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Japanese Journal of Ophthalmology

Erschienen in:

05.02.2024 | Clinical Investigation

Levofloxacin susceptibility of Staphylococci from conjunctiva in patients with atopic dermatitis

verfasst von: Yumi Kusumi, Yoshimasa Ando, Chika Shigeyasu, Masaki Fukui, Masakazu Yamada

Erschienen in: Japanese Journal of Ophthalmology | Ausgabe 2/2024

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Abstract

Purpose

The ocular surface in patients with atopic dermatitis (AD) is known to harbor an abundance of gram-positive cocci, particularly Staphylococcus aureus (S. aureus). This study reviewed the results of microbial cultures from the conjunctiva in AD patients, with special attention to the levofloxacin susceptibility of Staphylococci.

Study design

Retrospective, single-center study.

Methods

This study involved 131 eyes of 112 Japanese patients with AD (87 men and 25 women, mean age: 40.4 ± 12.2 years) who underwent ocular surgery at Kyorin University Hospital. Bacterial isolates were collected from the conjunctival sacs in the preoperative period. Drug resistance to methicillin and levofloxacin was judged using the minimal inhibitory concentrations of oxacillin and levofloxacin determined by the broth dilution method.

Results

One hundred and fifty-seven strains were identified in 103 of the 131 eyes examined. S. aureus was isolated from 74 eyes (56.5%), followed by Staphylococcus epidermidis (S. epidermidis). In S. aureus, 11 strains (14.9%) were methicillin-resistant, and 18 (24.3%) were levofloxacin-resistant. In S. epidermidis, 15 strains (26.8%) were methicillin-resistant, and 17 (30.4%) were levofloxacin-resistant. No significant differences were observed in levofloxacin susceptibility with age, sex, previous ocular surgery, or duration of previous surgery. However, logistic multivariate analysis revealed that levofloxacin-resistant Staphylococci were concurrently resistant to methicillin, suggesting multidrug resistance.

Conclusion

Distinctive bacterial distribution and drug resistance need consideration in the managing of ocular disorders among patients with AD.

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Titel: Levofloxacin susceptibility of Staphylococci from conjunctiva in patients with atopic dermatitis
verfasst von: Yumi Kusumi
Yoshimasa Ando
Chika Shigeyasu
Masaki Fukui
Masakazu Yamada
Publikationsdatum: 05.02.2024
Verlag: Springer Japan
Erschienen in: Japanese Journal of Ophthalmology / Ausgabe 2/2024
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-023-01046-y

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Levofloxacin susceptibility of Staphylococci from conjunctiva in patients with atopic dermatitis

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