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Lasers in Medical Science

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01.12.2024 | Original Article

Normative retinal nerve fiber layer thickness in a healthy pediatric South Asian cohort: a spectral-domain optical coherence tomography study

verfasst von: Sana Nadeem

Erschienen in: Lasers in Medical Science | Ausgabe 1/2024

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Abstract

Currently, the normative values for retinal nerve fiber layer (RNFL) thickness in our population have not been widely studied. Our study aimed to assess the peripapillary RNFL thickness (RNFLT) with Optopol Copernicus REVO80^® spectral-domain optical coherence tomography (SD-OCT) amongst healthy children and its associations. One hundred eighty-two eyes of 91 consecutive healthy children 3 to 16 years of age with a refractive error ≤ ± 5 D were included after a thorough eye exam including visual acuity, refraction, tonometry, pachymetry, axial length estimation, and slit lamp exam including fundus assessment. RNFLT was measured via Optopol Copernicus REVO80^® high resolution SD-OCT by a single experienced observer with 3D disc mode within a circular area of diameter 3.45 mm and the ring further divided into four quadrants: inferior, superior, nasal, and temporal. The mean age was 11.12 ± 3.12 years (range, 3–16). The average RNFLT was 120.13 ± 12.6 μm. The mean superior RNFL was the thickest at 138.21 ± 16.6 μm, next was the mean inferior RNFLT at 137.62 ± 17.2 μm, followed by the nasal 91.61 ± 18.5 μm and then the temporal at 74.58 ± 11.7 μm. No significant differences in RNFLT were noted between the two eyes. The mean RNFLT was significantly higher in males as compared to females, in vertical quadrants and at an average (p < 0.05). No significant relationship was found between the average RNFLT and factors such as age, axial length, corneal thickness, cup-to-disc ratio, intraocular pressure, or refractive error. This study establishes normative values of RNFLT for this subgroup of Pakistani children for the Optopol Copernicus REVO80^® SD-OCT device.

Günbey C, Konuşkan B (2019) Optic neuropathies in childhood: a review of etiology and treatment. Turk J Pediatr 61(4):471–476. https://doi.org/10.24953/turkjped.2019.04.001CrossRefPubMed

Majander A, Bowman R, Poulton J, Antcliff RJ, Reddy MA, Michaelides M et al (2017) Childhood-onset Leber hereditary optic neuropathy. Br J Ophthalmol 101(11):1505–1509. https://doi.org/10.1136/bjophthalmol-2016-310072CrossRefPubMed

Mole G, Edminson R, Higham A, Hopper C, Hildebrand D (2019) The management of childhood intracranial tumours and the role of the ophthalmologist. Neuroophthalmology 43(6):375–381. https://doi.org/10.1080/01658107.2019.1597130CrossRefPubMedPubMedCentral

Nuijts MA, Imhof SM, Veldhuis N, Dekkers CC, Schouten-van Meeteren AYN, Stegeman I (2021) The diagnostic accuracy and prognostic value of OCT for the evaluation of the visual function in children with a brain tumour: a systematic review. PLoS One 16(12):e0261631. https://doi.org/10.1371/journal.pone.0261631CrossRefPubMedPubMedCentral

Wu JH, Lin CW, Liu CH, Weinreb RN, Welsbie DS (2022) Superior segmental optic nerve hypoplasia: a review. Surv Ophthalmol S0039-6257(22):00036–00034. https://doi.org/10.1016/j.survophthal.2022.02.008CrossRef

Duker JS, Waheed NK, Goldman DR (2014) Introduction to OCT. 1.1 Scanning principles. In: Handbook of Retinal OCT, First edn. Elsevier Saunders, China, p 2

Grzybowski A, Barboni P (2020) OCT and imaging in central nervous system diseases -the eye as a window to the brain, 2nd edn. Springer, Switzerland, pp 196–225CrossRef

Nadeem S (2022) Anterior segment parameters on optical coherence tomography in healthy South Asian children. Photodiagnosis Photodyn Ther. 40:103101. https://doi.org/10.1016/j.pdpdt.2022.103101CrossRefPubMed

Nadeem S (2023) Ganglion cell complex thickness with spectral domain optical coherence tomography and correlations in a normative pediatric South Asian cohort. Microsc Res Tech 86(2):216–222. https://doi.org/10.1002/jemt.24257CrossRefPubMed

10.

Samarawickrama C, Wang JJ, Huynh SC, Pai A, Burlutsky G, Rose KA et al (2010) Ethnic differences in optic nerve head and retinal nerve fibre layer thickness parameters in children. Br J Ophthalmol 94(7):871–876. https://doi.org/10.1136/bjo.2009.158279CrossRefPubMed

11.

Ullah I, Noorani S, Mahsood YJ, Altaf S (2019) Retinal nerve fiber layer thickness in non-glaucomatous Pakistani children. J Postgrad Med Inst 33(3):251–255

12.

Mubashir A, Khan MA, Saeed S, Irfan B, Irfan O, Niazi JH (2018) Mean retinal nerve fiber layer thickness in high myopics using optical coherence tomography in a tertiary care hospital in Karachi. Pakistan. Pak J Ophthalmol 34(1):46–51

13.

Rao A, Sahoo B, Kumar M, Varshney G, Kumar R (2013) Retinal nerve fiber layer thickness in children <18 years by spectral-domain optical coherence tomography. Semin Ophthalmol 28(2):97–102. https://doi.org/10.3109/08820538.2012.760626CrossRefPubMed

14.

Huynh SC, Wang XY, Rochtchina E, Mitchell P (2006) Peripapillary retinal nerve fiber layer thickness in a population of 6-year-old children: findings by optical coherence tomography. Ophthalmology 113(9):1583–1592. https://doi.org/10.1016/j.ophtha.2006.02.067CrossRefPubMed

15.

Salchow DJ, Oleynikov YS, Chiang MF, Kennedy-Salchow SE, Langton K, Tsai JC et al (2006) Retinal nerve fiber layer thickness in normal children measured with optical coherence tomography. Ophthalmology 113(5):786–791. https://doi.org/10.1016/j.ophtha.2006.01.036CrossRefPubMed

16.

Pawar N, Maheshwari D, Ravindran M, Ramakrishnan R (2014) Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography. Indian J Ophthalmol 62(4):412–418. https://doi.org/10.4103/0301-4738.121185CrossRefPubMedPubMedCentral

17.

Zhu BD, Li SM, Li H, Liu LR, Wang Y, Yang Z, Li SY et al (2013) Retinal nerve fiber layer thickness in a population of 12-year-old children in Central China measured by iVue-100 spectral-domain optical coherence tomography: the anyang childhood eye study. Invest Ophthalmol Vis Sci 54(13):8104–8111. https://doi.org/10.1167/iovs.13-11958CrossRefPubMed

18.

Yao Y, Fu J, Li L, Chen W, Meng Z, Su H, Dai W (2021) Retinal and circumpapillary nerve fiber layer thickness and associated factors in children. Eye (Lond) 35(10):2802–2811. https://doi.org/10.1038/s41433-020-01313-zCrossRefPubMed

19.

Wang CY, Zheng YF, Liu B, Meng ZW, Hong F, Wang XX et al (2018) Retinal nerve fiber layer thickness in children: the Gobi Desert children eye study. Invest Ophthalmol Vis Sci 59(12):5285–5291. https://doi.org/10.1167/iovs.18-25418CrossRefPubMed

20.

Ayala M, Ntoula E (2016) Retinal fibre layer thickness measurement in normal paediatric population in Sweden using optical coherence tomography. J Ophthalmol 4160568. https://doi.org/10.1155/2016/4160568

21.

Zhang XJ, Lau YH, Wang YM, Chan HN, Chan PP, Kam KW et al (2022) Thicker retinal nerve fiber layer with age among schoolchildren: the Hong Kong children eye study. Diagnostics (Basel) 12(2):500. https://doi.org/10.3390/diagnostics12020500CrossRefPubMed

22.

Lee JWY, Yau GSK, Woo TTY, Yick DWF, Tam VTY, Lai JSM (2015) Retinal nerve fiber layer thickness in myopic, emmetropic, and hyperopic children. Medicine (Baltimore) 94(12):e699. https://doi.org/10.1097/MD.0000000000000699CrossRefPubMed

23.

Hua Z, Fang Q, Sha X, Yang R, Hong Z (2015) Role of retinal nerve fiber layer thickness and optic disk measurement by OCT on early diagnosis of glaucoma. Eye Sci 30(1):7–12PubMed

24.

Runge AK, Remlinger J, Abegg M et al (2022) Retinal layer segmentation in a cohort of healthy children via optical coherence tomography. PLoS One 17(11):e0276958. https://doi.org/10.1371/journal.pone.0276958CrossRefPubMedPubMedCentral

25.

Al-Mujaini AS, Al-Mujaini MS, Sabt BI (2021) Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman. BMC Ophthalmol 21(1):391. https://doi.org/10.1186/s12886-021-02158-0CrossRefPubMedPubMedCentral

26.

Cettomai D, Hiremath G, Ratchford J, Venkatesan A, Greenberg BM, McGready J et al (2010) Associations between retinal nerve fiber layer abnormalities and optic nerve examination. Neurology 75(15):1318–1325. https://doi.org/10.1212/WNL.0b013e3181f735bdCrossRefPubMedPubMedCentral

27.

Mukherjee C, Al-Fahad Q, Elsherbiny S (2019) The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review. Ther Adv Ophthalmol 11:2515841419831155. https://doi.org/10.1177/2515841419831155CrossRefPubMedPubMedCentral

28.

Krumova S, Sivkova N, Marinov V, Koleva-Georgieva D, Voynikova D (2020) Normal reference ranges of optical coherence tomography parameters in children. Folia Med (Plovdiv) 62(2):338–344. https://doi.org/10.3897/folmed.62.e46678CrossRefPubMed

29.

Nemeș-Drăgan IA, Drăgan AM, Hapca MC, Oaida M (2023) Retinal nerve fiber layer imaging with two different spectral domain optical coherence tomographs: normative data for Romanian children. Diagnostics (Basel) 13(8):1377. https://doi.org/10.3390/diagnostics13081377CrossRefPubMed

Titel: Normative retinal nerve fiber layer thickness in a healthy pediatric South Asian cohort: a spectral-domain optical coherence tomography study
verfasst von: Sana Nadeem
Publikationsdatum: 01.12.2024
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2024
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-03971-x

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Normative retinal nerve fiber layer thickness in a healthy pediatric South Asian cohort: a spectral-domain optical coherence tomography study

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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