Glioblastoma is the most prevalent and aggressive glioma, accounting for 12–15% of all intracranial tumors and 50–60% of glioma [ 1 ]. The incidence of glioblastoma increases with age from 0.15 per 100,000 in children compared to 15.3 per 100,000 …
Frailty is a state of vulnerability due to impairments in multiple organ systems resulting in an increased risk of morbidity and mortality [ 1 , 2 ]. Frailty is significantly associated with worse postoperative outcomes and with increased risks of …
verfasst von:
Benoît Hudelist, Angela Elia, Alexandre Roux, Luca Paun, Xavier Schumacher, Meissa Hamza, Marco Demasi, Alessandro Moiraghi, Edouard Dezamis, Fabrice Chrétien, Joseph Benzakoun, Catherine Oppenheim, Marc Zanello, Johan Pallud
Glioblastoma (GBM) is an aggressive and incurable primary brain tumor; median overall survival (mOS) in unselected patients is approximately 12 months [ 1 , 2 ]. Treatment is multimodal; after surgery patients are scheduled for chemoradiotherapy.
verfasst von:
Hanne Blakstad, Eduardo Erasmo Mendoza Mireles, Kirsten Strømme Kierulf-Vieira, Divija Singireddy, Ibrahimu Mdala, Liv Cathrine Heggebø, Henriette Magelssen, Mette Sprauten, Tom Børge Johannesen, Henning Leske, Pitt Niehusmann, Karoline Skogen, Eirik Helseth, Kyrre Eeg Emblem, Einar O. Vik-Mo, Petter Brandal
Pituitary adenomas (PAs) are benign tumors arising from the anterior pituitary, with an incidence of 3.9–7.4/100.000/year and a prevalence of 76–116/100.000/year [ 1 – 3 ]. A histological classification is based on pituitary hormone content as …
verfasst von:
Cristina Capatina, Felicia Alexandra Hanzu, José Miguel Hinojosa-Amaya, Maria Fleseriu
Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro, Netanel Ben-Shalom, Randy S. D’Amico, Manju Harshan, Amy McKeown, Avraham Zlochower, David J. Langer, John A. Boockvar
Primary tumors of the central nervous system (CNS) are amongst the most common neoplasms and are the leading cause of disease-related death in children [ 1 ]. The histologic and molecular makeup of these CNS neoplasms differs substantially from …
verfasst von:
Rebecca Ronsley, Kristine A. Karvonen, Bonnie Cole, Vera Paulson, Jeff Stevens, Erin E. Crotty, Jason Hauptman, Amy Lee, Shannon M. Stasi, Christina M. Lockwood, Sarah E. S. Leary
Radiotherapy, with or without surgery and chemotherapy, forms an integral part of the treatment paradigm for most malignant and many benign brain tumors [ 1 ]. The effects of treatment on the normal brain, including adverse radiation effects (ARE) …
verfasst von:
Victor Goulenko, Venkatesh Shankar Madhugiri, Amade Bregy, Matthew Recker, Lindsay Lipinski, Andrew Fabiano, Robert Fenstermaker, Robert Plunkett, Ajay Abad, Ahmed Belal, Ronald Alberico, Jingxin Qiu, Dheerendra Prasad
Neurofibromatosis type 1 (NF1) is a tumor predisposition syndrome genetically characterized by mutations in the NF1 tumor suppressor gene and clinically recognized through the development of multiple neurofibromas [ 1 ]. Much scientific progress …
verfasst von:
Archis R. Bhandarkar, Shaan Bhandarkar, Dusica Babovic-Vuksanovic, Aditya Raghunathan, Jonathan Schwartz, Robert J. Spinner
Breast cancer (BC) patients who develop brain metastases (BrM) experience diminished survival following diagnosis, and many experience a rapid decline in quality of life [ 1 ]. In a Surveillance, Epidemiology, and End Results (SEER) database …
verfasst von:
Christopher Poletes, Bardia Amanirad, Anna T. Santiago, Michael Yan, Tatiana Conrad, Katarzyna J. Jerzak, David B. Shultz
Meningiomas account for approximately 35% of primary brain tumors and are typically benign, indolent tumors originating from the arachnoid cells of the dura [ 1 ]. However, 6–8% of meningiomas are atypical or malignant, with recurrence rates of up …
verfasst von:
Michael M. Covell, Joanna M. Roy, Nithin Gupta, Ahmed Sami Raihane, Kranti C. Rumalla, Amanda Cyntia Lima Fonseca Rodrigues, Evan Courville, Christian A. Bowers
Gliomas are the most common primary intracranial tumors, accounting for more than 80% of malignant brain tumors. These tumors are highly diverse, and their prognosis varies widely: overall survival for patients with pilocytic astrocytoma can be …
verfasst von:
Malte Ottenhausen, Mirjam Renovanz, Isabell Bartz, Alicia Poplawski, Darius Kalasauskas, Harald Krenzlin, Naureen Keric, Florian Ringel
5-aminolevulinic acid (5-ALA) is a clinical fluorescence agent first introduced in neurosurgery as an adjuvant tool for malignant glioma resection in 1998 [ 41 ]. It is a natural precursor of hemoglobin in human cells that, when taken orally …
verfasst von:
Erasmo Barros da Silva Jr, Ricardo Ramina, Jorge Luis Novak Filho, Gustavo Simiano Jung, Giulia Xavier Bornancin, Maurício Coelho Neto
Gliomatosis cerebri (GC) is defined as a diffuse glioma that exhibits an infiltrative growth pattern affecting at least three lobes of the brain while grossly maintaining the underlying normal brain architecture [ 1 , 2 ]. Initially recognized as a …
verfasst von:
Ilah Shin, Yongsik Sim, Seo Hee Choi, Yae Won Park, Narae Lee, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Glioblastoma (GBM; World Health Organization (WHO) Grade IV) is the most common and aggressive primary brain tumour in adults, accounting for about 15% of all primary brain tumours and roughly 48% of all malignant gliomas [ 1 , 2 ]. Most cases of …
verfasst von:
Wafa Baqri, Kathryn Rzadki, Steven Habbous, Sunit Das
Neurooncology is a rapidly evolving field, with advances in surgical techniques, radiation therapy, and systemic therapy resulting in improved outcomes for patients with brain tumors. Despite these encouraging strides, the management of malignant …
verfasst von:
Anna Cecilia Lawson McLean, Aaron Lawson McLean, Thomas Ernst, Marie-Therese Forster, Christian Freyschlag, Jens Gempt, Roland Goldbrunner, Stefan Grau, Christine Jungk, Birgitt van Oorschot, Steffen K. Rosahl, Ulrich Wedding, Christian Senft, Marcel A. Kamp, on behalf of the German Consortium for Excellence in Neurooncology, Palliative Care (GCE-NPC)
Brain metastases develop in roughly 10–30% of adult cancer patients, and represent a major cause of morbidity and mortality [ 1 – 3 ]. Stereotactic radiosurgery (SRS) has emerged as the treatment of choice for patients with limited brain metastases …
verfasst von:
Mustafa M. Basree, Chengnan Li, Hyemin Um, Anthony H. Bui, Manlu Liu, Azam Ahmed, Pallavi Tiwari, Alan B. McMillan, Andrew M. Baschnagel
Glioblastoma (GBM), the most common malignant primary brain tumor, is uniformly fatal despite conventional therapy with surgery, radiation, and chemotherapy. One of the difficulties in treating GBM stems from the intrinsic privileged nature of the …
verfasst von:
Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro, Netanel Ben-Shalom, Randy S. D’Amico, Manju Harshan, Amy McKeown, Avraham Zlochower, David J. Langer, John A. Boockvar
