07.05.2024 | REVIEW PAPER
Serum Biomarkers in Fascial Space Infections of Odontogenic Origin and Their Role in Prognosis of Sepsis: A Systematic Review
verfasst von:
Neethu Kumaran Geetha, Indulakshmi Nair, Amal Suraj, A. M. Arunkumar
Erschienen in:
Journal of Maxillofacial and Oral Surgery
Einloggen, um Zugang zu erhalten
Abstract
Odontogenic infections represent a frequent cause of dental and maxillo facial interventions, mostly due to late presentations or misdiagnosed complications. It is believed that the intensity of the immune inflammatory response is the main prognostic factor. The early detection of systemic sepsis conditions from odontogenic infections can be facilitated using serum biomarkers such as total WBC count, serum c reactive protein, procalcitonin (PCT), presepsin (PSEP), neutrophil lymphocyte ratio and mid-regional adrenomedullin. A total of 15 articles were analyzed to investigate the use of these biomarker in infections and including only English-language articles and the electronic search of publications including google scholar, pubmed from January 2013 to January 2023. This systematic analysis aimed to determine the diagnostic value of different biomarkers in early detection of sepsis derived from an odontogenic infection and to evaluate its use in the prognostic evaluation. The diagnostic value of procalcitonin (PCT) and presepsin (PSEP), mid-regionioal adrenomedullin and neutrophil–lymphocyte ratio is highly sensitive and can be used as potential severity predictors in patients with odontogenic infections as well as can be used for assessment of recovery of these patients.