nach oben

Head and Neck Pathology

Erschienen in:

11.01.2022 | Case Reports

Metastatic HPV-Mediated Adenocarcinoma Arising from a Base of Tongue Primary: A Case Report with Cytomorphology and Molecular Findings with Review of the Literature

verfasst von: Stephanie Zheng, Kelly R. Magliocca, Michelle D. Reid, Azeem S. Kaka, Daniel Lubin

Erschienen in: Head and Neck Pathology | Ausgabe 3/2022

Einloggen, um Zugang zu erhalten

Abstract

Human papillomavirus (HPV)-mediated squamous cell carcinomas of the oropharynx are common, however only rare cases of HPV-mediated oropharyngeal adenocarcinoma have been reported to date. In this report, we describe a 50 year old nonsmoking male who originally presented with an enlarging neck mass. Fine needle aspiration cytology confirmed an HPV-mediated adenocarcinoma. Subsequent surgery identified a 0.7 cm base of tongue primary HPV-mediated carcinoma with focal glandular differentiation and a 4.0 cm cystic lymph node metastasis demonstrating entirely glandular differentiation. Next generation sequencing of the metastasis detected a pathogenic NOTCH1 mutation.

Vidal L, Gillison ML. Human papillomavirus in HNSCC: recognition of a distinct disease type. Hematol Oncol Clin N Am. 2008;22:1125–42.CrossRef

Syrjänen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol. 2005;32:59–66.CrossRef

Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM, et al. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. JNCI J Natl Cancer Inst. 1998;90:1626.CrossRef

Jordan RC, Lingen MW, Perez-ordonez B, He X, Pickard R, Koluder M, et al. Validation of methods for oropharyngeal cancer HPV status determination in United States cooperative group trials. Am J Surg Pathol. 2012;36:945–54.CrossRef

Wilczynski SP, Lin BTY, Xie Y, Paz IB. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol. 1998;152:145–56.PubMedPubMedCentral

Cai C, Chernock RD, Pittman ME, El-mofty SK, Thorstad WL, Lewis JS. Keratinizing-type squamous cell carcinoma status and improved survival. Am J Surg Pathol. 2014;38:809–15.CrossRef

Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33:1720–4.CrossRef

Carpenter DH, El-Mofty SK, Lewis JS. Undifferentiated carcinoma of the oropharynx: a human papillomavirus—associated tumor with a favorable prognosis. Mod Pathol. 2011;24:1306–12.CrossRef

Bishop JA, Andreasen S, Hang J, Bullock MJ, Chen TY, Franchi A, et al. HPV-related multiphenotypic sinonasal carcinoma HPV-related carcinoma with adenoid cystic carcinoma-like features. Am J Surg Pathol. 2017;41:1690–701.CrossRef

10.

Bishop JA, Westra WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol. 2011;35:1679–84.CrossRef

11.

Kraft S, Faquin WC, Krane JF. HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior. Am J Surg Pathol. 2012;36:321–30.CrossRef

12.

Bishop JA, Montgomery EA, Westra WH. Use of p40 and p63 immunohistochemistry and human papillomavirus testing as ancillary tools for the recognition of head and neck sarcomatoid carcinoma and its distinction from benign and malignant mesenchymal processes. Am J Surg Pathol. 2014;38:257–64.CrossRef

13.

Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis JS. Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature. Head Neck Pathol. 2011;5:108–16.CrossRef

14.

Chang AMV, Nikiforova MN, Johnson JT, Bauman JE, Perez-Ordonez B, Seethala RR, et al. human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes. Head Neck Pathol. 2014;8:151–6.CrossRef

15.

Hanna J, Reimann JDR, Haddad RI, Krane JF. Human papillomavirus-associated adenocarcinoma of the base of the tongue. Hum Pathol. 2013;44:1516–23. https://doi.org/10.1016/j.humpath.2012.12.004.CrossRefPubMed

16.

Perez-Ordoñez B, Irish JC, Yu ES, Gillison ML. Human papillomavirus-16 associated adenocarcinoma NOS of base of tongue. Head Neck Pathol. 2013;7:268–73.CrossRef

17.

Alexiev BA, Behdad A, Lu X, Cheng E, Samant S. High-risk human papillomavirus-mediated adenocarcinoma of palatine tonsil. Pathol Res Pract. 2020;216:152924. https://doi.org/10.1016/j.prp.2020.152924.CrossRefPubMed

18.

Damato S, Thavaraj S, Winter S, Shah KA. Human papillomavirus-associated adenocarcinoma of the palatine tonsil. Hum Pathol. 2014;45:893–4. https://doi.org/10.1016/j.humpath.2013.09.023.CrossRefPubMed

19.

Stelow EB, Jo VY, Stoler MH, Mills SE. Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol. 2010;34:15–24.CrossRef

20.

Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363:24–35.CrossRef

21.

Hafkamp HC, Manni JJ, Haesevoets A, Voogd AC, Schepers M, Bot FJ, et al. Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer. 2008;122:2656–64.CrossRef

22.

El-Naggar A, Chan J, Grandis J, Takata T, Slootweg P. WHO classification of head and neck tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2017.

23.

Lawrence MS, Sougnez C, Lichtenstein L, Cibulskis K, Lander E, Gabriel SB, et al. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517:576–82.CrossRef

24.

Proweller A, Tu L, Lepore JJ, Cheng L, Lu MM, Seykora J, et al. Impaired notch signaling promotes De novo squamous cell carcinoma formation. Cancer Res. 2006;66:7438–44.CrossRef

25.

Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I, et al. Activation of Notch1 signaling is required for β-catenin—mediated human primary melanoma progression. J Clin Invest. 2005;115:3166–76.CrossRef

26.

Westhoff B, Colaluca IN, D’Ario G, Donzelli M, Tosoni D, Volorio S, et al. Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A. 2009;106:22293–8.CrossRef

27.

Park JT, Chen X, Tropè CG, Davidson B, Shih I-M, Wang T-L. Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am J Pathol. 2010;177:1087–94.CrossRef

28.

Huang J, Song H, Liu B, Yu B, Wang R, Chen L. Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma. J Exp Clin Cancer Res. 2013;32:84.CrossRef

29.

Lubin DJ, Mick R, Shroff SG, Stashek K, Furth EE. The Notch pathway is activated in neoplastic progression in esophageal squamous cell carcinoma. Hum Pathol. 2018;72:66–70. https://doi.org/10.1016/j.humpath.2017.11.004.CrossRefPubMed

30.

Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr Opin Genet Dev. 2007;17:52–9.CrossRef

31.

Shah PA, Huang C, Li Q, Kazi SA, Byers LA, Wang J, et al. NOTCH1 signaling in head and neck squamous cell carcinoma. Cells. 2020;9:1–30.

32.

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333:1157–60.CrossRef

33.

Agrawal N, Frederick MJ, Pickering CR, Chang K, Li RJ, Fakhry C, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333:1154–7.CrossRef

Titel: Metastatic HPV-Mediated Adenocarcinoma Arising from a Base of Tongue Primary: A Case Report with Cytomorphology and Molecular Findings with Review of the Literature
verfasst von: Stephanie Zheng
Kelly R. Magliocca
Michelle D. Reid
Azeem S. Kaka
Daniel Lubin
Publikationsdatum: 11.01.2022
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 3/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01407-4

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Metastatic HPV-Mediated Adenocarcinoma Arising from a Base of Tongue Primary: A Case Report with Cytomorphology and Molecular Findings with Review of the Literature

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2022

Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities?

Whole Exome Sequencing Identifies Somatic Variants in an Oral Composite Hemangioendothelioma Characterized by YAP1-MAML2 Fusion

Squamoglandular Variant of Acinic Cell Carcinoma: A Case Report of a Novel Variant

Changing Trends in Benign Human Papillomavirus (HPV) Related Epithelial Neoplasms of the Oral Cavity: 1995–2015

Role of MDM2, CDK4, BCL2, Parafibromin and Galectin 1 in Differentiating Osteosarcoma from its Benign Fibro-osseous Lesions

Phosphaturic Mesenchymal Tumors in the Head and Neck Demonstrate a Broad Clinical and Morphologic Spectrum

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren