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Sleep and Breathing

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27.09.2022 | Sleep Breathing Physiology and Disorders • Original Article

Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial

verfasst von: Na Li, Yonghai Zhang, Fan Yang, Huiwen Zhang, Xiaoyang Yu, Kaimei Lu, Jie Wang, Hanxiang Ma, Xinli Ni

Erschienen in: Sleep and Breathing | Ausgabe 3/2023

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Abstract

Purpose

Uvulopalatopharyngoplasty (UPPP) can aggravate lung inflammatory reactions in patients with obstructive sleep apnoea syndrome (OSAS). Dexmedetomidine (Dex) is a selective α-2 adrenoreceptor agonist that can alleviate lung injury. This study was designed to investigate the effects of Dex on oxygenation and inflammatory factors in patients undergoing UPPP in the early perioperative period.

Methods

Patients with OSAS undergoing UPPP were randomly allocated to the Dex Group or Control Group. Arterial blood gas analyses were performed, and the respiratory index (RI) and oxygenation index (OI) were calculated upon entering the operating room (T₀) and immediately after surgery (T₃). The inflammatory factors tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were measured at T₀ and T₃.

Results

A total of 44 patients with OSAS were randomized. There was no significant difference in basic patient characteristics between the two groups. The preoperative RI and OI were not significantly different between the two groups, but they were altered immediately after surgery relative to the corresponding preoperative value (p < 0.05). Compared with the Control Group, the RI was significantly lower at T₃ in the Dex Group (p < 0.001). However, there was no significant difference in the OI between the two groups (p = 0.128). The inflammatory factors TNF-α (p < 0.001) and IL-6 (p = 0.018) were lower, while IL-10 was higher in the Dex Group than in the Control Group (p < 0.001).

Conclusion

Dexmedetomidine can improve the oxygenation and inhibit the inflammatory response in patients undergoing UPPP in the early perioperative period.

Trial registration

The present clinical study has been registered at Clinical Trials under number NCT03612440.

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Titel: Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial
verfasst von: Na Li
Yonghai Zhang
Fan Yang
Huiwen Zhang
Xiaoyang Yu
Kaimei Lu
Jie Wang
Hanxiang Ma
Xinli Ni
Publikationsdatum: 27.09.2022
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-022-02711-1

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Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial