Skip to main content
Erschienen in: Current Pain and Headache Reports 10/2023

05.08.2023 | Hot Topics in Pain and Headache (N Rosen, Section Editor)

The Role of Step Therapy in the Treatment of Migraine

verfasst von: Leon S. Moskatel, Niushen Zhang

Erschienen in: Current Pain and Headache Reports | Ausgabe 10/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

This review examines recent evidence and applies bioethical principles to evaluate the benefits and risks of using step therapy in the treatment of migraine.

Recent Findings

With the CGRP mAbs, gepants, and lasmiditan now on the market for up to 5 years, new research, including network meta-analyses and long-term use studies, can evaluate the comparative efficacy, tolerability, and adherence of these medications relative to older acute and preventive medications for the treatment of migraine.

Summary

Deciding how medications are chosen for patients requires accounting for many factors including sustainability, efficacy, tolerability, and preference. Newer research can help give clarity on the appropriateness of gating certain treatment options behind others.
Literatur
1.
Zurück zum Zitat Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I, Charlson F, Davis A, Degenhardt L, Dicker D, Duan L. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743–800.CrossRef Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I, Charlson F, Davis A, Degenhardt L, Dicker D, Duan L. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743–800.CrossRef
2.
Zurück zum Zitat Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: updated age, sex, and socioeconomic‐specific estimates from government health surveys. Headache: J Head Face Pain. 2021;61(1):60–8. Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: updated age, sex, and socioeconomic‐specific estimates from government health surveys. Headache: J Head Face Pain. 2021;61(1):60–8.
3.
Zurück zum Zitat Raval AD, Shah A. National trends in direct health care expenditures among US adults with migraine: 2004 to 2013. J Pain. 2017;18(1):96–107.CrossRefPubMed Raval AD, Shah A. National trends in direct health care expenditures among US adults with migraine: 2004 to 2013. J Pain. 2017;18(1):96–107.CrossRefPubMed
4.
Zurück zum Zitat • Gilligan AM, Foster SA, Sainski-Nguyen A, Sedgley R, Smith D, Morrow P. Direct and indirect costs among United States commercially insured employees with migraine. J Occup Environ Med. 2018;60(12):1120–7. Assessment of healthcare costs of patients with migraine. • Gilligan AM, Foster SA, Sainski-Nguyen A, Sedgley R, Smith D, Morrow P. Direct and indirect costs among United States commercially insured employees with migraine. J Occup Environ Med. 2018;60(12):1120–7. Assessment of healthcare costs of patients with migraine.
5.
Zurück zum Zitat Devine J, Hadsall R, Cline R, Schommer J, Virnig B. Effect of daily migraine prevention on health care utilisation in an insured patient population. J Headache Pain. 2007;8:105–13.CrossRefPubMedPubMedCentral Devine J, Hadsall R, Cline R, Schommer J, Virnig B. Effect of daily migraine prevention on health care utilisation in an insured patient population. J Headache Pain. 2007;8:105–13.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Lainez MJ. The effect of migraine prophylaxis on migraine-related resource use and productivity. CNS Drugs. 2009;23:727–38.CrossRefPubMed Lainez MJ. The effect of migraine prophylaxis on migraine-related resource use and productivity. CNS Drugs. 2009;23:727–38.CrossRefPubMed
7.
Zurück zum Zitat Wertz DA, Quimbo RM, Yaldo AZ, Rupnow MF. Resource utilization impact of topiramate for migraine prevention in the managed-care setting. Curr Med Res Opin. 2009;25(2):499–503.CrossRefPubMed Wertz DA, Quimbo RM, Yaldo AZ, Rupnow MF. Resource utilization impact of topiramate for migraine prevention in the managed-care setting. Curr Med Res Opin. 2009;25(2):499–503.CrossRefPubMed
8.
Zurück zum Zitat Borges dos Santos MA, dos Santos Dias LL, Santos Pinto CD, da Silva RM, Osorio-de-Castro CG. Factors influencing pharmaceutical pricing-a scoping review of academic literature in health science. J Pharm Policy Pract. 2019;12:1–2. Borges dos Santos MA, dos Santos Dias LL, Santos Pinto CD, da Silva RM, Osorio-de-Castro CG. Factors influencing pharmaceutical pricing-a scoping review of academic literature in health science. J Pharm Policy Pract. 2019;12:1–2.
13.
Zurück zum Zitat Hoffman S. Step therapy. Food Drug Law J. 2018;73(1):38–65. Hoffman S. Step therapy. Food Drug Law J. 2018;73(1):38–65.
14.
Zurück zum Zitat Sedghi T, Gronbeck C, Aiudi DA, Grant-Kels JM. Assessing the ethics of prior authorization denials and step therapy policies in dermatology. J Am Acad Dermatol. 2023. Sedghi T, Gronbeck C, Aiudi DA, Grant-Kels JM. Assessing the ethics of prior authorization denials and step therapy policies in dermatology. J Am Acad Dermatol. 2023.
15.
Zurück zum Zitat Silberstein SD, Winner PK, Chmiel JJ. Migraine preventive medication reduces resource utilization. Headache: J Head Face Pain. 2003;43(3):171–8. Silberstein SD, Winner PK, Chmiel JJ. Migraine preventive medication reduces resource utilization. Headache: J Head Face Pain. 2003;43(3):171–8.
16.
Zurück zum Zitat Etemad LR, Yang W, Globe D, Barlev A, Johnson KA. Costs and utilization of triptan users who receive drug prophylaxis for migraine versus triptan users who do not receive drug prophylaxis. J Manag Care Pharm. 2005;11(2):137–44.PubMed Etemad LR, Yang W, Globe D, Barlev A, Johnson KA. Costs and utilization of triptan users who receive drug prophylaxis for migraine versus triptan users who do not receive drug prophylaxis. J Manag Care Pharm. 2005;11(2):137–44.PubMed
17.
Zurück zum Zitat Feliu AL, Rupnow MF, Blount A, Boccuzzi SJ, Vermilyea J. Resource use associated with topiramate in migraine prophylaxis. Am J Health-Syst pharm. 2007;64(14):1483–91.CrossRefPubMed Feliu AL, Rupnow MF, Blount A, Boccuzzi SJ, Vermilyea J. Resource use associated with topiramate in migraine prophylaxis. Am J Health-Syst pharm. 2007;64(14):1483–91.CrossRefPubMed
18.
Zurück zum Zitat Silberstein SD, Feliu AL, Rupnow MF, Blount AC, Boccuzzi SJ. Topiramate in migraine prophylaxis: long‐term impact on resource utilization and cost. Headache: J Head Face Pain. 2007;47(4):500–10. Silberstein SD, Feliu AL, Rupnow MF, Blount AC, Boccuzzi SJ. Topiramate in migraine prophylaxis: long‐term impact on resource utilization and cost. Headache: J Head Face Pain. 2007;47(4):500–10.
19.
Zurück zum Zitat • Foster SA, Hoyt M, Ye W, Mason O, Ford JH. Direct cost and healthcare resource utilization of patients with migraine before treatment initiation with calcitonin gene-related peptide monoclonal antibodies by the number of prior preventive migraine medication classes. Curr Med Res Opin. 2022;38(5):653–60. Examines underexplored topic of economic effect of medication non-responders. • Foster SA, Hoyt M, Ye W, Mason O, Ford JH. Direct cost and healthcare resource utilization of patients with migraine before treatment initiation with calcitonin gene-related peptide monoclonal antibodies by the number of prior preventive migraine medication classes. Curr Med Res Opin. 2022;38(5):653–60. Examines underexplored topic of economic effect of medication non-responders.
20.
Zurück zum Zitat Khanal S, Underwood M, Naghdi S, Brown A, Duncan C, Matharu M, Mistry H. A systematic review of economic evaluations of pharmacological treatments for adults with chronic migraine. J Headache Pain. 2022;23(1):122.CrossRefPubMedPubMedCentral Khanal S, Underwood M, Naghdi S, Brown A, Duncan C, Matharu M, Mistry H. A systematic review of economic evaluations of pharmacological treatments for adults with chronic migraine. J Headache Pain. 2022;23(1):122.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Rothrock JF, Bloudek LM, Houle TT, Andress‐Rothrock D, Varon SF. Real‐world economic impact of onabotulinumtoxin A in patients with chronic migraine. Headache: J Head Face Pain. 2014;54(10):1565–73. Rothrock JF, Bloudek LM, Houle TT, Andress‐Rothrock D, Varon SF. Real‐world economic impact of onabotulinumtoxin A in patients with chronic migraine. Headache: J Head Face Pain. 2014;54(10):1565–73.
22.
Zurück zum Zitat Messali A, Owens G, Bloudek L, Kori S, Cole A, Chia J. Health care resource utilization following initiation of a triptan: a retrospective claims analysis. J Manag Care Pharm. 2014;20(4):368–75. Messali A, Owens G, Bloudek L, Kori S, Cole A, Chia J. Health care resource utilization following initiation of a triptan: a retrospective claims analysis. J Manag Care Pharm. 2014;20(4):368–75.
23.
Zurück zum Zitat Marcus SC, Shewale AR, Silberstein SD, Lipton RB, Young WB, Viswanathan HN, Doshi JA. Comparison of healthcare resource utilization and costs among patients with migraine with potentially adequate and insufficient triptan response. Cephalalgia. 2020;40(7):639–49.CrossRefPubMedPubMedCentral Marcus SC, Shewale AR, Silberstein SD, Lipton RB, Young WB, Viswanathan HN, Doshi JA. Comparison of healthcare resource utilization and costs among patients with migraine with potentially adequate and insufficient triptan response. Cephalalgia. 2020;40(7):639–49.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Wilper A, Woolhandler S, Himmelstein D, Nardin R. Impact of insurance status on migraine care in the United States: a population-based study. Neurology. 2010;74(15):1178–83.CrossRefPubMed Wilper A, Woolhandler S, Himmelstein D, Nardin R. Impact of insurance status on migraine care in the United States: a population-based study. Neurology. 2010;74(15):1178–83.CrossRefPubMed
26.
Zurück zum Zitat Minen MT, Lindberg K, Langford A, Loder E. Variation in prescription drug coverage for triptans: analysis of insurance formularies. Headache: J Head Face Pain. 2017;57(8):1243–51. Minen MT, Lindberg K, Langford A, Loder E. Variation in prescription drug coverage for triptans: analysis of insurance formularies. Headache: J Head Face Pain. 2017;57(8):1243–51.
27.
Zurück zum Zitat Wang V, Bieser S, Lowe A, Li M, Yuan H. CGRP antagonist (gepant) vs triptan use profiles in individuals with migraine: a multicenter electronic medical record analysis of patient characteristics and emergency department services utilization (P6–12.010). Wang V, Bieser S, Lowe A, Li M, Yuan H. CGRP antagonist (gepant) vs triptan use profiles in individuals with migraine: a multicenter electronic medical record analysis of patient characteristics and emergency department services utilization (P6–12.010).
28.
Zurück zum Zitat • Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, Sehgal N, Kuester J. A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headache. PloSOne. 2015;10(7):e0130733. Older but thorough examination of comparative efficacy of preventive medication. • Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, Sehgal N, Kuester J. A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headache. PloSOne. 2015;10(7):e0130733. Older but thorough examination of comparative efficacy of preventive medication.
29.
Zurück zum Zitat • Ehrlich M, Hentschke C, Sieder C, Maier-Peuschel M, Reuter U. Erenumab versus topiramate: post hoc efficacy analysis from the HER-MES study. J Headache Pain. 2022;23(1):1–8. One of only studies comparing a CGRP mAb with an oral preventive. • Ehrlich M, Hentschke C, Sieder C, Maier-Peuschel M, Reuter U. Erenumab versus topiramate: post hoc efficacy analysis from the HER-MES study. J Headache Pain. 2022;23(1):1–8. One of only studies comparing a CGRP mAb with an oral preventive.
30.
Zurück zum Zitat Overeem LH, Raffaelli B, Mecklenburg J, Kelderman T, Neeb L, Reuter U. Indirect comparison of topiramate and monoclonal antibodies against CGRP or its receptor for the prophylaxis of episodic migraine: a systematic review with meta-analysis. CNS Drugs. 2021;35:805–20.CrossRefPubMedPubMedCentral Overeem LH, Raffaelli B, Mecklenburg J, Kelderman T, Neeb L, Reuter U. Indirect comparison of topiramate and monoclonal antibodies against CGRP or its receptor for the prophylaxis of episodic migraine: a systematic review with meta-analysis. CNS Drugs. 2021;35:805–20.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat •• Frank F, Ulmer H, Sidoroff V, Broessner G. CGRP-antibodies, topiramate and botulinum toxin type A in episodic and chronic migraine: a systematic review and meta-analysis. Cephalalgia. 2021;41(11–12):1222–39. Comparison of CGRP mAbs, onabotA, and an oral preventive. •• Frank F, Ulmer H, Sidoroff V, Broessner G. CGRP-antibodies, topiramate and botulinum toxin type A in episodic and chronic migraine: a systematic review and meta-analysis. Cephalalgia. 2021;41(11–12):1222–39. Comparison of CGRP mAbs, onabotA, and an oral preventive.
32.
Zurück zum Zitat Alpuente A, Gallardo VJ, Caronna E, Torres-Ferrús M, Pozo-Rosich P. Partial and nonresponders to onabotulinumtoxinA can benefit from anti-CGRP monoclonal antibodies preventive treatment: a real-world evidence study. Euro J Neurol. 2021;28(7):2378–82.CrossRef Alpuente A, Gallardo VJ, Caronna E, Torres-Ferrús M, Pozo-Rosich P. Partial and nonresponders to onabotulinumtoxinA can benefit from anti-CGRP monoclonal antibodies preventive treatment: a real-world evidence study. Euro J Neurol. 2021;28(7):2378–82.CrossRef
33.
Zurück zum Zitat Goldstein J, Silberstein SD, Saper JR, Ryan Jr RE, Lipton RB. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double‐blind, randomized, parallel‐group, single‐dose, placebo‐controlled study. Headache: J Head Face Pain. 2006;46(3):444–53. Goldstein J, Silberstein SD, Saper JR, Ryan Jr RE, Lipton RB. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double‐blind, randomized, parallel‐group, single‐dose, placebo‐controlled study. Headache: J Head Face Pain. 2006;46(3):444–53.
34.
Zurück zum Zitat Jafari S, Khayyamfar F, Ansari I, Jafari R, Afshinmajd S. Comparison of ibuprofen and AAC (acetaminophen, aspirin, caffeine) for treating acute migraine episodes. J Basic Clin Pathophysiol. 2018;6(2):1–6. Jafari S, Khayyamfar F, Ansari I, Jafari R, Afshinmajd S. Comparison of ibuprofen and AAC (acetaminophen, aspirin, caffeine) for treating acute migraine episodes. J Basic Clin Pathophysiol. 2018;6(2):1–6.
35.
Zurück zum Zitat Misra UK, Kalita J, Yadav RK. Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial. J Headache Pain. 2007;8:175–9. Misra UK, Kalita J, Yadav RK. Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial. J Headache Pain. 2007;8:175–9.
36.
Zurück zum Zitat Pini LA, Guerzoni S, Cainazzo M, Ciccarese M, Prudenzano MP, Livrea P. Comparison of tolerability and efficacy of a combination of paracetamol+ caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study. J Headache Pain. 2012;13:669–75.CrossRefPubMedPubMedCentral Pini LA, Guerzoni S, Cainazzo M, Ciccarese M, Prudenzano MP, Livrea P. Comparison of tolerability and efficacy of a combination of paracetamol+ caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study. J Headache Pain. 2012;13:669–75.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J. Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache: J Head Face Pain. 2005;45(8):973–82. Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J. Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache: J Head Face Pain. 2005;45(8):973–82.
38.
Zurück zum Zitat Lipton RB, Bigal ME, Goadsby PJ. Double-blind clinical trials of oral triptans vs other classes of acute migraine medication—a review. Cephalalgia. 2004;24(5):321–32.CrossRefPubMed Lipton RB, Bigal ME, Goadsby PJ. Double-blind clinical trials of oral triptans vs other classes of acute migraine medication—a review. Cephalalgia. 2004;24(5):321–32.CrossRefPubMed
39.
Zurück zum Zitat Xu H, Han W, Wang J, Li M. Network meta-analysis of migraine disorder treatment by NSAIDs and triptans. J Headache Pain. 2016;17(1):1–8.CrossRef Xu H, Han W, Wang J, Li M. Network meta-analysis of migraine disorder treatment by NSAIDs and triptans. J Headache Pain. 2016;17(1):1–8.CrossRef
40.
Zurück zum Zitat Hou M, Liu H, Li Y, Xu L, He Y, Lv Y, Zheng Q, Li L. Efficacy of triptans for the treatment of acute migraines: a quantitative comparison based on the dose-effect and time-course characteristics. Euro J Clin Pharmacol. 2019;75:1369–78.CrossRef Hou M, Liu H, Li Y, Xu L, He Y, Lv Y, Zheng Q, Li L. Efficacy of triptans for the treatment of acute migraines: a quantitative comparison based on the dose-effect and time-course characteristics. Euro J Clin Pharmacol. 2019;75:1369–78.CrossRef
41.
Zurück zum Zitat •• Johnston K, Popoff E, Deighton A, Dabirvaziri P, Harris L, Thiry A, Croop R, Coric V, L’Italien G, Moren J. Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis. Expert Rev Pharmacoecon Outcomes Res. 2022;22(1):155–66. One of few studies looking at comparative efficacy and tolerability of the gepants and lasmiditan. •• Johnston K, Popoff E, Deighton A, Dabirvaziri P, Harris L, Thiry A, Croop R, Coric V, L’Italien G, Moren J. Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis. Expert Rev Pharmacoecon Outcomes Res. 2022;22(1):155–66. One of few studies looking at comparative efficacy and tolerability of the gepants and lasmiditan.
42.
Zurück zum Zitat •• Yang CP, Liang CS, Chang CM, Yang CC, Shih PH, Yau YC, Tang KT, Wang SJ. Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis. JAMA network open. 2021;4(10):e2128544-. Comparison of new and old acute treatments for migraine. •• Yang CP, Liang CS, Chang CM, Yang CC, Shih PH, Yau YC, Tang KT, Wang SJ. Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis. JAMA network open. 2021;4(10):e2128544-. Comparison of new and old acute treatments for migraine.
43.
Zurück zum Zitat Hepp Z, Dodick DW, Varon SF, Gillard P, Hansen RN, Devine EB. Adherence to oral migraine-preventive medications among patients with chronic migraine. Cephalalgia. 2015;35(6):478–88.CrossRefPubMed Hepp Z, Dodick DW, Varon SF, Gillard P, Hansen RN, Devine EB. Adherence to oral migraine-preventive medications among patients with chronic migraine. Cephalalgia. 2015;35(6):478–88.CrossRefPubMed
44.
Zurück zum Zitat He A, Song D, Zhang L, Li C. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. J Headache Pain. 2017;18(1):1–7.CrossRef He A, Song D, Zhang L, Li C. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. J Headache Pain. 2017;18(1):1–7.CrossRef
45.
Zurück zum Zitat Vécsei L, Majláth Z, Szok D, Csáti A, Tajti J. Drug safety and tolerability in prophylactic migraine treatment. Expert Opin Drug Saf. 2015;14(5):667–81.CrossRefPubMed Vécsei L, Majláth Z, Szok D, Csáti A, Tajti J. Drug safety and tolerability in prophylactic migraine treatment. Expert Opin Drug Saf. 2015;14(5):667–81.CrossRefPubMed
46.
Zurück zum Zitat Kangasniemi P, Hedman C. Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A double-blind study Cephalalgia. 1984;4(2):91–6.PubMed Kangasniemi P, Hedman C. Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A double-blind study Cephalalgia. 1984;4(2):91–6.PubMed
47.
Zurück zum Zitat Couch JR, Amitriptyline Versus Placebo Study Group. Amitriptyline in the prophylactic treatment of migraine and chronic daily headache. Headache: J Head Face Pain. 2011;51(1):33–51. Couch JR, Amitriptyline Versus Placebo Study Group. Amitriptyline in the prophylactic treatment of migraine and chronic daily headache. Headache: J Head Face Pain. 2011;51(1):33–51.
48.
Zurück zum Zitat Couch JR, Hassanein RS. Amitriptyline in migraine prophylaxis. Arch Neurol. 1979;36(11):695–9.CrossRefPubMed Couch JR, Hassanein RS. Amitriptyline in migraine prophylaxis. Arch Neurol. 1979;36(11):695–9.CrossRefPubMed
49.
Zurück zum Zitat Ahmed F, Gaul C, García-Moncó JC, Sommer K, Martelletti P. An open-label prospective study of the real-life use of onabotulinumtoxinA for the treatment of chronic migraine: the REPOSE study. J Headache Pain. 2019;20(1):1–4.CrossRef Ahmed F, Gaul C, García-Moncó JC, Sommer K, Martelletti P. An open-label prospective study of the real-life use of onabotulinumtoxinA for the treatment of chronic migraine: the REPOSE study. J Headache Pain. 2019;20(1):1–4.CrossRef
50.
Zurück zum Zitat Guerzoni S, Pellesi L, Baraldi C, Cainazzo MM, Negro A, Martelletti P, Pini LA. Long-term treatment benefits and prolonged efficacy of onabotulinumtoxinA in patients affected by chronic migraine and medication overuse headache over 3 years of therapy. Front Neurol. 2017;8:586.CrossRefPubMedPubMedCentral Guerzoni S, Pellesi L, Baraldi C, Cainazzo MM, Negro A, Martelletti P, Pini LA. Long-term treatment benefits and prolonged efficacy of onabotulinumtoxinA in patients affected by chronic migraine and medication overuse headache over 3 years of therapy. Front Neurol. 2017;8:586.CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Argyriou AA, Dermitzakis EV, Vlachos GS, Vikelis M. Long-term adherence, safety, and efficacy of repeated onabotulinumtoxinA over five years in chronic migraine prophylaxis. Acta Neurol Scand. 2022;145(6):676–83.CrossRefPubMed Argyriou AA, Dermitzakis EV, Vlachos GS, Vikelis M. Long-term adherence, safety, and efficacy of repeated onabotulinumtoxinA over five years in chronic migraine prophylaxis. Acta Neurol Scand. 2022;145(6):676–83.CrossRefPubMed
52.
Zurück zum Zitat Yalinay Dikmen P, Kosak S, Ilgaz Aydinlar E, Sagduyu KA. A single-center retrospective study of onabotulinumtoxinA for treatment of 245 chronic migraine patients: survey results of a real-world experience. Acta Neurol Belg. 2018;118(3):475–84.CrossRefPubMed Yalinay Dikmen P, Kosak S, Ilgaz Aydinlar E, Sagduyu KA. A single-center retrospective study of onabotulinumtoxinA for treatment of 245 chronic migraine patients: survey results of a real-world experience. Acta Neurol Belg. 2018;118(3):475–84.CrossRefPubMed
53.
Zurück zum Zitat Vandervorst F, Van Deun L, Van Dycke A, Paemeleire K, Reuter U, Schoenen J, Versijpt J. CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs. J Headache Pain. 2021;22:1–1.CrossRef Vandervorst F, Van Deun L, Van Dycke A, Paemeleire K, Reuter U, Schoenen J, Versijpt J. CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs. J Headache Pain. 2021;22:1–1.CrossRef
54.
Zurück zum Zitat Krasenbaum LJ, Pedarla VL, Thompson SF, Tangirala K, Cohen JM, Driessen MT. A real-world study of acute and preventive medication use, adherence, and persistence in patients prescribed fremanezumab in the United States. J Headache Pain. 2022;23(1):54.CrossRefPubMedPubMedCentral Krasenbaum LJ, Pedarla VL, Thompson SF, Tangirala K, Cohen JM, Driessen MT. A real-world study of acute and preventive medication use, adherence, and persistence in patients prescribed fremanezumab in the United States. J Headache Pain. 2022;23(1):54.CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Pozo-Rosich P, Detke HC, Wang S, Doležil D, Li LQ, Aurora SK, Reuter U. Long-term treatment with galcanezumab in patients with chronic migraine: results from the open-label extension of the REGAIN study. Curr Med Res Opin. 2022;38(5):731–42.CrossRefPubMed Pozo-Rosich P, Detke HC, Wang S, Doležil D, Li LQ, Aurora SK, Reuter U. Long-term treatment with galcanezumab in patients with chronic migraine: results from the open-label extension of the REGAIN study. Curr Med Res Opin. 2022;38(5):731–42.CrossRefPubMed
56.
Zurück zum Zitat Tinsley A, Rothrock JF. Safety and tolerability of preventive treatment options for chronic migraine. Expert Opin Drug Saf. 2021;20(12):1523–33.CrossRefPubMed Tinsley A, Rothrock JF. Safety and tolerability of preventive treatment options for chronic migraine. Expert Opin Drug Saf. 2021;20(12):1523–33.CrossRefPubMed
57.
Zurück zum Zitat Camporeale A, Kudrow D, Sides R, Wang S, Van Dycke A, Selzler KJ, Stauffer VL. A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine. BMC Neurol. 2018;18(1):1–2.CrossRef Camporeale A, Kudrow D, Sides R, Wang S, Van Dycke A, Selzler KJ, Stauffer VL. A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine. BMC Neurol. 2018;18(1):1–2.CrossRef
58.
Zurück zum Zitat Lambru G, Hill B, Murphy M, Tylova I, Andreou AP. A prospective real-world analysis of erenumab in refractory chronic migraine. J Headache Pain. 2020;21:1.CrossRef Lambru G, Hill B, Murphy M, Tylova I, Andreou AP. A prospective real-world analysis of erenumab in refractory chronic migraine. J Headache Pain. 2020;21:1.CrossRef
59.
Zurück zum Zitat Ornello R, Casalena A, Frattale I, Gabriele A, Affaitati G, Giamberardino MA, Assetta M, Maddestra M, Marzoli F, Viola S, Cerone D. Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy. J Headache Pain. 2020;21:1–1.CrossRef Ornello R, Casalena A, Frattale I, Gabriele A, Affaitati G, Giamberardino MA, Assetta M, Maddestra M, Marzoli F, Viola S, Cerone D. Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy. J Headache Pain. 2020;21:1–1.CrossRef
60.
Zurück zum Zitat Saely S, Croteau D, Jawidzik L, Brinker A, Kortepeter C. Hypertension: a new safety risk for patients treated with erenumab. Headache: J Head Face Pain. 2021;61(1):202–8. Saely S, Croteau D, Jawidzik L, Brinker A, Kortepeter C. Hypertension: a new safety risk for patients treated with erenumab. Headache: J Head Face Pain. 2021;61(1):202–8.
61.
Zurück zum Zitat Ashina M, Kudrow D, Reuter U, Dolezil D, Silberstein S, Tepper SJ, Xue F, Picard H, Zhang F, Wang A, Zhou Y. Long-term tolerability and nonvascular safety of erenumab, a novel calcitonin gene-related peptide receptor antagonist for prevention of migraine: a pooled analysis of four placebo-controlled trials with long-term extensions. Cephalalgia. 2019;39(14):1798–808.CrossRefPubMed Ashina M, Kudrow D, Reuter U, Dolezil D, Silberstein S, Tepper SJ, Xue F, Picard H, Zhang F, Wang A, Zhou Y. Long-term tolerability and nonvascular safety of erenumab, a novel calcitonin gene-related peptide receptor antagonist for prevention of migraine: a pooled analysis of four placebo-controlled trials with long-term extensions. Cephalalgia. 2019;39(14):1798–808.CrossRefPubMed
62.
Zurück zum Zitat •• Ashina M, Goadsby PJ, Reuter U, Silberstein S, Dodick DW, Xue F, Zhang F, Paiva da Silva Lima G, Cheng S, Mikol DD. Long‐term efficacy and safety of erenumab in migraine prevention: results from a 5‐year, open‐label treatment phase of a randomized clinical trial. European journal of neurology. 2021 May;28(5):1716–25. Longest study to date on efficacy and safety of a CGRP mAb. •• Ashina M, Goadsby PJ, Reuter U, Silberstein S, Dodick DW, Xue F, Zhang F, Paiva da Silva Lima G, Cheng S, Mikol DD. Long‐term efficacy and safety of erenumab in migraine prevention: results from a 5‐year, open‐label treatment phase of a randomized clinical trial. European journal of neurology. 2021 May;28(5):1716–25. Longest study to date on efficacy and safety of a CGRP mAb.
63.
Zurück zum Zitat Thorlund K, Toor K, Wu P, Chan K, Druyts E, Ramos E, Bhambri R, Donnet A, Stark R, Goadsby PJ. Comparative tolerability of treatments for acute migraine: a network meta-analysis. Cephalalgia. 2017;37(10):965–78.CrossRefPubMed Thorlund K, Toor K, Wu P, Chan K, Druyts E, Ramos E, Bhambri R, Donnet A, Stark R, Goadsby PJ. Comparative tolerability of treatments for acute migraine: a network meta-analysis. Cephalalgia. 2017;37(10):965–78.CrossRefPubMed
64.
Zurück zum Zitat Lipton RB, Marcus SC, Shewale AR, Dodick DW, Viswanathan HN, Doshi JA. Acute treatment patterns in patients with migraine newly initiating a triptan. Cephalalgia. 2020;40(5):437–47.CrossRefPubMedPubMedCentral Lipton RB, Marcus SC, Shewale AR, Dodick DW, Viswanathan HN, Doshi JA. Acute treatment patterns in patients with migraine newly initiating a triptan. Cephalalgia. 2020;40(5):437–47.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Yang CP, Liang CS, Chang CM, Yang CC, Shih PH, Yau YC, Tang KT, Wang SJ. Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis. JAMA network open. 2021;4(10):e2128544-. Yang CP, Liang CS, Chang CM, Yang CC, Shih PH, Yau YC, Tang KT, Wang SJ. Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis. JAMA network open. 2021;4(10):e2128544-.
66.
Zurück zum Zitat Johnston K, Popoff E, Deighton A, Dabirvaziri P, Harris L, Thiry A, Croop R, Coric V, L’Italien G, Moren J. Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis. Expert Rev of Pharmacoecon Outcomes Res. 2022;22(1):155–66.CrossRef Johnston K, Popoff E, Deighton A, Dabirvaziri P, Harris L, Thiry A, Croop R, Coric V, L’Italien G, Moren J. Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis. Expert Rev of Pharmacoecon Outcomes Res. 2022;22(1):155–66.CrossRef
Metadaten
Titel
The Role of Step Therapy in the Treatment of Migraine
verfasst von
Leon S. Moskatel
Niushen Zhang
Publikationsdatum
05.08.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 10/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01155-w

Weitere Artikel der Ausgabe 10/2023

Current Pain and Headache Reports 10/2023 Zur Ausgabe

ACUTE PAIN MEDICINE (R URMAN, SECTION EDITOR)

Low-Level Laser Therapy for Acute Pain: A Comprehensive Review

Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

Serological Biomarkers of Chronic Migraine

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

03.06.2024 Urologische Notfallmedizin Nachrichten

Wer ihn je erlebt hat, wird ihn nicht vergessen: den Schmerz, den die beim Öffnen oder Schließen des Reißverschlusses am Hosenschlitz eingeklemmte Haut am Penis oder Skrotum verursacht. Eine neue Methode für rasche Abhilfe hat ein US-Team getestet.

Schlaganfall: frühzeitige Blutdrucksenkung im Krankenwagen ohne Nutzen

31.05.2024 Apoplex Nachrichten

Der optimale Ansatz für die Blutdruckkontrolle bei Patientinnen und Patienten mit akutem Schlaganfall ist noch nicht gefunden. Ob sich eine frühzeitige Therapie der Hypertonie noch während des Transports in die Klinik lohnt, hat jetzt eine Studie aus China untersucht.

Reanimation bei Kindern – besser vor Ort oder während Transport?

29.05.2024 Reanimation im Kindesalter Nachrichten

Zwar scheint es laut einer Studie aus den USA und Kanada bei der Reanimation von Kindern außerhalb einer Klinik keinen Unterschied für das Überleben zu machen, ob die Wiederbelebungsmaßnahmen während des Transports in die Klinik stattfinden oder vor Ort ausgeführt werden. Jedoch gibt es dabei einige Einschränkungen und eine wichtige Ausnahme.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.