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Erschienen in:
01.12.2024 | Reviews
The effectiveness of low level laser therapy and ibuprofen in the management of pain during orthodontics treatments: a meta-analysis of meta-analyses
Erschienen in: Lasers in Dental Science | Ausgabe 1/2024
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Purpose
Orthodontics treatments (OT) cause temporary inflammatory response and consequently pain. Several meta-analyses have been conducted to address the effects of pharmacological and non-pharmacological approaches on pain management, however, the results are contradictory. Thus, present meta-analysis of meta-analyses was conducted to provide a definite conclusion on the efficacy of pharmacological and non-pharmacological approaches in pain management after OT.
Methods
Web of Science, PubMed, Scopus, Cochrane Central Library, and EMBASE were searched up to June 2023. All meta-analysis of controlled trials investigating the effect of ibuprofen and low level laser therapy (LLLT) on pain under OTs were included. General characteristics of the studies, effect sizes and confidence intervals were extracted. Random-effects model was used to estimate the pooled results. Subgroup and sensitivity analyses were also conducted. AMSTAR2 was used for quality assessment.
Results
Overall, 11 studies were included in this umbrella review among which 9 studies went under quantitative assessment. The results of six meta-analyses with 33 effect sizes indicated that LLLT was efficacious in reducing pain after OT (ES = − 3.52; 95% CI: -4.20, − 2.83, p = 0.20) (I2 = 95.9%, p ≤ 0.001). Also, pooled analysis of 4 meta-analyses with 40 effect sizes showed that Ibuprofen significantly reduced pain after OT (ES = − 0.19; 95% CI: − 0.20, − 0.08, p ≤ 0.001) (I2 = 64.5%, p ≤ 0.001).
Conclusion
The results support the use of LLLT and ibuprofen for the management of the pain after OT.