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03.01.2022 | Epidemiology • Original Article

Peripheral blood oxidative stress markers for obstructive sleep apnea—a meta-analysis

verfasst von: Yuzhui Hu, Lin Mai, Jingying Luo, Wensong Shi, Hui Xiang, Sijia Song, Liuyan Hong, Wenting Long, Biwen Mo, Miao Luo

Erschienen in: Sleep and Breathing | Ausgabe 4/2022

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Abstract

Objectives

The purpose of this study was to clarify the relationship between obstructive sleep apnea (OSA) and oxidative stress markers in blood.

Methods

We conducted a systematic literature search on databases including Pubmed and Embase for studies reporting circulating oxidative stress markers in patients with OSA and controls that were published between 1988 and June 2019. Standardized mean differences (SMDs) and 95% confidence intervals (95%CI) were calculated.

Results

Of the 2226 articles initially retrieved, 52 were included in our meta-analysis, covering a total of 12 oxidative stress markers. The concentrations of malondialdehyde (SMD = 1.18; 95%CI: 0.87, 1.49; p < 0.001), thiobarbituric acid reactive substances (SMD = 1.82; 95%CI: 0.79, 2.86; p = 0.001), advance oxidative protein products (SMD = 0.68; 95%CI: 0.14, 1.23; p = 0.014), total oxidant capacity (SMD = 1.32; 95%CI: 0.33, 2.31; p = 0.009), and asymmetric dimethylarginine (SMD = 0.32; 95%CI: 0.16, 0.47; p < 0.001) in the blood of patients with OSA were higher than those of the control group, whereas the concentrations of thiols (SMD = − 0.37; 95%CI: − 0.60, − 0.15; p = 0.001) and nitric oxide (SMD = − 2.61; 95%CI: − 4.02, − 1.21; p < 0.001) were lower than those of the control group.

Conclusions

The oxidative stress markers in the blood of patients with OSA were aberrant, indicating an imbalanced state of oxidation and antioxidation in OSA.

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Titel: Peripheral blood oxidative stress markers for obstructive sleep apnea—a meta-analysis
verfasst von: Yuzhui Hu
Lin Mai
Jingying Luo
Wensong Shi
Hui Xiang
Sijia Song
Liuyan Hong
Wenting Long
Biwen Mo
Miao Luo
Publikationsdatum: 03.01.2022
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02557-z

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Peripheral blood oxidative stress markers for obstructive sleep apnea—a meta-analysis