Acute kidney injury (AKI) is a heterogeneous group of serious conditions characterised by a rapid decrease in the glomerular filtration rate (GFR) and/or renal output [ 1 , 2 ]. AKI affects approximately 10–15% of adults admitted to hospital [ 1 …
Chronic kidney disease (CKD) has become a major global health problem, with a prevalence of 8–16% among the general population [ 1 – 3 ]. Comorbidities related to CKD, such as end-stage renal disease and cardiovascular diseases, are associated with …
Diabetes mellitus (DM) is a severe and chronic disorder with the characteristic of high blood glucose levels. It has supported that there are 537 million diabetes adults worldwide based on the International Diabetes Federation Diabetes Atlas (10th …
verfasst von:
Lang Han, Xiaojiao Chen, Dianwei Wan, Min Xie, Shurui Ouyang
Chronic kidney disease (CKD) is an urgent issue that needs to be addressed as the number of patients requiring dialysis is increasing worldwide. It is a serious risk factor for cardiovascular diseases and has a significant impact on the health of …
Renal anemia is a common comorbidity of advanced chronic kidney disease (CKD) [ 1 ]. Anemia associated with CKD can cause heart failure and exacerbate CKD [ 2 ]. In 1996, erythropoiesis-stimulating agents (ESAs) were introduced to treat renal …
IgAN is the most common primary glomerular disease in the world, and approximately 30% of IgAN patients gradually progress to ESRD 20 years after diagnosis, which brings an enormous psychological and economic burden to patients [ 1 ], and IgAN is …
Polycystic kidney disease (PKD) is a genetically heterogenous class of kidney disease with diverse clinical manifestations, commonly characterized by progressive development of kidney cysts [ 1 ]. Polycystic kidney disease is mainly classified as …
Primary membranous nephropathy (PMN) is an autoimmune disease characterized by thickening of the glomerular basement membrane caused by the deposition of immune complex. It is one of the common cause of adult nephrotic syndrome, and its prevalence …
verfasst von:
Min Li, Xiaoying Lai, Jun Liu, Yahuan Yu, Xianyi Li, Xuemei Liu
Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening systemic disease generally resulting from dysregulation of the alternative complement system. Previous studies reported genetic and/or autoimmune abnormalities causing …
verfasst von:
Kubra Celegen, Bora Gulhan, Kibriya Fidan, Selcuk Yuksel, Neslihan Yilmaz, Aysun Caltik Yılmaz, Beltinge Demircioğlu Kılıç, Ibrahim Gokce, Aslı Kavaz Tufan, Mukaddes Kalyoncu, Hulya Nalcacıoglu, Sare Gulfem Ozlu, Eda Didem Kurt Sukur, Nur Canpolat, Aysun K. Bayazit, Elif Çomak, Yılmaz Tabel, Sebahat Tulpar, Mehtap Celakil, Kenan Bek, Cengiz Zeybek, Ali Duzova, Birsin Ozcakar, Rezan Topaloglu, Oguz Soylemezoglu, Fatih Ozaltin
In the beginning of 2020, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified as the causative agent of pneumonia outbreak in China. Within a short period of time, thousands of humans all over the world were infected as a …
verfasst von:
Yasmine Salah Naga, Ahmed El Keraie, Samar Samy Abd ElHafeez, Rowan Saad Zyada
Cisplatin (CP) is a chemotherapy drug widely prescribed to treat various neoplasms. Although fundamental for the therapeutic action of the drug, its cytotoxic mechanisms trigger adverse effects in several tissues, such as the kidney, liver, and …
verfasst von:
Caroline Assunção Oliveira, Érika Azenathe Barros Mercês, Fernanda Santos Portela, Lara Fabiana Luz Malheiro, Henrique Bruno Lopes Silva, Laís Mafra De Benedictis, Júlia Mafra De Benedictis, Clara Cotta d’Ávilla e Silva, Alberto Christian Luz Santos, Dã Pinheiro Rosa, Helloisa Souza Velozo, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Chronic kidney disease constitutes a major public health concern, associated with high morbidity and mortality rates. Its incidence is rising, affecting more than 10% of the global population [ 1 ]. It represents an important cause of death and by …
verfasst von:
Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Vassiliki Benetou
Alport syndrome (AS) is a genetic disease characterized by progressive kidney dysfunction, hearing loss, and ocular abnormalities. AS is caused by a mutation in one of the type IV collagen genes, COL4A3 , COL4A4, and COL4A5 that encodes …
verfasst von:
Yuimi Koyama, Mary Ann Suico, Aimi Owaki, Ryoichi Sato, Jun Kuwazuru, Shota Kaseda, Yuya Sannomiya, Jun Horizono, Kohei Omachi, Tomoko Horinouchi, Tomohiko Yamamura, Haruki Tsuhako, Kandai Nozu, Tsuyoshi Shuto, Hirofumi Kai
Kidney transplantation (KT) is the optimal treatment option for most patients with end-stage renal disease, offering improved life expectancy, enhanced quality of life, and reduced metabolic disorders or symptoms associated with hemodialysis, such …
Acute kidney injury (AKI) is a cluster of clinical syndromes with diverse etiologies that ultimately result in a swift decline in kidney function. Regrettably, AKI lacks effective therapeutic agents at present. Neferine, a bioactive alkaloid …
verfasst von:
Yanying Xiong, Jin Zhong, Wenhang Chen, Xuan Li, Hong Liu, Ying Li, Weijian Xiong, Huihui Li
Ferroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes …
Chronic kidney disease (CKD) is a disease for which continuous multidisciplinary care, including nephrologists, nurses, pharmacists, and dietitians, is important. Multidisciplinary care for CKD has been reported to prevent deterioration of renal …
verfasst von:
Natsuko Okuno, Hiroshi Kado, Hiroyoshi Segawa, Tsuguru Hatta
Chronic kidney disease (CKD) represents a substantial clinical and public health challenge due to its escalating incidence and prevalence rates. It stands as a prominent contributor to both morbidity and mortality associated with end-stage renal …
verfasst von:
Xuerui Yang, Jun Yang, Youjia Zeng, Ling Peng, Xingzheng Liu, Jinying Mo, Taifen Wang, Yutong Yao, Yihou Zheng, Gaofeng Song
Although kidney transplantation is described as an effective treatment modality for patients with end-stage kidney disease (ESKD), the shortage of organ donations is critical problem in Japan [ 1 ]. According to a report from the International …
In solid organ transplant (SOT) recipients receiving immunosuppressive drugs, cytomegalovirus (CMV) disease is associated with substantial morbidity and mortality [ 1 , 2 ]. Direct (CMV syndrome, end-organ disease) and indirect (e.g., allograft …
verfasst von:
Hideki Ishida, Norihiko Goto, Ryoichi Imamura, Hajime Sasaki, Kohei Unagami, Kenta Futamura, Yoshihiko Murata, Nobuyuki Oshima, Toshiko Eto, Barbara Haber
