Introduction
Methods
Exclusion criteria were single case reports, studies published in languages other than English, and studies of multiple tumour types where data specific to prolactinomas could not be extracted. The references of identified studies, as well as relevant textbooks, were consulted to identify additional eligible studies.(Prolactinoma (MP) OR Lactotroph OR Hyperprolactinaemia OR Hyperprolactinemia) AND (quality of life OR wellbeing OR QOL).
Results
Author (Year) | N (Active vs. Controlled disease at start of study) | QoL Metric | Comparison | Design | Outcome |
---|---|---|---|---|---|
Andela (2016) | 92 (0/92) | EQ-5D, SF36, MFI-20, HADS, LBNQ-Pituitary | Other pituitary adenomas | Cross sectional | Prolactinoma had less physical and cognitive complaints, social functioning issues, than CD No difference compared to other adenomas |
Athanasoulia (2012) | 86 (NR) | EPQ, TPQ | NFPA (n = 58), healthy controls (n = 172) | Cross sectional | Prolactinoma had increased neuroticism, fear of uncertainty, fatigability and asthenia compared to healthy controls Prolactinoma demonstrated reduced extraversion and increased shyness with strangers compared to NFPA |
Baird (2003) | 22 (NR) | SIP | Other adenoma types | Cross sectional | Prolactinomas had less impairment than other pituitary tumours, but the characteristics of the impairments were similar |
Buckman (1985) | 10 (10/0) | BDI, KDS, HRDS | bromocriptine vs. placebo | 6 week double bind crossover trial | Depression, anxiety, wellbeing and friendliness scores improved with bromocriptine and approached values seen in healthy controls Global scores of wellbeing and libido improved with bromocriptine. |
Castle-Kirszbaum (2022) | 18 (18/0) | ABSQ, SNOT-22 | Other pituitary adenomas | Prospective cohort with 12 month follow-up | QOL increased from baseline levels by 3mo postop and continued to improve at 6mo and 12mo Prolactinoma increased in QOL more than other adenoma types |
Cesar de Oliveira Naliato (2008) | 50 (25/25) | SF-36 | Healthy controls | Cross sectional | QoL scores worse in all SF-36 components compared to controls No difference in scores between cabergoline and bromocriptine Patients with normalised prolactin had better scores than patients with persistent hyperprolactinaemia in all components General health, social functioning, and mental health were all worse in patients with normalised prolactin compared to controls Amenorrhoea was not associated with SF-36 scores SF-36 Physical role, pain and mental health scores correlated with PRL levels |
Ernernsson (2023) | 32 (NR) | FIS, ESS, SF-36 | Normative data | Cross sectional | QoL scores worse in all SF-36 components compared to controls. 37.5% had day-time sleepiness (ESS > 10) |
Heald (2004) | 24 (NR) | HADS, WHO-QoL, GHQ, FACT, SAS | Other adenoma types | Cross sectional | |
Johnson (2003) | 39 (NR) | SF-36 | Other adenoma types Healthy controls | Cross sectional | Mental health scores, and vitality lower in prolactinoma compared to controls More impairment in mental than physical aspects of QOL |
Kars (2007) | 55 (18/37) | SF-36, NHP, MFI-20, HADS | Healthy controls | Cross sectional | Anxiety and depression (HADS) and fatigue (MFI-20) worse with prolactinoma Social functioning and role limitations due to physical problems of the SF-36 Energy, emotional reaction, and social isolation subscales of the NHP worse in prolactinoma |
Leistner (2015) | 74 (24/50) | PSQI, Euro-QoL, BDI | Healthy controls Other pituitary adenomas | Cross sectional | Cushing’s patients had worse QOL and depression scores than prolactinomas |
Lobatto (2019) | 16 (16/0) | Euro-QoL, SF-36, LBNQ-Pituitary, VFQ-25, SNOT-22, ASK-12, HLQ | Other pituitary adenomas | Prospective cohort with 6 month follow-up | After surgery: 81% improved in LBNQ-Pituitary score as early as 5d post-op Clinically significant improvement in SF-36 mental in 56%, and 37.5% in physical. Mental SF-36 improved within 6w 50% clinically significant improvement in EQ-index after 6mo Sinonasal morbidity was at baseline by 6w after surgery |
Raappana (2012) | 17 (6/11) | 15D | Healthy controls | Cross sectional | Prolactinoma with DA treatment had a lower sexual activity scoresw Worse scores in sleep mental health, sex life, vitality, and distress in prolactinoma compared to control |
Reavley (1997) | 65 (65/0) | HADS, SCL90 | NFPA and acromegaly | Cross sectional | 54% had definite or borderline anxiety Similar rates of depression, higher rates of hostility in prolactinoma |
Ritvonen (2014) | 26 (4/22) | 15D | Other adenoma types Healthy controls | Cross sectional | Scores similar to controls |
Van der Klaauw (2008) | 128 (NR) | SF-36, NHP, MFI-20, HADS | Other adenoma types Healthy controls | Cross sectional | PRL scores worse in all scales cf. controls (mean 0.7 SD above control) QoL parameters did not differ between microadenomas and macroadenomas and those on DA and not |
van der Meulen (2021) | 116 (38/78) | LBNQ-Pitutiary, SF-36, Euro-QoL | nil | Cross sectional | Association between higher healthcare utilisation, worse QOL scores and higher prolactin levels |
Vega-Beyhart 2019 | 53 (28/25) | SF-36 | Healthy controls | Cross sectional | Persistent hyperprolactinaemia had worse SF-36 scores than those with biochemically controlled disease Prolactin levels varied inversely with Mental and physical SF-36 cores Mental scores were lower in patients with hyperprolactinemia, VF deficits, and macroadenomas Physical scores were lower in patients with hyperprolactinemia, VF deficits, and central adrenal insufficiency |