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Lasers in Medical Science

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01.12.2023 | Review Article

The efficacy of CO₂ laser in the treatment of genitourinary syndrome of menopause: a systematic review and meta-analysis of randomized controlled trials

verfasst von: Qiancheng Mao, Tong Cai, Haijuan Li, Yongli Chu, Yuanshan Cui, Jitao Wu

Erschienen in: Lasers in Medical Science | Ausgabe 1/2023

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Abstract

CO₂ laser has been proposed as a treatment strategy for genitourinary syndrome of menopause (GSM). In order to assess its efficacy for treating GSM, we conducted a systematic review and meta-analysis. To identify the current state of randomized controlled trials on CO₂ laser therapy for GSM, a literature review was conducted. We systematically searched the following databases: PUBMED, EMBASE and the Cochrane Controlled Trials Register. In addition, a review of the references in the retrieved studies was carried out. Of 562 identified studies, 9 were eligible and were included in our analysis, involving 523 patients in total. Based on our analysis, CO₂ laser has no statistical difference compared with estrogen in VHI (p = 0.87), FSFI total score (p = 0.19), FSFI-Arousal (p = 0.11), FSFI-Desire (p = 0.72), FSFI-Orgasm (p = 0.45) and FSFI-Satisfaction (p = 0.08). The meta-analysis also showed that CO₂ laser significantly improved FSFI-Lubrication scores compared with estrogen therapy (p = 0.0004). Furthermore, compared with the sham group, CO₂ laser group had statistically improved VHI scores (p = 0.003) and FSFI scores (p < 0.00001). CO₂ laser therapy may be an effective alternative to estrogen therapy for GSM both in cases where estrogen is not applicable because of comorbidities and in cases in which women do not desire to take estrogen.

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Titel: The efficacy of CO2 laser in the treatment of genitourinary syndrome of menopause: a systematic review and meta-analysis of randomized controlled trials
verfasst von: Qiancheng Mao
Tong Cai
Haijuan Li
Yongli Chu
Yuanshan Cui
Jitao Wu
Publikationsdatum: 01.12.2023
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2023
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-023-03808-z

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

The efficacy of CO₂ laser in the treatment of genitourinary syndrome of menopause: a systematic review and meta-analysis of randomized controlled trials

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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