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18.04.2023 | Neurology • Original Article

Sleep in multiple sclerosis and neuromyelitis optica spectrum disorder—the SEMN study

verfasst von: Nise Alessandra Carvalho Sousa, Carlos Mauricio Oliveira de Almeida, Satiko Andrezza Ferreira Takano, Siane Prado Lima Souza, Ronaldo Marques Pontes Rabelo

Erschienen in: Sleep and Breathing | Ausgabe 6/2023

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Abstract

Purpose

This study aimed to (1) evaluate in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) the presence of sleep disorders such as hypersomnia, fatigue, risk of apnea, and the presence of restless legs syndrome/Willis-Ekbom disease (RLS/WED); (2) evaluate quality of sleep in patients with MS and NMOSD; and (3) correlate them with clinical and imaging data.

Methods

The study was cross-sectional and was carried out in the sector of demyelinating diseases of the neurology service of HUGV-UFAM, Manaus, Brazil, from January 2017 to December 2020.

Results

Our sample consisted of 60 patients, 41 with MS and 19 with NMOSD. We found that patients with MS and NMOSD have poor sleep quality (65%) and hypersomnia (53% in MS; 47% in NMOSD), but low risk of apnea by STOP-BANG. The frequency of RLS/WE found was 14% in MS, and 5% in NMOSD. No correlation existed between sleep quality, number of relapses, and sleep quality for the Expanded Disability Status Scale (EDSS), i.e., fatigue/illness duration.

Conclusion

Patients with MS and NMOSD have poor sleep quality, excessive sleepiness, and are at low risk for OSA, yet the frequency of RLS/WED is like that of the general population. There does not seem to be a significant difference between these sleep disorders in these demyelinating diseases of the CNS.

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Titel: Sleep in multiple sclerosis and neuromyelitis optica spectrum disorder—the SEMN study
verfasst von: Nise Alessandra Carvalho Sousa
Carlos Mauricio Oliveira de Almeida
Satiko Andrezza Ferreira Takano
Siane Prado Lima Souza
Ronaldo Marques Pontes Rabelo
Publikationsdatum: 18.04.2023
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 6/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-023-02824-1

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Sleep in multiple sclerosis and neuromyelitis optica spectrum disorder—the SEMN study