Background
Methods
Patient population
Cardiovascular magnetic resonance imaging
CMR analysis
cDTI post-processing
Regions of interest (ROI) analysis
Segmental analysis
Inter-observer variability
Statistical analysis
Results
Baseline patient characteristics
Patient Characteristics | Value (n = 32) |
---|---|
Age (years) | 60 ± 10 |
Sex (M/F) | 28/4 |
Risk factors | |
Smoker | 7 |
Hypertension | 7 |
Diabetes | 7 |
Family history | 7 |
Peripheral vascular disease | 1 |
Characteristics at presentation | |
Culprit Coronary Artery | |
Left anterior descending artery | 16 |
Left circumflex artery | 3 |
Right coronary artery | 13 |
Microvascular obstruction | 20 |
Time from onset to balloon inflation time (min) | 231 ± 154 |
Treatment | |
Aspirin | 32 |
PY2I | 32 |
ACE inhibitor | 32 |
Beta blocker | 32 |
Parameter | Mean (n = 32) |
---|---|
Interval from PCI to CMR Time (days) | 105 ± 17 |
LVEF (%) | 44 ± 10 |
LVEDV (ml) | 171 ± 35 |
LVEDVI (ml) | 89 ± 17 |
Mean LGE (% of LV) | 22 ± 11 |
Mean infarct segment enhancement (%) | 66 ± 21 |
Infarct size (g) | 18 ± 12 |
Global radial strain (%) | 19 ± 6 |
Global circumferential strain (%) | − 13 ± 3 |
Global longitudinal strain (%) | − 10 ± 3 |
DTI in chronically infarcted myocardium
Parameter | pEF (n = 8) | mEF (n = 14) | rEF (n = 10) | ANOVA P Value |
---|---|---|---|---|
LGE (SEG) | 49 ± 17 | 66 ± 20 | 81 ± 16 | 0.004 |
Infarct Size | 13 ± 8 | 16 ± 10 | 28 ± 12 | 0.011 |
cDTI | ||||
MD(ROI) (× 10−3mm2/s) | 1.6 ± 0.1 | 1.7 ± 0.1 | 1.9 ± 0.1 | < 0.001 |
FA(ROI) | 0.3 ± 0.2 | 0.3 ± 0.3 | 0.2 ± 0.3 | 0.002 |
Absolute E2A(SEG) (Degrees) | 51 ± 5 | 43 ± 5 | 35 ± 7 | < 0.001 |
Helix angles | ||||
RHM(SEG) (%) | 17.0 ± 2.6 | 12.4 ± 3.0 | 7.6 ± 3.3 | < 0.001 |
CM(SEG) (%) | 73.5 ± 7.2 | 71.1 ± 10.6 | 69.4 ± 9.4 | 0.664 |
LHM(SEG) (%) | 8.5 ± 5.2 | 17.8 ± 10.2 | 23.6 ± 8.8 | 0.004 |
Strain | ||||
Global radial strain (%) | 26.3 ± 6.6 | 17.8 ± 3.4 | 14.1 ± 3.5 | < 0.001 |
Global longitudinal strain (%) | − 12.9 ± 2.5 | − 10.5 ± 2.4 | − 7.4 ± 2.6 | < 0.001 |
Global circumferential strain (%) | − 15.7 ± 3.3 | − 12.4 ± 1.4 | − 11.1 ± 2.9 | 0.002 |
Radial strain in infarct segments (%) | 16.5 ± 9.6 | 13.7 ± 6.8 | 8.5 ± 3.7 | 0.051 |
Longitudinal strain in infarct segments (%) | − 13.7 ± 4.1 | − 10.1 ± 3.5 | − 6.9 ± 2.1 | < 0.001 |
Circumferential strain in infarct segments (%) | − 14.0 ± 7.4 | − 8.4 ± 5.4 | − 6.8 ± 6.1 | 0.052 |