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Clinical Reviews in Allergy & Immunology

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29.01.2024 | Review

Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?

verfasst von: Kripa Ahuja, Christopher J. Issa, Susan T. Nedorost, Peter A. Lio

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2024

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Abstract

Food allergy in atopic dermatitis is mediated by complex immune interactions between genetics, diet, environment, and the microbiome. When contact between inflamed skin and food antigens occurs, contact hypersensitivity can develop. Consequently, systemic contact dermatitis (SCD) can occur after ingestion of allergenic foods or food additives in the setting of a Th2 response with CLA-positive T cells, triggering dermatitis where skin resident memory lymphocytes reside. This phenomenon explains food-triggered dermatitis. Atopy patch tests (APTs) detect sensitization to food proteins responsible for SCD, which in turn can be confirmed by oral food challenge with delayed interpretation. We summarize the literature on using APTs to identify foods for oral challenge with dermatitis as an outcome. In dermatitis patients at risk for Th2 skewing based on a history of childhood-onset flexural dermatitis, shared decision-making should include a discussion of identifying and avoiding food and food additive triggers, as well as identifying and avoiding all contact allergens, prior to initiation of systemic therapy for dermatitis.

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Titel: Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?
verfasst von: Kripa Ahuja
Christopher J. Issa
Susan T. Nedorost
Peter A. Lio
Publikationsdatum: 29.01.2024
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2024
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-023-08977-x

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Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?

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