychol Health Med. https://doi.org/10.1080/13548506.2022.2119482CrossRefPubMed

Kanis JA, Harvey NC, McCloskey E, Bruyère O, Veronese N et al (2020) Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporos Int 31:1–12. https://doi.org/10.1007/s00198-019-05176-3CrossRefPubMed

Zhang YW, Cao MM, Li YJ, Dai GC, Lu PP, Zhang M, Bai LY, Chen XX, Shi L, Zhang C, Rui Y-F (2022) Dietary protein intake in relation to the risk of osteoporosis in middle-aged and older individuals: a cross-sectional study. J Nutr Health Aging 26:252–258. https://doi.org/10.1007/s12603-022-1748-1CrossRefPubMed

10.

Söreskog E, Lindberg I, Kanis JA, Åkesson KE, Willems D, Lorentzon M, Ström O, Berling P, Borgström F (2021) Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden. Osteoporos Int 32:585–594. https://doi.org/10.1007/s00198-020-05780-8CrossRefPubMedPubMedCentral

11.

Estell EG, Rosen CJ (2021) Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis. Nat Rev Endocrinol 17:31–46. https://doi.org/10.1038/s41574-020-00426-5CrossRefPubMed

12.

Wysowski DK, Chang JT (2005) Alendronate and risedronate: reports of severe bone, joint, and muscle pain. Arch Intern Med 165:346–347. https://doi.org/10.1001/archinte.165.3.346-bCrossRefPubMed

13.

Lenart BA, Neviaser AS, Lyman S, Chang CC, Edobor-Osula F, Steele B, van der Meulen MC, Lorich DG, Lane JM (2009) Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study. Osteoporos Int 20:1353–1362. https://doi.org/10.1007/s00198-008-0805-xCrossRefPubMed

14.

Barrett-Connor E, Mosca L, Collins P, Geiger MJ, Grady D, Kornitzer M, McNabb MA, Wenger NK (2006) Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med 355:125–137. https://doi.org/10.1056/NEJMoa062462CrossRefPubMed

15.

Watts NB, Bilezikian JP, Camacho PM, Greenspan SL, Harris ST, Hodgson SF, Kleerekoper M, Luckey MM, McClung MR, Pollack RP, Petak SM (2010) American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract 16:1–37. https://doi.org/10.4158/ep.16.s3.1CrossRefPubMedPubMedCentral

16.

Liu JH, Chen CY, Liu ZZ, Luo ZW, Rao SS et al (2021) Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength. Adv Sci 8:2004831. https://doi.org/10.1002/advs.202004831CrossRef

17.

Biver E, Berenbaum F, Valdes AM, Araujo de Carvalho I, Bindels LB et al (2019) Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO). Ageing Res Rev 55:100946. https://doi.org/10.1016/j.arr.2019.100946CrossRefPubMed

18.

Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ et al (2019) Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol 4:293–305. https://doi.org/10.1038/s41564-018-0306-4CrossRefPubMed

19.

Liu Z, Dai X, Zhang H, Shi R, Hui Y et al (2020) Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nat Commun 11:855. https://doi.org/10.1038/s41467-020-14676-4CrossRefPubMedPubMedCentral

20.

Lee J, d’Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino J, Putluri N, Zhu L, Durgan DJ, Bryan RM Jr, McCullough LD, Venna VR (2020) Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice. Circ Res 127:453–465. https://doi.org/10.1161/circresaha.119.316448CrossRefPubMedPubMedCentral

21.

Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y (2020) Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. Theranostics 10:11302–11323. https://doi.org/10.7150/thno.47746CrossRefPubMedPubMedCentral

22.

Chevalier C, Kieser S, Çolakoğlu M, Hadadi N, Brun J, Rigo D, Suárez-Zamorano N, Spiljar M, Fabbiano S, Busse B, Ivanišević J, Macpherson A, Bonnet N, Trajkovski M (2020) Warmth prevents bone loss through the gut microbiota. Cell Metab 32:575-590.e577. https://doi.org/10.1016/j.cmet.2020.08.012CrossRefPubMedPubMedCentral

23.

Zhang YW, Li YJ, Lu PP, Dai GC, Chen XX, Rui YF (2021) The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of “brain-gut-bone” axis. Food Funct 12:5703–5718. https://doi.org/10.1039/d0fo03468aCrossRefPubMed

24.

Zhang YW, Cao MM, Li YJ, Dai GC, Lu PP, Zhang M, Bai LY, Chen XX, Zhang C, Shi L, Rui YF (2022) The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis. Crit Rev Food Sci Nutr. https://doi.org/10.1080/10408398.2022.2047005CrossRefPubMed

25.

Becattini S, Taur Y, Pamer EG (2016) Antibiotic-induced changes in the intestinal microbiota and disease. Trends Mol Med 22:458–478. https://doi.org/10.1016/j.molmed.2016.04.003CrossRefPubMedPubMedCentral

26.

Weingarden AR, Vaughn BP (2017) Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease. Gut microbes 8:238–252. https://doi.org/10.1080/19490976.2017.1290757CrossRefPubMedPubMedCentral

27.

Gomez-Arango LF, Barrett HL, Wilkinson SA, Callaway LK, McIntyre HD, Morrison M, Dekker Nitert M (2018) Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women. Gut microbes 9:189–201. https://doi.org/10.1080/19490976.2017.1406584CrossRefPubMedPubMedCentral

28.

Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA (2019) Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 16:605–616. https://doi.org/10.1038/s41575-019-0173-3CrossRefPubMed

29.

Korpela K, Helve O, Kolho KL, Saisto T, Skogberg K, Dikareva E, Stefanovic V, Salonen A, Andersson S, de Vos WM (2020) Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study. Cell 183:324-334.e325. https://doi.org/10.1016/j.cell.2020.08.047CrossRefPubMed

30.

Taur Y, Coyte K, Schluter J, Robilotti E, Figueroa C et al (2018) Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aap9489CrossRefPubMedPubMedCentral

31.

Guirro M, Costa A, Gual-Grau A, Herrero P, Torrell H, Canela N, Arola L (2019) Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: a multiomics approach. PLoS ONE 14:e0218143. https://doi.org/10.1371/journal.pone.0218143CrossRefPubMedPubMedCentral

32.

Staley C, Khoruts A, Sadowsky MJ (2017) Contemporary applications of fecal microbiota transplantation to treat intestinal diseases in humans. Arch Med Res 48:766–773. https://doi.org/10.1016/j.arcmed.2017.11.006CrossRefPubMed

33.

Tkach S, Dorofeyev A, Kuzenko I, Boyko N, Falalyeyeva T, Boccuto L, Scarpellini E, Kobyliak N, Abenavoli L (2022) Current status and future therapeutic options for fecal microbiota transplantation. Medicina. https://doi.org/10.3390/medicina58010084CrossRefPubMedPubMedCentral

34.

Juul FE, Garborg K, Bretthauer M, Skudal H, Øines MN, Wiig H, Rose Ø, Seip B, Lamont JT, Midtvedt T, Valeur J, Kalager M, Holme Ø, Helsingen L, Løberg M, Adami HO (2018) Fecal microbiota transplantation for primary clostridium difficile infection. N Engl J Med 378:2535–2536. https://doi.org/10.1056/NEJMc1803103CrossRefPubMed

35.

De Palma G, Lynch MD, Lu J, Dang VT, Deng Y et al (2017) Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aaf6397CrossRefPubMed

36.

Borody TJ, George L, Andrews P, Brandl S, Noonan S, Cole P, Hyland L, Morgan A, Maysey J, Moore-Jones D (1989) Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome? Med J Aust 150:604. https://doi.org/10.5694/j.1326-5377.1989.tb136704.xCrossRefPubMed

37.

Inflammatory Bowel Disease Group, Chinese Society of Gastroenterology, Chinese Medical Association (2021) Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing). J Dig Dis 22:298–317. https://doi.org/10.1111/1751-2980.12994CrossRef

38.

Cammarota G, Ianiro G, Tilg H, Rajilić-Stojanović M, Kump P et al (2017) European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66:569–580. https://doi.org/10.1136/gutjnl-2016-313017CrossRefPubMed

39.

Luz M, Waizbort RF (2020) Fecal microbiota transplants in the treatment of pseudomembranous colitis (1958–2013): priority of discovery and thought styles in the academic literature. Historia, Ciencias, Saude Manguinhos. 27:859–878. https://doi.org/10.1590/s0104-59702020000400009CrossRefPubMed

40.

Secombe KR, Al-Qadami GH, Subramaniam CB, Bowen JM, Scott J, Van Sebille YZA, Snelson M, Cowan C, Clarke G, Gheorghe CE, Cryan JF, Wardill HR (2021) Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols. Gut microbes 13:1979878. https://doi.org/10.1080/19490976.2021.1979878CrossRefPubMedPubMedCentral

41.

Cammarota G, Ianiro G, Kelly CR, Mullish BH, Allegretti JR et al (2019) International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. Gut 68:2111–2121. https://doi.org/10.1136/gutjnl-2019-319548CrossRefPubMed

42.

Bowden TA Jr, Mansberger AR Jr, Lykins LE (1981) Pseudomembraneous enterocolitis: mechanism for restoring floral homeostasis. Am Surg 47:178–183PubMed

43.

Schwan A, Sjölin S, Trottestam U, Aronsson B (1983) Relapsing clostridium difficile enterocolitis cured by rectal infusion of homologous faeces. Lancet 2:845. https://doi.org/10.1016/s0140-6736(83)90753-5CrossRefPubMed

44.

Bakken JS, Polgreen PM, Beekmann SE, Riedo FX, Streit JA (2013) Treatment approaches including fecal microbiota transplantation for recurrent Clostridium difficile infection (RCDI) among infectious disease physicians. Anaerobe 24:20–24. https://doi.org/10.1016/j.anaerobe.2013.08.007CrossRefPubMed

45.

Rinott E, Youngster I, Yaskolka Meir A, Tsaban G, Zelicha H et al (2021) Effects of diet-modulated autologous fecal microbiota transplantation on weight regain. Gastroenterology 160:158-173.e110. https://doi.org/10.1053/j.gastro.2020.08.041CrossRefPubMed

46.

Ma S, Wang N, Zhang P, Wu W, Fu L (2021) Fecal microbiota transplantation mitigates bone loss by improving gut microbiome composition and gut barrier function in aged rats. PeerJ 9:e12293. https://doi.org/10.7717/peerj.12293CrossRefPubMedPubMedCentral

47.

Aron-Wisnewsky J, Clément K, Nieuwdorp M (2019) Fecal microbiota transplantation: a future therapeutic option for obesity/diabetes? Curr DiabRep 19:51. https://doi.org/10.1007/s11892-019-1180-zCrossRef

48.

Lu C, Chen J, Yi C, Han J, Shi Q, Li J, Liu B, Zhou J, Su X (2021) Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice. Food Funct 12:5387–5398. https://doi.org/10.1039/d1fo00709bCrossRefPubMed

49.

Kragsnaes MS, Kjeldsen J, Horn HC, Munk HL, Pedersen JK, Just SA, Ahlquist P, Pedersen FM, de Wit M, Möller S, Andersen V, Kristiansen K, Kinggaard Holm D, Holt HM, Christensen R, Ellingsen T (2021) Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. Ann Rheum Dis 80:1158–1167. https://doi.org/10.1136/annrheumdis-2020-219511CrossRefPubMed

50.

Pennycook JH, Scanlan PD (2021) Ecological and evolutionary responses to antibiotic treatment in the human gut microbiota. FEMS Microbiol Rev. https://doi.org/10.1093/femsre/fuab018CrossRefPubMedPubMedCentral

51.

Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J, Belzer C, Delgado Palacio S, Arboleya Montes S, Mancabelli L, Lugli GA, Rodriguez JM, Bode L, de Vos W, Gueimonde M, Margolles A, van Sinderen D, Ventura M (2017) The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev MMBR. https://doi.org/10.1128/mmbr.00036-17CrossRefPubMed

52.

Loo YT, Howell K, Chan M, Zhang P, Ng K (2020) Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods. Compr Rev Food Sci Food Safety 19:1268–1298. https://doi.org/10.1111/1541-4337.12563CrossRef

53.

Ling CW, Miao Z, Xiao ML, Zhou H, Jiang Z et al (2021) The association of gut microbiota with osteoporosis is mediated by amino acid metabolism: multiomics in a large cohort. J Clin Endocrinol Metab 106:e3852–e3864. https://doi.org/10.1210/clinem/dgab492CrossRefPubMed

54.

Jia X, Jia L, Mo L, Yuan S, Zheng X, He J, Chen V, Guo Q, Zheng L, Yuan Q, Xu X, Zhou X (2019) Berberine ameliorates periodontal bone loss by regulating gut microbiota. J Dent Res 98:107–116. https://doi.org/10.1177/0022034518797275CrossRefPubMed

55.

Lu L, Tang M, Li J, Xie Y, Li Y, Xie J, Zhou L, Liu Y, Yu X (2021) Gut microbiota and serum metabolic signatures of high-fat-induced bone loss in mice. Front Cell Infect Microbiol 11:788576. https://doi.org/10.3389/fcimb.2021.788576CrossRefPubMedPubMedCentral

56.

Tu MY, Han KY, Chang GR, Lai GD, Chang KY, Chen CF, Lai JC, Lai CY, Chen HL, Chen CM (2020) Kefir peptides prevent estrogen deficiency-induced bone loss and modulate the structure of the gut microbiota in ovariectomized mice. Nutrients. https://doi.org/10.3390/nu12113432CrossRefPubMedPubMedCentral

57.

Liu H, Gu R, Zhu Y, Lian X, Wang S, Liu X, Ping Z, Liu Y, Zhou Y (2020) D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis 11:2040622320912661. https://doi.org/10.1177/2040622320912661CrossRefPubMedPubMedCentral

58.

Jia L, Tu Y, Jia X, Du Q, Zheng X, Yuan Q, Zheng L, Zhou X, Xu X (2021) Probiotics ameliorate alveolar bone loss by regulating gut microbiota. Cell Prolif 54:e13075. https://doi.org/10.1111/cpr.13075CrossRefPubMedPubMedCentral

59.

Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF (2016) Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci USA 113:E7554-e7563. https://doi.org/10.1073/pnas.1607235113CrossRefPubMedPubMedCentral

60.

Sjögren K, Engdahl C, Henning P, Lerner UH, Tremaroli V, Lagerquist MK, Bäckhed F, Ohlsson C (2012) The gut microbiota regulates bone mass in mice. J Bone Miner Res 27:1357–1367. https://doi.org/10.1002/jbmr.1588CrossRefPubMed

61.

Huo R, Zeng B, Zeng L, Cheng K, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H, Xie P (2017) Microbiota modulate anxiety-like behavior and endocrine abnormalities in hypothalamic-pituitary-adrenal axis. Front Cell Infect Microbiol 7:489. https://doi.org/10.3389/fcimb.2017.00489CrossRefPubMedPubMedCentral

62.

Han H, Yi B, Zhong R, Wang M, Zhang S, Ma J, Yin Y, Yin J, Chen L, Zhang H (2021) From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators. Microbiome 9:162. https://doi.org/10.1186/s40168-021-01093-yCrossRefPubMedPubMedCentral

63.

Qi X, Yun C, Pang Y, Qiao J (2021) The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut microbes 13:1–21. https://doi.org/10.1080/19490976.2021.1894070CrossRefPubMed

64.

Fuhrman BJ, Feigelson HS, Flores R, Gail MH, Xu X, Ravel J, Goedert JJ (2014) Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women. J Clin Endocrinol Metab 99:4632–4640. https://doi.org/10.1210/jc.2014-2222CrossRefPubMedPubMedCentral

65.

Tousen Y, Uehara M, Abe F, Kimira Y, Ishimi Y (2013) Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study. Nutr J 12:127. https://doi.org/10.1186/1475-2891-12-127CrossRefPubMedPubMedCentral

66.

Cronin BE, Allsopp PJ, Slevin MM, Magee PJ, Livingstone MB, Strain JJ, McSorley EM (2016) Effects of supplementation with a calcium-rich marine-derived multi-mineral supplement and short-chain fructo-oligosaccharides on serum lipids in postmenopausal women. Br J Nutr 115:658–665. https://doi.org/10.1017/s0007114515004948CrossRefPubMed

67.

Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ (2005) A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr 82:471–476. https://doi.org/10.1093/ajcn.82.2.471CrossRefPubMed

68.

van den Heuvel EG, Schoterman MH, Muijs T (2000) Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women. J Nutr 130:2938–2942. https://doi.org/10.1093/jn/130.12.2938CrossRefPubMed

69.

Jones ML, Martoni CJ, Prakash S (2013) Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab 98:2944–2951. https://doi.org/10.1210/jc.2012-4262CrossRefPubMed

70.

Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment N, Liu XS, Yang S, Choi Y, Ahn J, Qin L (2021) Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Investig. https://doi.org/10.1172/jci140214CrossRefPubMedPubMedCentral

71.

Sun J, Xu J, Ling Y, Wang F, Gong T, Yang C, Ye S, Ye K, Wei D, Song Z, Chen D, Liu J (2019) Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice. Transl Psychiatry 9:189. https://doi.org/10.1038/s41398-019-0525-3CrossRefPubMedPubMedCentral

72.

Kim JH, Kim K, Kim W (2021) Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy. Exp Mol Med 53:907–916. https://doi.org/10.1038/s12276-021-00627-6CrossRefPubMedPubMedCentral

73.

Bajaj JS, Gavis EA, Fagan A, Wade JB, Thacker LR, Fuchs M, Patel S, Davis B, Meador J, Puri P, Sikaroodi M, Gillevet PM (2021) A randomized clinical trial of fecal microbiota transplant for alcohol use disorder. Hepatology 73:1688–1700. https://doi.org/10.1002/hep.31496CrossRefPubMed

74.

Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, Rabinowitz JD, Wellen KE (2020) Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579:586–591. https://doi.org/10.1038/s41586-020-2101-7CrossRefPubMedPubMedCentral

75.

Chen B, Wei J, Zhu R, Zhang H, Xia B, Liu Y, Dai X, Ye Z, Tian Y, Li R, Zhao D, Mo F, Orekhov AN, Gao S, Brὃmme D, Wang L, Zhang D (2021) Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats. J Ethnopharmacol 279:114348. https://doi.org/10.1016/j.jep.2021.114348CrossRefPubMed

76.

Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J, Kim CH (2015) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 8:80–93. https://doi.org/10.1038/mi.2014.44CrossRefPubMed

77.

Beilharz JE, Kaakoush NO, Maniam J, Morris MJ (2018) Cafeteria diet and probiotic therapy: cross talk among memory, neuroplasticity, serotonin receptors and gut microbiota in the rat. Mol Psychiatry 23:351–361. https://doi.org/10.1038/mp.2017.38CrossRefPubMed

78.

Esmaili A, Nazir SF, Borthakur A, Yu D, Turner JR, Saksena S, Singla A, Hecht GA, Alrefai WA, Gill RK (2009) Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology 137:2074–2083. https://doi.org/10.1053/j.gastro.2009.09.002CrossRefPubMed

79.

Wang H, Liu W, Shi F, Huang L, Lian J, Qu L, Cai J, Xu Z (2018) Metabolic pathway engineering for high-level production of 5-hydroxytryptophan in Escherichia coli. Metab Eng 48:279–287. https://doi.org/10.1016/j.ymben.2018.06.007CrossRefPubMed

80.

Hodge JM, Wang Y, Berk M, Collier FM, Fernandes TJ, Constable MJ, Pasco JA, Dodd S, Nicholson GC, Kennedy RL, Williams LJ (2013) Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiat 74:32–39. https://doi.org/10.1016/j.biopsych.2012.11.003CrossRefPubMed

81.

Rizzoli R, Biver E (2020) Are probiotics the new calcium and vitamin D for bone health? Curr Osteoporos Rep 18:273–284. https://doi.org/10.1007/s11914-020-00591-6CrossRefPubMed

82.

Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, Ackermann G, Vanderschueren D, Pauwels S, Knight R, Orwoll ES, Kado DM (2020) Vitamin D metabolites and the gut microbiome in older men. Nat Commun 11:5997. https://doi.org/10.1038/s41467-020-19793-8CrossRefPubMedPubMedCentral

83.

Feng YL, Cao G, Chen DQ, Vaziri ND, Chen L, Zhang J, Wang M, Guo Y, Zhao YY (2019) Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease. Cell Mol Life Sci 76:4961–4978. https://doi.org/10.1007/s00018-019-03155-9CrossRefPubMed

84.

Raya-Sandino A, Luissint AC, Kusters DHM, Narayanan V, Flemming S, Garcia-Hernandez V, Godsel LM, Green KJ, Hagen SJ, Conway DE, Parkos CA, Nusrat A (2021) Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Mol Biol Cell 32:753–768. https://doi.org/10.1091/mbc.E20-12-0775CrossRefPubMedPubMedCentral

85.

Pontarollo G, Mann A, Brandão I, Malinarich F, Schöpf M, Reinhardt C (2020) Protease-activated receptor signaling in intestinal permeability regulation. FEBS J 287:645–658. https://doi.org/10.1111/febs.15055CrossRefPubMed

86.

Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG, De Winter BY (2017) Regulation of intestinal permeability: the role of proteases. World J Gastroenterol 23:2106–2123. https://doi.org/10.3748/wjg.v23.i12.2106CrossRefPubMedPubMedCentral

87.

Schepper JD, Collins FL, Rios-Arce ND, Raehtz S, Schaefer L, Gardinier JD, Britton RA, Parameswaran N, McCabe LR (2019) Probiotic lactobacillus reuteri prevents postantibiotic bone loss by reducing intestinal dysbiosis and preventing barrier disruption. J Bone Miner Res 34:681–698. https://doi.org/10.1002/jbmr.3635CrossRefPubMed

88.

Chen X, Zhang Z, Hu Y, Cui J, Zhi X, Li X, Jiang H, Wang Y, Gu Z, Qiu Z, Dong X, Li Y, Su J (2020) Lactulose suppresses osteoclastogenesis and ameliorates estrogen deficiency-induced bone loss in mice. Aging Dis 11:629–641. https://doi.org/10.14336/ad.2019.0613CrossRefPubMed

89.

Li B, Liu M, Wang Y, Gong S, Yao W, Li W, Gao H, Wei M (2020) Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity. Biomed Pharmacother 132:110923. https://doi.org/10.1016/j.biopha.2020.110923CrossRefPubMed

90.

Li J, Yang M, Lu C, Han J, Tang S, Zhou J, Li Y, Ming T, Wang ZJ, Su X (2020) Tuna bone powder alleviates glucocorticoid-induced osteoporosis via coregulation of the NF-κB and Wnt/β-catenin signaling pathways and modulation of gut microbiota composition and metabolism. Mol Nutr Food Res 64:e1900861. https://doi.org/10.1002/mnfr.201900861CrossRefPubMed

91.

Wang Z, Chen K, Wu C, Chen J, Pan H, Liu Y, Wu P, Yuan J, Huang F, Lang J, Du J, Xu J, Jin K, Chen L (2021) An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice. Am J Clin Nutr 114:1304–1313. https://doi.org/10.1093/ajcn/nqab194CrossRefPubMed

92.

Wang N, Ma S, Fu L (2022) Gut microbiota dysbiosis as one cause of osteoporosis by impairing intestinal barrier function. Calcif Tissue Int 110:225–235. https://doi.org/10.1007/s00223-021-00911-7CrossRefPubMed

93.

Zhang Y-W, Cao M-M, Li Y-J, Lu P-P, Dai G-C, Zhang M, Wang H, Rui Y-F (2022) Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function. J Orthop Transl 37:46–60. https://doi.org/10.1016/j.jot.2022.08.003CrossRef

94.

Tsukasaki M, Takayanagi H (2019) Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol 19:626–642. https://doi.org/10.1038/s41577-019-0178-8CrossRefPubMed

95.

Liu YJ, Tang B, Wang FC, Tang L, Lei YY, Luo Y, Huang SJ, Yang M, Wu LY, Wang W, Liu S, Yang SM, Zhao XY (2020) Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner. Theranostics 10:5225–5241. https://doi.org/10.7150/thno.43716CrossRefPubMedPubMedCentral

96.

Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331:337–341. https://doi.org/10.1126/science.1198469CrossRefPubMed

97.

Yu M, Pal S, Paterson CW, Li JY, Tyagi AM, Adams J, Coopersmith CM, Weitzmann MN, Pacifici R (2021) Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells. J Clin Investig. https://doi.org/10.1172/jci143137CrossRefPubMedPubMedCentral

98.

Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II (2014) Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40:594–607. https://doi.org/10.1016/j.immuni.2014.03.005CrossRefPubMedPubMedCentral

99.

Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485–498. https://doi.org/10.1016/j.cell.2009.09.033CrossRefPubMedPubMedCentral

100.

Han Q, Wang J, Li W, Chen ZJ, Du Y (2021) Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome. Microbiome 9:101. https://doi.org/10.1186/s40168-021-01046-5CrossRefPubMedPubMedCentral

101.

Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108:16050–16055. https://doi.org/10.1073/pnas.1102999108CrossRefPubMedPubMedCentral

102.

Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG (2014) Minireview: gut microbiota: the neglected endocrine organ. Mol Endocrinol 28:1221–1238. https://doi.org/10.1210/me.2014-1108CrossRefPubMedPubMedCentral

103.

Schepper JD, Collins F, Rios-Arce ND, Kang HJ, Schaefer L, Gardinier JD, Raghuvanshi R, Quinn RA, Britton R, Parameswaran N, McCabe LR (2020) Involvement of the gut microbiota and barrier function in glucocorticoid-induced osteoporosis. J Bone Miner Res 35:801–820. https://doi.org/10.1002/jbmr.3947CrossRefPubMed

104.

Honda K, Littman DR (2016) The microbiota in adaptive immune homeostasis and disease. Nature 535:75–84. https://doi.org/10.1038/nature18848CrossRefPubMed

105.

Zhong M, Buch H, Wen Q, Long C, Cui B, Zhang F (2021) Colonic transendoscopic enteral tubing: route for a novel, safe, and convenient delivery of washed microbiota transplantation in children. Gastroenterol Res Pract 2021:6676962. https://doi.org/10.1155/2021/6676962CrossRefPubMedPubMedCentral

106.

Zhang T, Long C, Cui B, Buch H, Wen Q, Li Q, Ding X, Ji G, Zhang F (2020) Colonic transendoscopic tube-delivered enteral therapy (with video): a prospective study. BMC Gastroenterol 20:135. https://doi.org/10.1186/s12876-020-01285-0CrossRefPubMedPubMedCentral

107.

Long C, Yu Y, Cui B, Jagessar SAR, Zhang J, Ji G, Huang G, Zhang F (2018) A novel quick transendoscopic enteral tubing in mid-gut: technique and training with video. BMC Gastroenterol 18:37. https://doi.org/10.1186/s12876-018-0766-2CrossRefPubMedPubMedCentral

108.

Woodworth MH, Neish EM, Miller NS, Dhere T, Burd EM, Carpentieri C, Sitchenko KL, Kraft CS (2017) Laboratory testing of donors and stool samples for fecal microbiota transplantation for recurrent clostridium difficile infection. J Clin Microbiol 55:1002–1010. https://doi.org/10.1128/jcm.02327-16CrossRefPubMedPubMedCentral

109.

Papanicolas LE, Wang Y, Choo JM, Gordon DL, Wesselingh SL, Rogers GB (2019) Optimisation of a propidium monoazide based method to determine the viability of microbes in faecal slurries for transplantation. J Microbiol Methods 156:40–45. https://doi.org/10.1016/j.mimet.2018.12.001CrossRefPubMed

110.

Ramai D, Zakhia K, Ofosu A, Ofori E, Reddy M (2019) Fecal microbiota transplantation: donor relation, fresh or frozen, delivery methods, cost-effectiveness. Ann Gastroenterol 32:30–38. https://doi.org/10.20524/aog.2018.0328CrossRefPubMed

111.

Fuentes S, de Vos WM (2016) How to manipulate the microbiota: fecal microbiota transplantation. Adv Exp Med Biol 902:143–153. https://doi.org/10.1007/978-3-319-31248-4_10CrossRefPubMed

112.

Ng SC, Kamm MA, Yeoh YK, Chan PKS, Zuo T, Tang W, Sood A, Andoh A, Ohmiya N, Zhou Y, Ooi CJ, Mahachai V, Wu CY, Zhang F, Sugano K, Chan FKL (2020) Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE). Gut 69:83–91. https://doi.org/10.1136/gutjnl-2019-319407CrossRefPubMed

113.

Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P, Katsikeros R, Makanyanga J, Campaniello MA, Mavrangelos C, Rosewarne CP, Bickley C, Peters C, Schoeman MN, Conlon MA, Roberts-Thomson IC, Andrews JM (2019) Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA 321:156–164. https://doi.org/10.1001/jama.2018.20046CrossRefPubMedPubMedCentral

114.

Khanna S, Pardi DS, Kelly CR, Kraft CS, Dhere T, Henn MR, Lombardo MJ, Vulic M, Ohsumi T, Winkler J, Pindar C, McGovern BH, Pomerantz RJ, Aunins JG, Cook DN, Hohmann EL (2016) A novel microbiome therapeutic increases gut microbial diversity and prevents recurrent clostridium difficile infection. J Infect Dis 214:173–181. https://doi.org/10.1093/infdis/jiv766CrossRefPubMed

115.

Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL (2014) Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312:1772–1778. https://doi.org/10.1001/jama.2014.13875CrossRefPubMed

116.

Wen Q, Liu KJ, Cui BT, Li P, Wu X, Zhong M, Wei L, Tu H, Yuan Y, Lin D, Hsu WH, Wu DC, Yin H, Zhang FM (2020) Impact of cap-assisted colonoscopy during transendoscopic enteral tubing: a randomized controlled trial. World J Gastroenterol 26:6098–6110. https://doi.org/10.3748/wjg.v26.i39.6098CrossRefPubMedPubMedCentral

117.

van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG, Speelman P, Dijkgraaf MG, Keller JJ (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368:407–415. https://doi.org/10.1056/NEJMoa1205037CrossRefPubMed

118.

Zhong M, Sun Y, Wang HG, Marcella C, Cui BT, Miao YL, Zhang FM (2020) Awareness and attitude of fecal microbiota transplantation through transendoscopic enteral tubing among inflammatory bowel disease patients. World J Clin Cases 8:3786–3796. https://doi.org/10.12998/wjcc.v8.i17.3786CrossRefPubMedPubMedCentral

119.

Ding X, Li Q, Li P, Zhang T, Cui B, Ji G, Lu X, Zhang F (2019) Long-term safety and efficacy of fecal microbiota transplant in active ulcerative colitis. Drug Saf 42:869–880. https://doi.org/10.1007/s40264-019-00809-2CrossRefPubMed

120.

Liu J, Miyake H, Zhu H, Li B, Alganabi M, Lee C, Pierro A (2020) Fecal microbiota transplantation by enema reduces intestinal injury in experimental necrotizing enterocolitis. J Pediatr Surg 55:1094–1098. https://doi.org/10.1016/j.jpedsurg.2020.02.035CrossRefPubMed

121.

Hsu WH, Wang JY, Kuo CH (2019) Current applications of fecal microbiota transplantation in intestinal disorders. Kaohsiung J Med Sci 35:327–331. https://doi.org/10.1002/kjm2.12069CrossRefPubMed

122.

Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, Chang HJ, Coward S, Goodman KJ, Xu H, Madsen K, Mason A, Wong GK, Jovel J, Patterson J, Louie T (2017) Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent clostridium difficile infection: a randomized clinical trial. JAMA 318:1985–1993. https://doi.org/10.1001/jama.2017.17077CrossRefPubMedPubMedCentral

123.

Lahtinen P, Jalanka J, Hartikainen A, Mattila E, Hillilä M, Punkkinen J, Koskenpato J, Anttila VJ, Tillonen J, Satokari R, Arkkila P (2020) Randomised clinical trial: faecal microbiota transplantation versus autologous placebo administered via colonoscopy in irritable bowel syndrome. Aliment Pharmacol Ther 51:1321–1331. https://doi.org/10.1111/apt.15740CrossRefPubMed

124.

Hanssen NMJ, de Vos WM, Nieuwdorp M (2021) Fecal microbiota transplantation in human metabolic diseases: from a murky past to a bright future? Cell Metab 33:1098–1110. https://doi.org/10.1016/j.cmet.2021.05.005CrossRefPubMed

125.

Holvoet T, Joossens M, Vázquez-Castellanos JF, Christiaens E, Heyerick L, Boelens J, Verhasselt B, van Vlierberghe H, De Vos M, Raes J, De Looze D (2021) Fecal microbiota transplantation reduces symptoms in some patients with irritable bowel syndrome with predominant abdominal bloating: short- and long-term results from a placebo-controlled randomized trial. Gastroenterology 160:145-157.e148. https://doi.org/10.1053/j.gastro.2020.07.013CrossRefPubMed

126.

Wang H, Cui B, Li Q, Ding X, Li P, Zhang T, Yang X, Ji G, Zhang F (2018) The safety of fecal microbiota transplantation for crohn’s disease: findings from a long-term study. Adv Ther 35:1935–1944. https://doi.org/10.1007/s12325-018-0800-3CrossRefPubMedPubMedCentral

127.

Khoruts A, Sadowsky MJ, Hamilton MJ (2015) Development of fecal microbiota transplantation suitable for mainstream medicine. Clin Gastroenterol Hepatol 13:246–250. https://doi.org/10.1016/j.cgh.2014.11.014CrossRefPubMed

128.

Paramsothy S, Walsh AJ, Borody T, Samuel D, van den Bogaerde J, Leong RW, Connor S, Ng W, Mitchell HM, Kaakoush NO, Kamm MA (2015) Gastroenterologist perceptions of faecal microbiota transplantation. World J Gastroenterol 21:10907–10914. https://doi.org/10.3748/wjg.v21.i38.10907CrossRefPubMedPubMedCentral

129.

Nicholson MR, Hourigan SK, Conrad M, Goyal A, Jensen K, Kelsen J, Kennedy M, Weatherly M, Kahn SA (2021) Current challenges in fecal microbiota transplantation for clostridioides difficile infection in children. Am J Gastroenterol 116:1954–1956. https://doi.org/10.14309/ajg.0000000000001350CrossRefPubMedPubMedCentral

130.

Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H (2020) Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology 158:1831-1833.e1833. https://doi.org/10.1053/j.gastro.2020.02.055CrossRefPubMed

131.

DeFilipp Z, Bloom PP, Torres Soto M, Mansour MK, Sater MRA, Huntley MH, Turbett S, Chung RT, Chen YB, Hohmann EL (2019) Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant. New Engl J Med 381:2043–2050. https://doi.org/10.1056/NEJMoa1910437CrossRefPubMed

132.

Zhang L, Ghosh SK, Basavarajappa SC, Chen Y, Shrestha P, Penfield J, Brewer A, Ramakrishnan P, Buck M, Weinberg A (2022) HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: strategy to combat COVID-19. iScience 25:103856. https://doi.org/10.1016/j.isci.2022.103856CrossRefPubMedPubMedCentral

133.

Sekar PC, Srinivasan E, Chandrasekhar G, Paul DM, Sanjay G, Surya S, Kumar N, Rajasekaran R (2022) Probing the competitive inhibitor efficacy of frog-skin alpha helical AMPs identified against ACE2 binding to SARS-CoV-2 S1 spike protein as therapeutic scaffold to prevent COVID-19. J Mol Model 28:128. https://doi.org/10.1007/s00894-022-05117-8CrossRefPubMedPubMedCentral

134.

Ianiro G, Mullish BH, Kelly CR, Kassam Z, Kuijper EJ et al (2020) Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic. Gut 69:1555–1563. https://doi.org/10.1136/gutjnl-2020-321829CrossRefPubMed

135.

Khanna S, Tande A, Rubin DT, Khoruts A, Kahn SA, Pardi DS (2021) Fecal microbiota transplantation for recurrent c difficile infection during the COVID-19 pandemic: experience and recommendations. Mayo Clin Proc 96:1418–1425. https://doi.org/10.1016/j.mayocp.2021.04.005CrossRefPubMed

136.

Shahinas D, Silverman M, Sittler T, Chiu C, Kim P, Allen-Vercoe E, Weese S, Wong A, Low DE, Pillai DR (2012) Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing. iBio. https://doi.org/10.1128/mBio.00338-12CrossRef

137.

Lagier JC (2014) Faecal microbiota transplantation: from practice to legislation before considering industrialization. Clin Microbiol Infect 20:1112–1118. https://doi.org/10.1111/1469-0691.12795CrossRefPubMed

138.

Khan R, Roy N, Ali H, Naeem M (2022) Fecal microbiota transplants for inflammatory bowel disease treatment: synthetic- and engineered communities-based microbiota transplants are the future. Gastroenterol Res Pract 2022:9999925. https://doi.org/10.1155/2022/9999925CrossRefPubMedPubMedCentral

139.

Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcella C, Cui B, Cheng L, Ji G, Zhang F (2020) Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell 11:251–266. https://doi.org/10.1007/s13238-019-00684-8CrossRefPubMedPubMedCentral

140.

Zhang T, Li P, Wu X, Lu G, Marcella C, Ji X, Ji G, Zhang F (2020) Alterations of Akkermansia muciniphila in the inflammatory bowel disease patients with washed microbiota transplantation. Appl Microbiol Biotechnol 104:10203–10215. https://doi.org/10.1007/s00253-020-10948-7CrossRefPubMed

141.

Colman RJ, Rubin DT (2014) Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 8:1569–1581. https://doi.org/10.1016/j.crohns.2014.08.006CrossRefPubMed

142.

Haifer C, Kelly CR, Paramsothy S, Andresen D, Papanicolas LE et al (2020) Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice. Gut 69:801–810. https://doi.org/10.1136/gutjnl-2019-320260CrossRefPubMed

Titel: Fecal microbiota transplantation as a promising treatment option for osteoporosis
verfasst von: Yuan-Wei Zhang
Mu-Min Cao
Ying-Juan Li
Ruo-Lan Zhang
Meng-Ting Wu
Qian Yu
Yun-Feng Rui
Publikationsdatum: 11.11.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 6/2022
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-022-01375-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

Antikörper mobilisiert Neutrophile gegen Krebs

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2022

Risk factors for poor response to denosumab treatment in Japanese postmenopausal women with osteoporosis

Journal of Bone and Mineral Metabolism Best Paper Award 2022

Study on mass transfer in the bone lacunar-canalicular system under different gravity fields

List of reviewers 2021–2022

A novel serological biomarker are associated with disease severity in patients with osteoarthritis

Bone mass and biomarkers in young women with anorexia nervosa: a prospective 3-year follow-up study

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

Antikörper mobilisiert Neutrophile gegen Krebs

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Update Innere Medizin