Journal of Neurology OnlineFirst articles

31.05.2024 | Review

Intelligent devices for assessing essential tremor: a comprehensive review

Essential tremor (ET) stands as the most prevalent movement disorder, characterized by rhythmic and involuntary shaking of body parts. Achieving an accurate and comprehensive assessment of tremor severity is crucial for effectively diagnosing and …

verfasst von:: Yumeng Peng, Chenbin Ma, Mengwei Li, Yunmo Liu, Jinze Yu, Longsheng Pan, Zhengbo Zhang

Open Access 31.05.2024 | Original Communication

Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial

Trigeminal neuralgia (TN) is a common neuropathic pain condition characterized by unilateral, transient, and recurrent episodes of pain confined to one or more branches of the trigeminal nerve [ 1 , 2 ]. Patients with TN often experience stabbing …

verfasst von:: Rongrong Li, Jing Sun, Kaitao Luo, Ning Luo, Ruohan Sun, Feng Gao, Yiyi Wang, Yunfan Xia, Xiaoyu Li, Lifang Chen, Ruijie Ma, Xiaomei Shao, Yi Liang, Jianqiao Fang

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31.05.2024 | Original Communication

Predictors of seizure detection and EEG clinical impact in an italian tertiary emergency department

Epileptic seizures and related neurological disorders pose significant challenges in the emergency department setting, with up to 10% of the admitted patients exhibiting symptoms such as seizures or altered mental status [ 1 – 3 ]. This evidence is …

verfasst von:: Anna Bellini, Davide Gusmeo Curti, Marco Cursi, Giordano Cecchetti, Federica Agosta, Giovanna F. Fanelli, Massimo Filippi

Open Access 31.05.2024 | Original Communication

Motor and non-motor outcome in tremor dominant Parkinson’s disease after MR-guided focused ultrasound thalamotomy

Parkinson’s disease (PD) is characterized clinically by a variety of motor and non-motor symptoms. PD is increasingly considered a heterogeneous syndrome rather than a clear-cut entity, which is evident also with regard to the main clinical …

verfasst von:: Veronika Purrer, Emily Pohl, Valeri Borger, Hannah Weiland, Henning Boecker, Frederic Carsten Schmeel, Ullrich Wüllner

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Open Access 31.05.2024 | Original Communication

Alice in Wonderland Syndrome (AIWS): prevalence and characteristics in adults with migraine

Alice in Wonderland Syndrome (AIWS) is considered [ 1 ] a rare clinical condition, primarily observed in children [ 2 ]. It is marked by a transiently altered visual and/or somatosensory perception of the body or surroundings [ 2 – 5 ], usually …

verfasst von:: Mira P. Fitzek, Jasper Mecklenburg, Lucas H. Overeem, Kristin S. Lange, Anke Siebert, Paul Triller, Lars Neeb, Jens P. Dreier, Daniel Kondziella, Uwe Reuter, Bianca Raffaelli

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30.05.2024 | Review

The various forms of hereditary motor neuron disorders and their historical descriptions

Motor neuron disorders comprise a clinically and pathologically heterogeneous group of neurologic diseases characterized by progressive degeneration of motor neurons (including both sporadic and hereditary diseases), affecting the upper motor …

verfasst von:: Stéphane Mathis, Diane Beauvais, Fanny Duval, Guilhem Solé, Gwendal Le Masson

Open Access 29.05.2024 | Original Communication

Assessing the applicability of the 2023 international MOGAD panel criteria in real-world clinical settings

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined demyelinating disorder affecting the central nervous system, manifesting across all age groups with a broad clinical spectrum encompassing monophasic and …

verfasst von:: Ariel Rechtman, Tal Freidman-Korn, Omri Zveik, Lyne Shweiki, Garrick Hoichman, Adi Vaknin-Dembinsky

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Open Access 29.05.2024 | Original Communication

The multiple roles of nerve biopsy in the diagnosis and prognosis of suspected immune neuropathies

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common treatable autoimmune neuropathy causing progressive or relapsing–remitting weakness and sensory impairment with a prevalence of 0.8–8.9 per 100,000 [ 1 , 2 ]. The …

verfasst von:: Rafael Klimas, Anna Kordes, Sophie Huckemann, Zornitsa Gasz, Jörg Philipps, Melissa Sgodzai, Thomas Grüter, Melis Sevindik, Christiane Schneider-Gold, Ralf Gold, Kathy Keyvani, Min-Suk Yoon, Anna Lena Fisse, Kalliopi Pitarokoili, Jeremias Motte

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Open Access 29.05.2024 | Review

Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review

Dysfunction of the autonomic nervous system is common in people with Parkinson's disease (PD) and includes symptoms of altered cardiovascular, gastrointestinal, urinary, thermoregulatory, and sexual functions. Autonomic dysfunction in PD is an …

verfasst von:: Francescopaolo Cucinotta, Bart Swinnen, Elena Makovac, Stephanie Hirschbichler, Erlick Pereira, Simon Little, Francesca Morgante, Lucia Ricciardi

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28.05.2024 | Original Communication

Parkinson’s disease with hyposmia and dysautonomia: does it represent a distinct subtype?

Parkinson’s disease (PD) is clinically characterized by cardinal motor symptoms of bradykinesia, rigidity, resting tremor, and various nonmotor symptoms. The primary pathological substrate of PD is α-synuclein which forms Lewy bodies and Lewy …

verfasst von:: So Hoon Yoon, Dae Hyuk You, Han Kyu Na, Sungwoo Kang, Kyoungwon Baik, Mincheol Park, Chul Hyoung Lyoo, Young H. Sohn, Phil Hyu Lee

Open Access 28.05.2024 | Original Communication

Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression

Disability accrual in patients with multiple sclerosis (pwMS) can derive from two main mechanisms, relapse-associated worsening (RAW) on the one hand, and progression independent from relapse activity (PIRA) on the other [ 1 , 2 ]. RAW has been …

verfasst von:: Emilio Portaccio, Matteo Betti, Ermelinda De Meo, Ilaria Addazio, Luisa Pastò, Lorenzo Razzolini, Rocco Totaro, Daniele Spitaleri, Alessandra Lugaresi, Eleonora Cocco, Marco Onofrj, Franco Di Palma, Francesco Patti, Davide Maimone, Paola Valentino, Valentina Torri Clerici, Alessandra Protti, Diana Ferraro, Giacomo Lus, Giorgia Teresa Maniscalco, Vincenzo Brescia Morra, Giuseppe Salemi, Franco Granella, Ilaria Pesci, Roberto Bergamaschi, Umberto Aguglia, Marika Vianello, Marta Simone, Vito Lepore, Pietro Iaffaldano, Giancarlo Comi, Massimo Filippi, Maria Trojano, Maria Pia Amato, the Italian Multiple Sclerosis Register

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Open Access 28.05.2024 | Original Communication

Exploratory study to evaluate the acceptability of a wearable accelerometer to assess motor progression in motor neuron disease

Motor neuron disease (MND) is a rapidly progressive condition traditionally assessed using a questionnaire to evaluate physical function, the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). Its use can be associated with …

verfasst von:: Emily Beswick, Alexander Christides, Alexander Symonds, Micheaela Johnson, Thomas Fawcett, Judith Newton, Dawn Lyle, Christine Weaver, Siddharthan Chandran, Suvankar Pal

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Open Access 28.05.2024 | Review

Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of both upper and lower motor neurons. A defining histopathological feature in approximately 97% of all ALS cases is the …

verfasst von:: Bogdan Bjelica, Maj-Britt Bartels, Jasper Hesebeck-Brinckmann, Susanne Petri

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27.05.2024 | Review

Loss of the “swallow tail sign” on susceptibility-weighted imaging in the diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis

Dementia with Lewy bodies (DLB) is one of the most common types of dementia, second only to Alzheimer’s disease (AD) [ 1 , 2 ]. Clinical characteristics of DLB include fluctuating cognitive impairment, visual hallucinations, confusion, rapid-eye …

verfasst von:: Vasilis-Spyridon Tseriotis, Theodoros Mavridis, Kyriaki Eleftheriadou, Georgios Konstantis, David-Dimitris Chlorogiannis, Pavlos Pavlidis, Chryssa Pourzitaki, Marianthi Arnaoutoglou, Konitsiotis Spyridon

27.05.2024 | Correction

Correction to: RFC1‑related disorder presenting recurrent syncope

verfasst von:: Yoko Tsuboyama, Akiko Takahashi, Sawako Furukawa, Asem Almansour, Masashi Hamada, Akatsuki Kubota, Jun Shimizu, Makoto Kinoshita, Chisato Fujimoto, Jun Mitsui, Takashi Matsukawa, Hiroya Naruse, Hiroyuki Ishiura, Shoji Tsuji, Tatsushi Toda

27.05.2024 | Original Communication

Prognostic factors underlying the development of drug-resistant epilepsy in patients with autoimmune encephalitis: a retrospective cohort study

Autoimmune encephalitis (AE) is being increasingly recognized as one of the major causes of acute symptomatic seizures [ 1 ]. According to previous studies, approximately 70% of patients with AE have seizures, and most of them respond well to …

verfasst von:: Wenyao Huang, Heyu Zhang, Xi Li, Jinming Zhang, Jingjing Chen, Ziyi Chen, Guanzhong Ni

Open Access 27.05.2024 | Neurological Update

Update on recent advances in amyotrophic lateral sclerosis

In the last few years, our understanding of disease molecular mechanisms underpinning ALS has advanced greatly, allowing the first steps in translating into clinical practice novel research findings, including gene therapy approaches. Similarly …

verfasst von:: Nilo Riva, Teuta Domi, Laura Pozzi, Christian Lunetta, Paride Schito, Edoardo Gioele Spinelli, Sara Cabras, Enrico Matteoni, Monica Consonni, Eleonora Dalla Bella, Federica Agosta, Massimo Filippi, Andrea Calvo, Angelo Quattrini

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Open Access 27.05.2024 | Original Communication

Recurrent cerebrovascular events after recent small subcortical infarction

Cerebral small vessel disease (SVD) is an important cause of ischaemic stroke as well as intracerebral haemorrhage, and is also associated with the development of vascular dementia, gait disturbance and depression [ 1 , 2 ].

verfasst von:: Melanie Haidegger, Nina Klock, Markus Kneihsl, Simon Fandler-Höfler, Sebastian Eppinger, Kathrin Eller, Stephan Seiler, Christian Enzinger, Thomas Gattringer

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26.05.2024 | Original Communication

Clinical characteristics of cerebral amyloid angiopathy and risk factors of cerebral amyloid angiopathy related intracerebral hemorrhage

Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage (ICH) due to excessive deposition of amyloid β (Aβ) mainly in the cortex and leptomeningeal vessels and subsequent destruction of vascular structure. Its …

verfasst von:: Juanjuan Wu, Ziyue Liu, Ming Yao, Yicheng Zhu, Bin Peng, Jun Ni

26.05.2024 | Letter to the Editors

Senna intoxication as a cause of extrapontine myelinolysis mimicking rapidly progressive dementia: a case description

verfasst von:: Alma Ghirelli, Davide Gusmeo Curti, Sonia Francesca Calloni, Maurizio Barbera, Rosalinda Cardamone, Anna Bellini, Andrea Panzacchi, Arturo Chiti, Andrea Falini, Federica Agosta, Massimo Filippi, Francesca Caso

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