Erschienen in:
09.04.2022 | Original Article
Significance of bisphosphonates on angiogenesis in vivo and their effect under geranyl-geraniol addition — could it alter the treatment of bisphosphonate-associated necrosis of the jaw?
verfasst von:
Marius Otto, Julia Weigel, Thomas Ziebart, Juliana Lemound
Erschienen in:
Oral and Maxillofacial Surgery
|
Ausgabe 2/2023
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Abstract
Purpose
The aim of this study was to contribute to the understanding of the inhibitory effects of bisphosphonates on tissues, with a special focus on angiogenesis. Referring to bisphosphonate-associated osteonecrosis of the jaw (BP-ONJ), it should be shown that the local addition of the isoprenoid geranyl-geraniol (GGOH) prevents vascularization processes.
Methods
A mouse model with n = 24 animals which received an injection of a collagen matrix was used. In 4 subgroups (n = 6), we examined the effect of zoledronate on the sprouting of capillary-like structures into the matrix, with and without the presence of geranyl-geraniol, as well as testing against control groups with PBS injections or collagen matrix containing PBS instead of GGOH. This was followed by a histological evaluation of the capillary-like structures.
Results
Zoledronate inhibits the sprouting of blood vessels into a collagen matrix in vivo; in the presence of GGOH this effect is significantly weakened by a factor of 3.9 (p = 0.00068).
Conclusion
This work commits to the investigation of the pathophysiology of BP-ONJ and shows a possible causal therapeutic path via the topical application of GGOH.