Wiener klinische Wochenschrift OnlineFirst articles

Open Access 31.05.2024 | original article

Is location more determining than WHO grade for long-term clinical outcome in patients with meningioma in the first two decades of life?

Meningiomas in children and adolescents are a poorly understood tumor entity. Data are limited to small case series and meta-analysis. Most authors report the following key features of meningiomas in the first two decades of life: in comparison to …

verfasst von:: Dorian Hirschmann, Danial Nasiri, Christian Joachim Entenmann, Christine Haberler, Thomas Roetzer, Christian Dorfer, Matthias Millesi, MD

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Open Access 24.05.2024 | original article

Socioeconomic equality in initiation of biologic treatment in Danish patients with inflammatory bowel disease

verfasst von:: Sofie Ronja Petersen, MSc, Nathalie Fogh Rasmussen, MSc, Agnete Overgaard Donskov, MD, Lau Caspar Thygesen, PhD, Kim Rose Olsen, PhD, Linda Juel Ahrenfeldt, PhD, Vibeke Andersen, MD PhD

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Open Access 21.05.2024 | short report

Microplastics: Omnipresent and an ongoing challenge for medical science

Micro- and nanoplastics are omnipresent not only in the environment, but have also been detected in human body fluids and tissue. The subsequent commentary provides a perspective about potential risks for human health as well as resulting …

verfasst von:: Hans-Peter Hutter, Lisbeth Weitensfelder, Michael Poteser

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Open Access 16.05.2024 | review article

Emergency critical care: closing the gap between onset of critical illness and intensive care unit admission

Critical illness is an exquisitely time-sensitive condition and follows a disease continuum, which always starts before admission to the intensive care unit (ICU), in the majority of cases even before hospital admission. Reflecting the common …

verfasst von:: PD Dr. Martin W. Dünser, MD DESA EDIC, Matthias Noitz, MD, Thomas Tschoellitsch, MD, Markus Bruckner, MD, Markus Brunner, Bernhard Eichler, MD, Romana Erblich, MD, Stephan Kalb, MD, Marius Knöll, MD, Johannes Szasz, MD, Wilhelm Behringer, MD, Jens Meier, MD

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Open Access 15.05.2024 | original article

Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion

Stroke resulting from large vessel occlusion (LVO) of the proximal middle cerebral artery (MCA) is a devastating disease and a significant contributor to loss of independence [ 1 ]. Endovascular thrombectomy (EVT) as a reperfusion procedure for …

verfasst von:: Katharina Millesi, Monika Killer-Oberpfalzer, Johannes A. R. Pfaff, J. Sebastian Mutzenbach, Christoph J. Griessenauer, Michael Sonnberger, Milan Vosko, Judith Wagner, Matthias Millesi, Slaven Pikija, Constantin Hecker

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15.05.2024 | review article

Neuroprotective and neuroregenerative drugs after severe traumatic brain injury

A narrative review from a clinical perspective

Traumatic brain injuries cause enormous individual and socioeconomic burdens. Survivors frequently struggle with motor handicaps as well as impaired cognition and emotion. In addition to the primary mechanical brain damage, complex secondary …

verfasst von:: Ivan Grgac, Guenther Herzer, Wolfgang G. Voelckel, Julio J. Secades, Prim. Prof. Dr. Helmut Trimmel, MSc

14.05.2024 | original article

Broström ankle ligament repair augmented with suture tape

Results of magnetic resonance imaging evaluation

Despite most patients responding well to conservative treatment after an acute ankle sprain, research suggests an increase of 20–40% in the number of consecutive symptomatic chronic lateral ankle instability (CLAI) that need surgical treatment. So …

verfasst von:: Florian Wenzel-Schwarz, M.D., Ulrike Wittig, M.D., Elena Nemecek, M.D., PhD, Prof. Rudolf Ganger, M.D., P.D., Till Bader, M.D., M.Sc., P.D., Wolfgang Huf, M.D., B.Sc., M.Sc., Reinhard Schuh, M.D., P.D., PhD

14.05.2024 | original article

25 years of lipid-lowering therapy: secular trends in therapy of coronary patients

The most prominent and causal risk factor for cardiovascular events and progression of cardiovascular disease is low-density lipoprotein cholesterol (LDL-C) [ 1 ]. Hence, historical guidelines have consistently advised the regulation of LDL‑C [ 2 …3

verfasst von:: Magdalena Ratz, Johannes B. Vogel, Heike Kührer, Christoph H. Säly, Axel Mündlein, Alexander Vonbank, Arthur Mader, Peter Fraunberger, Andreas Leiherer, Heinz Drexel

Open Access 10.05.2024 | original article

A pilot study evaluating stress factors during and after the COVID-19 pandemic in Viennese families who have the suspicion of child maltreatment or abuse

The global population was affected by the unprecedented coronavirus COVID-19 pandemic. The impact of the pandemic on children who suffer child maltreatment has not been explored sufficiently. Child abuse is known to increase in stressful …

verfasst von:: Dr. Anastasia Pantazidou, MRCPCH, MSc, MD, Dr. Chryssa Grylli, MSc PhD, Mag. Sophie Klomfar, Dr. Eva Mora-Theuer, Dr. Johanna Schöggl, Sarah Macura, BSc MSc, Laura Schaller, BSc, MSc, Iulia Pokorny, BSc, Univ. Prof. Dr. Susanne Greber-Platzer, MBA

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Open Access 07.05.2024 | short report

Treatment of fecal incontinence—is there a light in the end of the tunnel?

Fecal incontinence (FI) is a common disease with higher incidence rates in the elderly population. Treatment of affected patients remains challenging and ranges from conservative management to surgical techniques. Despite all efforts patients …

verfasst von:: Associate Professor Stefan Riss, MD, FRCS, Dr. Christopher Dawoud, MD

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Open Access 07.05.2024 | review article

Gene therapy: principles, challenges and use in clinical practice

Already in 1972, Friedmann and Roblin hypothesized that genetic modification might be the way to cure hereditary diseases [ 1 ]. Following many years of scientific groundwork and technical advancements, the first clinical gene therapy studies …

verfasst von:: Cihan Ay, MD, Andreas Reinisch, MD PhD

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01.05.2024 | review article

The prevalence of presbyphagia in older adults: a systematic review and meta-analysis

Worldwide, populations are aging: from 2020 to 2030 the population of adults aged 60 years or older (older adults) will rise from 1 billion to 1.4 billion and by 2050 the population of adults aged 60 years or older is expected to reach 2.1 billion …

verfasst von:: Jianzheng Cai, Zhina Gong, Yingying Zhang, Haifang Wang, Chunyan Niu, Yinuo Dai

29.04.2024 | historical article

The establishment of orthopedics in Croatia

The role of Božidar Špišić (1879–1957) and his professional networks

Božidar Špišić was a pioneer of Croatian orthopedics. In 1908 he founded the first private orthopedic clinic in the entire South Slav region. During the First World War he organized and headed the first orthopedic hospital for the rehabilitation …

verfasst von:: Stella Fatović-Ferenčić, Martin Kuhar

Open Access 23.04.2024 | original article

External quality assessments for SARS-CoV-2 genome detection in Austria

A comparison of the first postpandemic round with results from the pandemic era

Diagnostic testing for infectious agents is essential to identify symptomatic or asymptomatic infected individuals and is therefore a pillar in the management of epidemics, as recently experienced in the coronavirus disease 2019 (COVID-19) …

verfasst von:: Christoph Buchta, Stephan W. Aberle, Irene Görzer, Andrea Griesmacher, Mathias M. Müller, Erich Neuwirth, Elisabeth Puchhammer-Stöckl, Lukas Weseslindtner, Jeremy V. Camp

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Open Access 23.04.2024 | original article

The Landsteiner lung cancer research platform (LALUCA)

Objectives, methodology and implementation of a real-world clinical lung cancer registry

Lung cancer is the most common cause of cancer-related deaths and the second most frequently diagnosed cancer worldwide [ 1 ]. As in the rest of the world, lung cancer is a major health burden in Austria comprising 19% of all cancer deaths. With …

verfasst von:: Dr. med. Anna Lang-Stöberl, Hannah Fabikan, Maximilian Hochmair, Klaus Kirchbacher, Vania Mikaela Rodriguez, Leyla Ay, Christoph Weinlinger, David Rosenthaler, Oliver Illini, Nino Müser, Georg-Christian Funk, Arschang Valipour

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18.04.2024 | case report

Masqueraded sebaceous gland carcinoma of the lower eyelid in a young pregnant patient

The purpose of this case report is to present misdiagnosed sebaceous gland carcinoma of the lower eyelid with rapid growth in a young woman during pregnancy. Eyelid sebaceous gland carcinoma is a relatively rare tumor and a disease primarily of …

verfasst von:: Karla Randelovic, MD, FEBO, Ivanka Petric Vickovic, MD, PhD, Valentina Lacmanovic Loncar, MD, PhD, Leo Pazanin, MD, PhD, Anita Pusic Sesar, MD, PhD, Renata Ivekovic, MD, PhD, Zoran Vatavuk, MD, PhD

Open Access 18.04.2024 | review article

40 years neonatology

An academic life

Over the last decades neonatology and pediatric intensive care medicine made significant advancements, probably more than most other medical specialties, which have substantially improved the survival rates of preterm infants born at increasingly …

verfasst von:: Univ. Prof. Dr. Arnold Pollak, MD

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17.04.2024 | perspective

Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy

Modern electroconvulsive therapy (ECT) and the approval of nasal esketamine for clinical use have significantly improved the approach to treatment-resistant depression (TRD), which is defined as non-response to at least two different courses of …

verfasst von:: Pia Baldinger-Melich, Marie Spies, Ina Bozic, Siegfried Kasper, Dan Rujescu, Richard Frey

Open Access 08.04.2024 | original article

Impact of age on the transmission of SARS-CoV-2 in healthcare workers

Influence of nonoccupational risk factors

Early in the coronavirus disease 2019 (COVID-19) pandemic (January–May 2020) it was observed that older adults were more vulnerable to infections with a higher incidence [ 1 ], more severe outcomes, and higher case fatality rates [ 2 ] than younger …

verfasst von:: Luis Corral-Gudino, PhD, María Piedad Del-Amo-Merino, MD, Jésica Abadía-Otero, MD, Irene Merino-Velasco, MD, Yolanda Lorenzo-Fernández, MD, Jesús García-Cruces-Méndez, MD, Professor José María Eiros-Bouza, Marta Domínguez-Gil González, PhD

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26.03.2024 | perspective

Perspective: legal, ethical, and medical perspectives of the landscape of assisted suicide in Austria

verfasst von:: Prof. Eva Katharina Masel, MD, PhD, MSc

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