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Sleep and Breathing

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29.07.2022 | Sleep Breathing Physiology and Disorders • Review

Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis

verfasst von: Huihui Wang, Jiyuan Lu, Lingdan Xu, Yanduo Yang, Yucheng Meng, Yi Li, Bin Liu

Erschienen in: Sleep and Breathing | Ausgabe 3/2023

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Abstract

Purpose

Testosterone deficiency (TD) negatively affects male sexuality, reproduction, general health, and quality of life. In recent years, decreased serum testosterone levels have been reported to be caused by obstructive sleep apnea (OSA). However, these results are controversial and lack the support of a large number of high-quality studies. Hence, we performed a meta-analysis to assess the association between OSA and serum testosterone levels.

Methods

To identify eligible studies, we conducted a systematic retrieval in the electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE) from their inception to September 2021. We chose studies with definitive diagnoses of OSA, including effects of OSA on testosterone level. Random effect model was used for analysis.

Results

This meta-analysis included 24 case–control studies with 1389 patients (1268 male patients) and 845 controls (745 male control). The serum testosterone levels in the male OSA group were significantly lower than that of control group [SMD = − 0.97, 95% CI (− 1.47, − 0.47)], while there was no difference in female patients with OSA and control [SMD = 0.06, 95% CI (− 0.22, 0.33)]. Subgroup analysis showed that race, age, body mass index (BMI), and detection method were the reason for high heterogeneity (I² = 94.9%).

Conclusions

The results indicated that OSA is significantly correlated with the decrease in serum testosterone levels in men. Male patients with OSA should be alerted to secondary diseases caused by low testosterone levels.

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Titel: Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis
verfasst von: Huihui Wang
Jiyuan Lu
Lingdan Xu
Yanduo Yang
Yucheng Meng
Yi Li
Bin Liu
Publikationsdatum: 29.07.2022
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-022-02655-6

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Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis