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Erschienen in: Current Pain and Headache Reports 4/2024

12.02.2024 | Chronic Pain Medicine (O Viswanath, Section Editor)

The Gut Microbiota and Chronic Pain

verfasst von: Ray Pak, Michelle Cho, Keth Pride, Alaa Abd-Elsayed

Erschienen in: Current Pain and Headache Reports | Ausgabe 4/2024

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Abstract

Purpose of Review

To examine the effects and interactions between gut microbia and chronic pain.

Recent Findings

The gut microbiome has been an area of interest in both the scientific and general audience due to a growing body of evidence suggesting its influence in a variety of health and disease states. Communication between the central nervous system (CNS) and gut microbiome is said to be bidirectional, in what is referred to as the gut-brain axis.

Summary

Chronic pain is a prevalent costly personal and public health burden and so, there is a vested interest in devising safe and efficacious treatments. Numerous studies, many of which are animal studies, have been conducted to examine the gut microbiome’s role in the pathophysiology of chronic pain states, such as neuropathy, inflammation, visceral pain, etc. As the understanding of this relationship grows, so does the potential for therapeutic targeting of the gut microbiome in chronic pain.
Literatur
3.
Zurück zum Zitat Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas). 2018;17(4):28–32. PMID: 31043907; PMCID: PMC6469458.PubMed Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas). 2018;17(4):28–32. PMID: 31043907; PMCID: PMC6469458.PubMed
9.
Zurück zum Zitat Institute of Medicine (US) Committee on Pain, Disability, and Chronic Illness Behavior, Osterweis M, Kleinman A, Mechanic D. Pain and disability: clinical, behavioral, and public policy perspectives. Washington DC: National Academies Press US; 1987. p. 7. Available from https://www.ncbi.nlm.nih.gov/books/NBK219252/. Institute of Medicine (US) Committee on Pain, Disability, and Chronic Illness Behavior, Osterweis M, Kleinman A, Mechanic D. Pain and disability: clinical, behavioral, and public policy perspectives. Washington DC: National Academies Press US; 1987. p. 7. Available from https://​www.​ncbi.​nlm.​nih.​gov/​books/​NBK219252/​.
18.
Zurück zum Zitat Janssens Y, Wynendaele E, Verbeke F, Debunne N, Gevaert B, Audenaert K, De Spiegeleer B, et al. Screening of quorum sensing peptides for biological effects in neuronal cells. Peptides. 2018;101:150–6.CrossRefPubMed Janssens Y, Wynendaele E, Verbeke F, Debunne N, Gevaert B, Audenaert K, De Spiegeleer B, et al. Screening of quorum sensing peptides for biological effects in neuronal cells. Peptides. 2018;101:150–6.CrossRefPubMed
22.
23.
Zurück zum Zitat Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology. 1990;99:1688–704.CrossRefPubMed Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology. 1990;99:1688–704.CrossRefPubMed
24.
Zurück zum Zitat •• Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, et al. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013;501:52–7. Good article providing understanding of the topic.ADSCrossRefPubMedPubMedCentral •• Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, et al. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013;501:52–7. Good article providing understanding of the topic.ADSCrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia. 1998;23(1):75–83 PMID: 9562186.CrossRefPubMed Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia. 1998;23(1):75–83 PMID: 9562186.CrossRefPubMed
33.
35.
Zurück zum Zitat Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol. 2003;521:1–21 PMID: 12617561.PubMed Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol. 2003;521:1–21 PMID: 12617561.PubMed
46.
Zurück zum Zitat Moloney RD, Johnson AC, O’Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF. Stress and the microbiota-gut-brain axis in visceral pain: relevance to irritable bowel syndrome. CNS Neurosci Ther. 2016;22(2):102–17. https://doi.org/10.1111/cns.12490. Epub 2015 Dec 10. PMID: 26662472; PMCID: PMC6492884.CrossRefPubMed Moloney RD, Johnson AC, O’Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF. Stress and the microbiota-gut-brain axis in visceral pain: relevance to irritable bowel syndrome. CNS Neurosci Ther. 2016;22(2):102–17. https://​doi.​org/​10.​1111/​cns.​12490. Epub 2015 Dec 10. PMID: 26662472; PMCID: PMC6492884.CrossRefPubMed
51.
Zurück zum Zitat Si JM, Yu YC, Fan YJ, Chen SJ. Intestinal microecology and quality of life in irritable bowel syndrome patients. World J Gastroenterol. 2004 Jun 15;10(12):1802–5. Si JM, Yu YC, Fan YJ, Chen SJ. Intestinal microecology and quality of life in irritable bowel syndrome patients. World J Gastroenterol. 2004 Jun 15;10(12):1802–5.
52.
Zurück zum Zitat Rajilić-Stojanović M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology. 2011;141:1792–801. Rajilić-Stojanović M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology. 2011;141:1792–801.
63.
Zurück zum Zitat Urita Y, Goto M, Watanabe T, Matsuzaki M, Gomi A, Kano M, et al. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders. Biosci Microbiota Food Health. 2015;34(2):37–44. https://doi.org/10.12938/bmfh.2014-017. Epub 2015 Jan 21. PMID: 25918671; PMCID: PMC4405396.CrossRefPubMedPubMedCentral Urita Y, Goto M, Watanabe T, Matsuzaki M, Gomi A, Kano M, et al. Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders. Biosci Microbiota Food Health. 2015;34(2):37–44. https://​doi.​org/​10.​12938/​bmfh.​2014-017. Epub 2015 Jan 21. PMID: 25918671; PMCID: PMC4405396.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5(7):658–66. https://doi.org/10.1016/S2468-1253(20)30056-X. Epub 2020 Apr 8. PMID: 32277872.CrossRefPubMed Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5(7):658–66. https://​doi.​org/​10.​1016/​S2468-1253(20)30056-X. Epub 2020 Apr 8. PMID: 32277872.CrossRefPubMed
70.
76.
Zurück zum Zitat Liebregts T, Adam B, Bertel A, Jones S, Schulze J. Effect of E. coli Nissle, 1917 on post-inflammatory visceral sensory function in a rat model. Neurogastroenterol Motility. 2005;17:410–4.CrossRef Liebregts T, Adam B, Bertel A, Jones S, Schulze J. Effect of E. coli Nissle, 1917 on post-inflammatory visceral sensory function in a rat model. Neurogastroenterol Motility. 2005;17:410–4.CrossRef
77.
Zurück zum Zitat Kannampalli P, Pochiraju S, Chichlowski M, Berg BM, Rudolph C. Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats. Neurogastroenterol Motil. 2014;26:1694–704.CrossRefPubMed Kannampalli P, Pochiraju S, Chichlowski M, Berg BM, Rudolph C. Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats. Neurogastroenterol Motil. 2014;26:1694–704.CrossRefPubMed
78.
Zurück zum Zitat Johnson AC, Greenwood-Van Meerveld B, McRorie J. Effects of Bifidobacterium infantis 35624 on post-inflammatory visceral hypersensitivity in the rat. Dig Dis Sci. 2011;56:3179–86.CrossRefPubMed Johnson AC, Greenwood-Van Meerveld B, McRorie J. Effects of Bifidobacterium infantis 35624 on post-inflammatory visceral hypersensitivity in the rat. Dig Dis Sci. 2011;56:3179–86.CrossRefPubMed
79.
Zurück zum Zitat Martami F, Togha M, Seifishahpar M, Ghorbani Z, Ansari H, Karimi T, et al. The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: a randomized double-blind controlled trial. Cephalalgia. 2019;39(7):841–53. https://doi.org/10.1177/0333102418820102. Epub 2019 Jan 8. PMID: 30621517.CrossRefPubMed Martami F, Togha M, Seifishahpar M, Ghorbani Z, Ansari H, Karimi T, et al. The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: a randomized double-blind controlled trial. Cephalalgia. 2019;39(7):841–53. https://​doi.​org/​10.​1177/​0333102418820102​. Epub 2019 Jan 8. PMID: 30621517.CrossRefPubMed
81.
105.
Zurück zum Zitat Singh GK, Kim IE, Girmay M, Perry C, Daus GP, Vedamuthu IP, et al. Opioid epidemic in the United States: empirical trends, and a literature review of social determinants and epidemiological, pain management, and treatment patterns. Int J Mch Aids. 2019;8(2):89–100. https://doi.org/10.21106/ijma.284. Epub 2019 Aug 8. PMID: 31723479; PMCID: PMC6804319.CrossRefPubMedPubMedCentral Singh GK, Kim IE, Girmay M, Perry C, Daus GP, Vedamuthu IP, et al. Opioid epidemic in the United States: empirical trends, and a literature review of social determinants and epidemiological, pain management, and treatment patterns. Int J Mch Aids. 2019;8(2):89–100. https://​doi.​org/​10.​21106/​ijma.​284. Epub 2019 Aug 8. PMID: 31723479; PMCID: PMC6804319.CrossRefPubMedPubMedCentral
Metadaten
Titel
The Gut Microbiota and Chronic Pain
verfasst von
Ray Pak
Michelle Cho
Keth Pride
Alaa Abd-Elsayed
Publikationsdatum
12.02.2024
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 4/2024
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-024-01221-x

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