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01.01.2024 | Research

Optical clearing agents based on metallic and dielectric nanoparticles for caries diagnostic by optical coherence tomography

verfasst von: Vanda Sanderana Macedo Carneiro, Eloiza Leonardo de Melo, Claudia Cristina Brainer de Oliveira Mota, Evair Josino da Silva, Andréa Ferreira da Silva, Nathalia Seimi Deama, Jéssica Meirinhos Miranda, Suzanne Ivila Santos da Rocha, Caio de Lima Pires, Anderson Stevens Leonidas Gomes, Marleny Elizabeth Márquez de Martínez Gerbi

Erschienen in: Clinical Oral Investigations | Ausgabe 1/2024

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Abstract

Objective

This study aimed to assess the effect of titanium dioxide (TiO₂) and silver (Ag) nanoparticles dispersed in glycerol or water, serving as optical clearing agents nanocolloids (OCAs-NC), for improving optical coherence tomography (OCT) images and highlighting incipient lesions in ex vivo human teeth.

Materials and methods

Twelve human teeth with incipient lesions were divided into seven groups according to the OCA-NC; they were subjected to G1 (air), G2 (glycerol), G3 (TiO₂ 0.1%), G4 (TiO₂ 0.01%), G5 (TiO₂ 0.001%), G6 (AgNO₃ 10%), and G7 (AgNO₃ 100%). The OCA-NC was applied to the occlusal surface, and two-dimensional images of the specimens were analyzed using OCT (930 nm central wavelength; 100 nm bandwidth; 5 mW output power; axial resolution of 7/5.3 μm in water and air, respectively; lateral resolution of 8 μm; and light penetration depth of 1.6 mm inside the sample).

Results

The findings demonstrated that the utilization of OCAs-NC containing metallic or dielectric nanoparticles (AgNO₃ and TiO₂) led to improved differentiation between sound and demineralized enamel on occlusal surfaces. Additionally, it enhanced the depth of image penetration when analyzing this hard tissue with OCT.

Clinical relevance

In the current context of minimally invasive dentistry, the use of OCAs-NC in conjunction with OCT can provide clinicians with early diagnosis, allowing for the determination of less/more invasive therapies and consequently halting the disease before cavitation of dental tissues occurs.

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Titel: Optical clearing agents based on metallic and dielectric nanoparticles for caries diagnostic by optical coherence tomography
verfasst von: Vanda Sanderana Macedo Carneiro
Eloiza Leonardo de Melo
Claudia Cristina Brainer de Oliveira Mota
Evair Josino da Silva
Andréa Ferreira da Silva
Nathalia Seimi Deama
Jéssica Meirinhos Miranda
Suzanne Ivila Santos da Rocha
Caio de Lima Pires
Anderson Stevens Leonidas Gomes
Marleny Elizabeth Márquez de Martínez Gerbi
Publikationsdatum: 01.01.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 1/2024
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05473-6

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Optical clearing agents based on metallic and dielectric nanoparticles for caries diagnostic by optical coherence tomography