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Journal of Neurology

Erschienen in:

16.04.2023 | Original Communication

Changes in motor activity level in individuals with frontotemporal dementia

verfasst von: C. R. A. Silveira, E. Mitchell, M. Restrepo-Martinez, K. Coleman, R. Ruiz-Garcia, E. Finger

Erschienen in: Journal of Neurology | Ausgabe 8/2023

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Abstract

Changes in motor activity are common in individuals with Frontotemporal dementia (FTD). Yet, it remains unclear why some individuals become motorically hyperactive, while others hypoactive even in early stages of the disease. This study aimed to examine the relationship between motor activity level and (1) FTD clinical subtype, and (2) cortical thickness and subcortical volumes. Eighty-two charts were retrospectively reviewed from patients meeting consensus criteria for one of the three main clinical subtypes of FTD: probable bvFTD, semantic variant Primary Progressive Aphasia (PPA), or non-fluent variant PPA. Participants were assigned to one of three groups: (1) hyperactive, (2) hypoactive, or (3) no record of change. Hyperactivity was prevalent among bvFTD (58.5%) and semantic PPA (68.8%) subtypes while hypoactivity was less common in both subtypes (29.3% and 18.8%, respectively). The majority of patients with non-fluent PPA showed no record of change in motor activity (66.7%). The analysis of cortical thickness and subcortical volumes did not identify significant associations with motor activity levels. In conclusion, increased motor activity is highly prevalent among individuals with FTD, especially bvFTD and svPPA subtypes. These findings may inform prognosis and prediction of changes in motor activity, and allow planning for appropriate environmental and behavioural interventions. Future studies with prospective, standardized longitudinal collection of information regarding the type and level of change in motor activity, including wearable measures of actigraphy, may help to further delineate the onset and progression of abnormal motor behaviours and determine neuroanatomic associations in FTD.

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Carrarini C, Russo M, Dono F et al (2021) Agitation and dementia: prevention and treatment strategies in acute and chronic conditions. Front Neurol 12:1–18. https://doi.org/10.3389/fneur.2021.644317CrossRef

Rosen HJ, Allison SC, Schauer GF et al (2005) Neuroanatomical correlates of behavioural disorders in dementia. Brain 128(11):2612–2625. https://doi.org/10.1093/brain/awh628CrossRefPubMed

Liu W, Miller BL, Kramer JH et al (2004) Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology 62(5):742–748. https://doi.org/10.1212/01.wnl.0000113729.77161.c9CrossRefPubMed

Kazui H, Yoshiyama K, Kanemoto H et al (2016) Differences of behavioral and psychological symptoms of dementia in disease severity in four major dementias. PLoS One 11(8): e0161092. https://doi.org/10.1371/journal.pone.0161092.

Marczinski CA, Davidson W, Kertesz A (2004) A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cogn Behav Neurol 17(4):185–190PubMed

Snowden JS, Bathgate D, Varma A et al (2001) Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry 70(3):323–332. https://doi.org/10.1136/jnnp.70.3.323CrossRefPubMedPubMedCentral

Zamboni G, Huey ED, Krueger F et al (2008) Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology 71(10):736–742. https://doi.org/10.1212/01.wnl.0000324920.96835.95CrossRefPubMedPubMedCentral

Bhatia KP, Marsden CD (1994) The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 117(4):859–876. https://doi.org/10.1093/brain/117.4.859CrossRefPubMed

Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118(1):279–306. https://doi.org/10.1093/brain/118.1.279CrossRefPubMed

10.

Mega MS, Cohenour RC (1997) Akinetic mutism: disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychol Behav Neurol 10(4):254–259PubMed

11.

Jahanshahi M (1998) Willed action and its impairments. Cogn Neuropsychol 15(6–8):483–533. https://doi.org/10.1080/026432998381005CrossRefPubMed

12.

Siegel JS, Snyder AZ, Metcalf NV et al (2014) The circuitry of abulia: insights from functional connectivity MRI. NeuroImage Clin 6:320–326. https://doi.org/10.1016/j.nicl.2014.09.012CrossRefPubMedPubMedCentral

13.

Rascovsky K, Hodges JR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia” Brain 134(9): 2456–2477. doi: https://doi.org/10.1093/brain/awr179.

14.

Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. J Psychiatr Res 12(3):189–198. https://doi.org/10.1016/0022-3956(75)90026-6CrossRefPubMed

15.

Nasreddine ZS, Phillips NA, Bedirian V et al (2005) The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.xCrossRefPubMed

16.

Mitchell E, Tavares TP, Palaniyappan L et al (2019) Hoarding and obsessive-compulsive behaviours in frontotemporal dementia: clinical and neuroanatomic associations. Cortex 121:443–453. https://doi.org/10.1016/j.cortex.2019.09.012CrossRefPubMed

17.

Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 97(20):11050–11055. https://doi.org/10.1073/pnas.200033797CrossRefPubMedPubMedCentral

18.

Fischl B, Salat DH, Busa E et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341–355. https://doi.org/10.1016/s0896-6273(02)00569-xCrossRefPubMed

19.

Reuter M, Rosas HD, Fischl B (2010) Highly accurate inverse consistent registration: a robust approach. Neuroimage 53(4):1181–1196. https://doi.org/10.1016/j.neuroimage.2010.07.020CrossRefPubMed

20.

Ségonne F, Dale AM, Busa E et al (2004) A hybrid approach to the skull stripping problem in MRI. Neuroimage 22(3):1060–1075. https://doi.org/10.1016/j.neuroimage.2004.03.032CrossRefPubMed

21.

Desikan RS, Ségonne F, Fischl B et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3):968–980. https://doi.org/10.1016/j.neuroimage.2006.01.021CrossRefPubMed

22.

Fischl B, van der Kouwe A, Destrieux C et al (2004) Automatically parcellating the human cerebral cortex. Cereb Cortex 14(1):11–22. https://doi.org/10.1093/cercor/bhg087CrossRefPubMed

23.

Westman E, Muehlboeck JS, Simmons A (2012) Combining MRI and CSF measures for classification of Alzheimer’s disease and prediction of mild cognitive impairment conversion. Neuroimage 62(1):229–238. https://doi.org/10.1016/j.neuroimage.2012.04.056CrossRefPubMed

24.

Mendez MF, Shapira JS, Miller BL (2005) Stereotypical movements and frontotemporal dementia. Mov Disord 20(6):742–745. https://doi.org/10.1002/mds.20465CrossRefPubMed

25.

Rohrer JD, Warren JD (2010) Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. J Neurol Sci 293(1–2):35–38. https://doi.org/10.1016/j.jns.2010.03.012CrossRefPubMedPubMedCentral

26.

Wang L, Mathews GC, Whetsell WO et al (2008) Hypermotor seizures in patients with temporal pole lesions. Epilepsy Res 82(1):93–98. https://doi.org/10.1016/j.eplepsyres.2008.07.005CrossRefPubMed

27.

Sheelakumari R, Bineesh C, Varghese T et al (2020) Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia. Brain Imaging Behav 14(5):2004–2011. https://doi.org/10.1007/s11682-019-00150-3CrossRefPubMed

28.

Brugger F, Galovic M, Weder BJ et al (2015) Supplementary motor complex and disturbed motor control—a retrospective clinical and lesion analysis of patients after anterior cerebral artery stroke. Front Neurol 6:1–12. https://doi.org/10.3389/fneur.2015.00209CrossRef

29.

Paus T (2001) Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci 2(6):417–424. https://doi.org/10.1038/35077500CrossRefPubMed

Titel: Changes in motor activity level in individuals with frontotemporal dementia
verfasst von: C. R. A. Silveira
E. Mitchell
M. Restrepo-Martinez
K. Coleman
R. Ruiz-Garcia
E. Finger
Publikationsdatum: 16.04.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 8/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11713-2

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