Journal of NeuroVirology OnlineFirst articles

31.05.2024

Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV

Neural damage due to inflammatory activation of macrophages and microglia is a consequence of HIV infection that leads to cognitive dysfunction. The damage is due, in part, to the release of factors that impair neuronal function but the mechanisms …

verfasst von:: Kimberly S. Williams, Jaimie A. Seawell, Viktoriya Zhuravleva, Kersten Pierre, Rick B. Meeker

28.05.2024 | Review

A viral attack on brain tumors: the potential of oncolytic virus therapy

Managing malignant brain tumors remains a significant therapeutic hurdle that necessitates further research to comprehend their treatment potential fully. Oncolytic viruses (OVs) offer many opportunities for predicting and combating tumors through …

verfasst von:: Kasra Mokhtarpour, Milad Akbarzadehmoallemkolaei, Nima Rezaei

22.05.2024 | Case Report

Catastrophic tumefactive acute disseminated encephalomyelitis in patient with dengue virus: a case report

Tumefactive demyelinating lesions (TDL) are a rare occurrence among inflammatory demyelinating diseases of the central nervous system, distinguished by tumor-like lesions exceeding 2 cm in diameter. While various etiologies have been associated …

verfasst von:: Siripong Chayanopparat, Jiraporn Jitprapaikulsan, Tatchaporn Ongphichetmetha

22.05.2024 | Case Report

Spinal cord involvement in progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infectious demyelinating disease of the central nervous system caused by JC polyomavirus predominantly affecting immunocompromised individuals. Nowadays, HIV, hematological …

verfasst von:: Nisrine El Moussaoui, Nicolas Lambert, Majdouline El Moussaoui, Elettra Bianchi, Philippe Léonard, Martin Moïse, Pierre Maquet

Open Access 08.05.2024

Human endogenous retrovirus W in multiple sclerosis: transcriptional activity is associated with decline in oligodendrocyte proportions in the white matter of the brain

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. One of the basic mechanisms in this disease is the autoimmune response against the myelin sheet leading to axonal damage. There is strong evidence showing that this response …

verfasst von:: Tapio Nevalainen, Arttu Autio-Kimura, Mikko Hurme

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Open Access 07.05.2024

Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells

Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmigrating CCR5-using T-cell tropic …

verfasst von:: Stephanie B. H. Gumbs, Arjen J. Stam, Tania Mudrikova, Pauline J. Schipper, Andy I. M. Hoepelman, Petra M. van Ham, Anne L. Borst, LMarije Hofstra, Lavina Gharu, Stephanie van Wyk, Eduan Wilkinson, Lot D. de Witte, Annemarie M. J. Wensing, Monique Nijhuis

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06.05.2024

Cognitive impairment and neurocognitive profiles among people living with HIV and HIV-negative individuals older over 50 years: a comparison of IHDS, MMSE and MoCA

We aimed to examine the l differences in the assessment of neurocognitive impairment (NCI) using cognitive screening tools between PLWH and HIV-negative individuals and further compare the neurocognitive profiles between the two groups. This was …

verfasst von:: Panpan Chen, Xin Xin, Shaotan Xiao, Hantao Liu, Xin Liu, Na He, Yingying Ding

23.04.2024

Neurological aspects of HTLV-1 infection: symptoms in apparently asymptomatic carriers

Human T-lymphotropic virus type 1 (HTLV-1) is classically associated with the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although the mechanisms of this neurological disorder remain unclear. In addition, some patients who …

verfasst von:: Qesya Rodrigues Ferreira, Ana Flávia Novaes, Carolina Souza Santana, Arthur Shigueru Umeda, Jéssica Oliveira de Souza Nascimento, João Pedro Melo de Freitas Santos, Larissa Alves Fernandes, Matheus Nascimento Moura, Rebeca Leão Amorim, Vinícius Nogueira Cavalcanti, Ariana Leal Borges da Cruz, Fernanda Khouri Barreto, Davi Tanajura Costa

Open Access 10.04.2024

Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures

The human immunodeficiency virus (HIV) epidemic is an ongoing global health problem affecting 38 million people worldwide with nearly 1.6 million new infections every year. Despite the advent of combined antiretroviral therapy (cART), a large …

verfasst von:: Martina Donadoni, Senem Cakir, Anna Bellizzi, Michael Swingler, Ilker K. Sariyer

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10.04.2024

Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations

The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets respiratory cells, but emerging evidence shows neurological involvement, with the virus directly affecting neurons …

verfasst von:: Tulika Gupta, Munish Kumar, Ujjwal Jit Kaur, Asha Rao, Ranjana Bharti

Open Access 04.04.2024

Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study

Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is associated with reduced inflammation. We aimed to evaluate neuroinflammation, using translocator protein (TSPO) [11C]PBR28 PET …

verfasst von:: Jasmini Alagaratnam, John P. Thornhill, Zhen Fan, Jaime H. Vera, Jonathan Underwood, Rebecca Hall, Graham Searle, David Owen, Paul Edison, Sarah Fidler, Alan Winston

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03.04.2024

Clinical characteristics and outcomes of COVID-19-associated encephalopathy in children

Apart from the typical respiratory symptoms, coronavirus disease 2019 (COVID-19) also affects the central nervous system, leading to central disorders such as encephalopathy and encephalitis. However, knowledge of pediatric COVID-19-associated …

verfasst von:: Li Li, Hongmei Liao, Xiaojun Kuang, Ke Jin

28.03.2024

Implications of vascular depression for successful cognitive aging in HIV Disease

Although older adults with HIV are at high risk for mild neurocognitive disorders, a subset experience successful cognitive aging (SCA). HIV is associated with an increased risk of vascular depression (VasDep), which can affect cognitive and daily …

verfasst von:: Andrea I. Mustafa, Ilex Beltran-Najera, Darrian Evans, Alexandria Bartlett, Vonetta M. Dotson, Steven Paul Woods

Open Access 19.03.2024 | Case Report

Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging

Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed …

verfasst von:: Hidetada Yamada, Megumi Toko, Masahiro Nakamori, Hiroki Ueno, Shiro Aoki, Tomohiro Sugimoto, Hiroko Yasutomi, Kazuo Nakamichi, Hirofumi Maruyama

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Open Access 13.03.2024

RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection

The neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), playing a crucial role in neurogenesis. However, these NPCs are particularly vulnerable to infection by the herpes simplex …

verfasst von:: Joel A. Wood, Srilakshmi Chaparala, Cecilia Bantang, Ansuman Chattopadhyay, Maribeth A. Wesesky, Paul R. Kinchington, Vishwajit L. Nimgaonkar, David C. Bloom, Leonardo D’Aiuto

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12.03.2024

Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV

Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in actigraphy derived sleep measures in WWH, although may not always correlate with functional impairment. We …

verfasst von:: Eran Frank Shorer, Leah H Rubin, Audrey L French, Kathleen M Weber, Elizabeth Daubert, Tsion Yohannes, Ralph Morack, Clary Clish, Kevin Bullock, Deborah Gustafson, Anjali Sharma, Andrea C Rogando, Qibin Qi, Helen J Burgess, Raha M Dastgheyb

12.03.2024

Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals

We evaluated the diagnostic clinical performance characteristics (DCPC) of cerebrospinal fluid (CSF) total protein (TP), white blood cell count (WBC), and lactate (LA) with different cutoff points as adjunct biomarkers of confirmed or presumptive …

verfasst von:: Sérgio Monteiro de Almeida, José Tresoldi Neto, Amanda Rocha, Ana Medeiros, Debora Gonçalves, Fausto Guimarães

21.02.2024

The synergistic effect of insomnia and depression on risk of herpes zoster

Sleep problems was associated with increased risk for herpes zoster (HZ). This study examined subjects with insomnia or a combination of insomnia and depression and their risk of HZ. This retrospective cohort study included a total of 47,256 …

verfasst von:: Hsueh-Ching Wu, Chia-Ling Lin, Chi-Hsiang Chung, Wu-Chien Chien

23.10.2023 | SI: HTLV-1 Revisited

Immune response to COVID-19 vaccines among people living with human T-cell lymphotropic virus type 1 infection: a retrospective cohort study from Iran

The effectiveness of COVID-19 vaccination is still unclear in individuals with underlying diseases such as HTLV-1 infection. This retrospective cohort study aimed to evaluate the humoral response of COVID-19 vaccines among people living with …

verfasst von:: Reza Jafarzadeh Esfehani, Zohreh Vahidi, Mohammad Shariati, Arman Mosavat, Azam Shafaei, Maryam Shahi, Houshang Rafatpanah, Hamid Reza Bidkhori, Reza Boostani, Mohammad Reza Hedayati-Moghaddam

02.08.2023 | SI: HTLV-1 Revisited

Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo

There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated diseases. Bitter melon (Momordica charantia) is considered a traditional herb with antiviral and anticancer properties and was tested in this study on …

verfasst von:: Sanaz Ahmadi Ghezeldasht, Hamid Reza Bidkhori, Raheleh Miri, Arezoo Baghban, Arman Mosavat, Seyed Abdolrahim Rezaee

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