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Journal of Neurology

Erschienen in:

02.07.2023 | Review

Serum levels of neurofilament light chains in pediatric multiple sclerosis: a systematic review and meta-analysis

verfasst von: Alexandru-Ştefan Niculae, Lucia-Elena Niculae, Cristiana Văcăraş, Vitalie Văcăraş

Erschienen in: Journal of Neurology | Ausgabe 10/2023

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Abstract

Background

Multiple sclerosis is a neuro-inflammatory disease that affects adults and children and causes somatic and cognitive symptoms. Diagnosis after the first clinical symptoms is challenging, involves laboratory and magnetic resonance imaging work-up and is often inconclusive unless subsequent clinical attacks occur. Neurofilament light chains are structural proteins within neurons. Levels of this marker in cerebrospinal fluid, plasma and serum are consistently higher in patients with an initial clinical demyelinating attack that later go on to develop multiple sclerosis. Evidence concerning serum levels of this biomarker in children with multiple sclerosis is scarce. Our aim is to review and analyze the evidence available for patients with multiple sclerosis, under the age of 18.

Methods

We conducted a systematic search of PubMed/Medline, Embase, Cochrane Database, and ProQuest. Human studies that provided data on serum levels of Neurofilament light chains in pediatric patients with MS, measured at the time of the first demyelinating attack and before treatment were included in meta-analysis.

Results

Three studies satisfied the inclusion criteria. 157 pediatric patients with multiple sclerosis and 270 hospital-based controls that did not present with this condition were included in the analysis. A fixed effects meta-analysis showed that the standardized mean difference between patients and controls is 1.82, with a 95% confidence interval of [1.56–2.08].

Conclusion

Pediatric patients with multiple sclerosis show higher levels of serum neurofilament light chains at their first clinical demyelinating attack compared to pediatric hospital-based controls.

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Titel: Serum levels of neurofilament light chains in pediatric multiple sclerosis: a systematic review and meta-analysis
verfasst von: Alexandru-Ştefan Niculae
Lucia-Elena Niculae
Cristiana Văcăraş
Vitalie Văcăraş
Publikationsdatum: 02.07.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 10/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11841-9

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