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Clinical Autonomic Research
Erschienen in: Clinical Autonomic Research 6/2023

16.11.2023 | REVIEW ARTICLE

The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review

verfasst von: T. J. Pereira, J. Bouakkar, H. Johnston, M. Pakosh, J. D. Drake, H. Edgell

Erschienen in: Clinical Autonomic Research | Ausgabe 6/2023

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Abstract

Purpose

This systematic review aimed to summarize how oral contraceptives (OC) affect resting autonomic function and the autonomic response to a variety of physiological stressors.

Methods

A search strategy was created to retrieve citations investigating physiological responses comparing OC users to non-users (NOC) in response to autonomic reflex activation.

Results

A total of 6148 citations were identified across databases from inception to June 2, 2022, and 3870 citations were screened at the abstract level after deduplication. Then, 133 texts were assessed at full-text level, and only 40 studies met eligibility requirements. Included citations were grouped by the aspect of autonomic function assessed, including autonomic reflex (i.e., baroreflex, chemoreflex, mechanoreflex, metaboreflex, and venoarterial reflex), or indicators (i.e., heart rate variability, pulse wave velocity, and sympathetic electrodermal activity), and physiological stressors that may alter autonomic function (i.e., auditory, exercise, mental or orthostatic stress, altitude, cold pressor test, sweat test, and vasodilatory infusions).

Conclusion

OC influence the physiological responses to chemoreflex, mechanoreflex, and metaboreflex activation. In terms of autonomic indices and physiological stressors, there are more inconsistencies within the OC literature, which may be due to estrogen dosage within the OC formulation (i.e., heart rate variability) or the intensity of the stressor (exercise intensity/duration or orthostatic stress). Further research is required to elucidate the effects of OC on these aspects of autonomic function because of the relatively small amount of available research. Furthermore, researchers should more clearly define or stratify OC use by duration, dose, and/or hormone cycling to further elucidate the effects of OC.
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Literatur
1.
United Nations Department of Economic and Social Affairs, Population Division (2022) World family planning 2022: meeting the changing needs for family planning: contraceptive use by age and method. UN DESA/POP/2022/TR/NO.4.
2.
Welt CK, Pagan YL, Smith PC, Rado KB, Hall JE (2003) Control of follicle-stimulating hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the luteal-follicular transition. J Clin Endocrinol Metab 88:1766–1771PubMedCrossRef
3.
4.
Chiazze L Jr, Brayer FT, Macisco JJ Jr, Parker MP, Duffy BJ (1968) The length and variability of the human menstrual cycle. JAMA 203:377–380PubMedCrossRef
5.
Li H, Gibson EA, Jukic AMZ, Baird DD, Wilcox AJ, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S (2023) Menstrual cycle length variation by demographic characteristics from the Apple Women’s Health Study. NPJ Digit Med 6:100PubMedPubMedCentralCrossRef
6.
7.
Assadpour E, Ivry I, Wasef S, Adeyinka B, Murray KR, Edgell H (2020) Oral contraceptives and menstrual cycle influence autonomic reflex function. Physiol Rep 8:e14550PubMedPubMedCentralCrossRef
8.
Abidi S, Nili M, Serna S, Kim S, Hazlett C, Edgell H (2017) Influence of sex, menstrual cycle, and oral contraceptives on cerebrovascular resistance and cardiorespiratory function during Valsalva or standing. J Appl Physiol (1985) 123:375–386PubMedCrossRef
9.
Nili M, Abidi S, Serna S, Kim S, Edgell H (2017) Influence of sex, menstrual cycle, and oral contraceptives on the cerebrovascular response to paced deep breathing. Clin Auton Res 27:411–415PubMedCrossRef
10.
Novak P (2011) Quantitative autonomic testing. J Vis Exp 19:2502
11.
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097PubMedPubMedCentralCrossRef
12.
Polanin JR, Pigott TD, Espelage DL, Grotpeter JK (2019) Best practice guidelines for abstract screening large-evidence systematic reviews and meta-analyses. Res Synth Methods 10:330–342PubMedCentralCrossRef
13.
Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, Stephenson M, Aromataris E (2020) Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth 18:2127–2133PubMed
14.
15.
Aleknaviciute J, Tulen JHM, De Rijke YB, Bouwkamp CG, van der Kroeg M, Timmermans M, Wester VL, Bergink V, Hoogendijk WJG, Tiemeier H, van Rossum EFC, Kooiman CG, Kushner SA (2017) The levonorgestrel-releasing intrauterine device potentiates stress reactivity. Psychoneuroendocrinology 80:39–45PubMedCrossRef
16.
Barel E, Abu-Shkara R, Colodner R, Masalha R, Mahagna L, Zemel OC, Cohen A (2018) Gonadal hormones modulate the HPA-axis and the SNS in response to psychosocial stress. J Neurosci Res 96:1388–1397PubMedCrossRef
17.
Bishop GD, Brown MD (2007) Cutaneous postural vasoconstriction is modified by exogenous but not endogenous female hormones in young women. Clin Auton Res 17:85–92PubMedCrossRef
18.
de Morais TL, Giribela C, Nisenbaum MG, Guerra G, Mello N, Baracat E, Consolim-Colombo FM (2014) Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age. Eur J Obstet Gynecol Reprod Biol 182:113–117PubMedCrossRef
19.
Gamsakhurdashvili D, Antov MI, Stockhorst U (2021) Sex-hormone status and emotional processing in healthy women. Psychoneuroendocrinology 130:105258PubMedCrossRef
20.
Harvey RE, Hart EC, Charkoudian N, Curry TB, Carter JR, Fu Q, Minson CT, Joyner MJ, Barnes JN (2015) Oral contraceptive use, muscle sympathetic nerve activity, and systemic hemodynamics in young women. Hypertension 66:590–597PubMedCrossRef
21.
Jacob DW, Voshage AM, Harper JL, Limberg JK (2022) Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test. Am J Physiol Heart Circ Physiol 322:H1072–H1079PubMedPubMedCentralCrossRef
22.
Kenny GP, Leclair E, Sigal RJ, Journeay WS, Kilby D, Nettlefold L, Reardon FD, Jay O (2008) Menstrual cycle and oral contraceptive use do not modify postexercise heat loss responses. J Appl Physiol (1985) 105:1156–1165PubMedCrossRef
23.
Kowalczyk WJ, Evans SM, Bisaga AM, Sullivan MA, Comer SD (2006) Sex differences and hormonal influences on response to cold pressor pain in humans. J Pain 7:151–160PubMedCrossRef
24.
Limberg JK, Peltonen GL, Johansson RE, Harrell JW, Kellawan JM, Eldridge MW, Sebranek JJ, Walker BJ, Schrage WG (2016) Greater beta-adrenergic receptor mediated vasodilation in women using oral contraceptives. Front Physiol 7:215PubMedPubMedCentralCrossRef
25.
Merz CJ (2017) Contribution of stress and sex hormones to memory encoding. Psychoneuroendocrinology 82:51–58PubMedCrossRef
26.
Middlekauff HR, Park J, Gornbein JA (2012) Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women. Am J Physiol Heart Circ Physiol 302:H2560-2566PubMedPubMedCentralCrossRef
27.
Milan RC, Plassa BO, Guida HL, de Abreu LC, Gomes RL, Garner DM, Valenti VE (2015) Oral contraceptives attenuate cardiac autonomic responses to musical auditory stimulation: pilot study. Altern Ther Health Med 21:37–43PubMed
28.
Minahan C, O’Neill H, Sikkema N, Joyce S, Larsen B, Sabapathy S (2018) Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise. Physiol Rep 6:e13629PubMedPubMedCentralCrossRef
29.
Nielsen SE, Ahmed I, Cahill L (2014) Post-learning stress differentially affects memory for emotional gist and detail in naturally cycling women and women on hormonal contraceptives. Behav Neurosci 128:482–482PubMedPubMedCentralCrossRef
30.
31.
Nisenbaum MG, de Melo NR, Giribela CR, de Morais TL, Guerra GM, de Angelis K, Mostarda C, Baracat EC, Consolim-Colombo FM (2014) Effects of a contraceptive containing drospirenone and ethinyl estradiol on blood pressure and autonomic tone: a prospective controlled clinical trial. Eur J Obstet Gynecol Reprod Biol 175:62–66PubMedCrossRef
32.
Odutayo A, Cherney D, Miller J, Ahmed SB, Lai V, Dunn S, Pun N, Moineddin R, Hladunewich MA (2015) Transdermal contraception and the renin-angiotensin-aldosterone system in premenopausal women. Am J Physiol Renal Physiol 308:F535-540PubMedCrossRef
33.
Parmar HR, Sears J, Molgat-Seon Y, McCulloch CL, McCracken LA, Brown CV, Sheel AW, Dominelli PB (2018) Oral contraceptives modulate the muscle metaboreflex in healthy young women. Appl Physiol Nutr Metab 43:460–466PubMedCrossRef
34.
Rebelo AC, Verlengia R, Kunz VC, Tamburus NY, Silva de Sá MF, Hirata RD, Cerda A, Hirata MH, da Silva E (2013) Association of estrogen receptor alpha gene polymorphisms with autonomic modulation of heart rate in users and nonusers of oral contraceptives. Contraception 88:183–188PubMedCrossRef
35.
Schueller PO, Feuring M, Sharkova Y, Grimm W, Christ M (2006) Effects of synthetic progestagens on autonomic tone, neurohormones and C-reactive protein levels in young healthy females in reproductive age. Int J Cardiol 111:42–48PubMedCrossRef
36.
Straznicky NE, Barrington VE, Branley P, Louis WJ (1998) A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women. J Hypertens 16:357–368PubMedCrossRef
37.
Takeda R, Hissen SL, Stickford ASL, Fu Q (2021) Impact of oral contraceptives on sympathetic neural and cardiovascular responses during static handgrip to fatigue in healthy women. Clin Auton Res 31:779–781PubMedCrossRef
38.
Usselman CW, Nielson CA, Luchyshyn TA, Gimon TI, Coverdale NS, Van Uum SH, Shoemaker JK (2016) Hormone phase influences sympathetic responses to high levels of lower body negative pressure in young healthy women. Am J Physiol Regul Integr Comp Physiol 311:R957-r963PubMedPubMedCentralCrossRef
39.
Villada C, Hidalgo V, Almela M, Mastorci F, Sgoifo A, Salvador A (2014) Coping with an acute psychosocial challenge: behavioral and physiological responses in young women. PLoS ONE 9:e114640PubMedPubMedCentralCrossRef
40.
Grucza R, Pekkarinen H, Titov EK, Kononoff A, Hänninen O (1993) Influence of the menstrual cycle and oral contraceptives on thermoregulatory responses to exercise in young women. Eur J Appl Physiol Occup Physiol 67:279–285PubMedCrossRef
41.
Rebelo AC, Tamburús N, Salviati M, Celante V, Takahashi A, de Sá MF, Catai A, Silva E (2011) Influence of third-generation oral contraceptives on the complexity analysis and symbolic dynamics of heart rate variability. Eur J Contracept Reprod Health Care 16:289–297PubMedCrossRef
42.
Santos MCS, Rebelo A, Zuttin RS, Cesar M, Catai A, Silva E (2008) Influence of oral contraceptive use on lipid levels and cardiorespiratory responses among healthy sedentary women. Braz J Phys Ther 12:188–194CrossRef
43.
Armbruster D, Strobel A (2022) The heart as judge: association of heart rate variability with moral judgement—a replication study. Biol Psychol 169:108284PubMedCrossRef
44.
Danel DP, Kozak K, Szala A, Kunert-Keil C, Dziedzic-Danel A, Siennicka A (2019) The relationship between the premenstrual syndrome and resting cardiac vagal tone in young healthy females: role of hormonal contraception. Neurophysiology 51:447–454CrossRef
45.
Richalet JP, Lhuissier F, Jean D (2020) Ventilatory response to hypoxia and tolerance to high altitude in women: influence of menstrual cycle, oral contraception, and menopause. High Alt Med Biol 21:12–19PubMedCrossRef
46.
Emmons KM, Weidner G (1988) The effects of cognitive and physical stress on cardiovascular reactivity among smokers and oral contraceptive users. Psychophysiology 25:166–171PubMedCrossRef
47.
O’Brien MW, Al-Hinnawi A, Johns JA, Kimmerly DS (2021) Spontaneous cardiovagal baroreflex sensitivity is unaffected by an acute bout of prolonged sitting: no impact of sex, menstrual phase, or oral contraceptive pill phase. Clin Auton Res 31:783–786PubMedCrossRef
48.
Sims ST, Ware L, Capodilupo ER (2021) Patterns of endogenous and exogenous ovarian hormone modulation on recovery metrics across the menstrual cycle. BMJ Open Sport Exerc Med 7:e001047PubMedPubMedCentralCrossRef
49.
Teixeira AL, Ramos PS, Vianna LC, Ricardo DR (2015) Effects of ovarian hormones and oral contraceptive pills on cardiac vagal withdrawal at the onset of dynamic exercise. PLoS ONE 10:e0119626PubMedPubMedCentralCrossRef
50.
51.
Harrison MF, Anderson P, Miller A, O’Malley K, Richert M, Johnson J, Johnson BD (2013) Oral contraceptive use and acute mountain sickness in South Pole workers. Aviat Space Environ Med 84:1166–1171PubMedCrossRef
52.
Christ M, Seyffart K, Wehling M (1999) Attenuation of heart-rate variability in postmenopausal women on progestin-containing hormone replacement therapy. Lancet 353:1939–1940PubMedCrossRef
53.
Matsumoto T, Ushiroyama T, Morimura M, Moritani T, Hayashi T, Suzuki T, Tatsumi N (2006) Autonomic nervous system activity in the late luteal phase of eumenorrheic women with premenstrual symptomatology. J Psychosom Obstet Gynaecol 27:131–139PubMedCrossRef
54.
Liu H, Yao J, Wang W, Zhang D (2017) Association between duration of oral contraceptive use and risk of hypertension: a meta-analysis. J Clin Hypertens (Greenwich) 19:1032–1041PubMedCrossRef
55.
Dos Santos PA, de Oliveira AM, Alves CQ, Souza Filho CF, Ladeia AMT, Petto J (2022) Renin-angiotensin-aldosterone system in women using combined oral contraceptive: a systematic review. Rev Bras Ginecol Obstet 44:710–718PubMedPubMedCentralCrossRef
56.
Nabeel PM, Kiran VR, Joseph J, Abhidev VV, Sivaprakasam M (2020) Local pulse wave velocity: theory, methods, advancements, and clinical applications. IEEE Rev Biomed Eng 13:74–112PubMedCrossRef
57.
Mehta JH, Williams GW 2nd, Harvey BC, Grewal NK, George EE (2017) The relationship between minute ventilation and end tidal CO2 in intubated and spontaneously breathing patients undergoing procedural sedation. PLoS ONE 12:e0180187PubMedPubMedCentralCrossRef
58.
Usselman CW, Luchyshyn TA, Gimon TI, Nielson CA, Van Uum SH, Shoemaker JK (2013) Hormone phase dependency of neural responses to chemoreflex-driven sympathoexcitation in young women using hormonal contraceptives. J Appl Physiol (1985) 115:1415–1422PubMedCrossRef
59.
Mortensen SP, Askew CD, Walker M, Nyberg M, Hellsten Y (2012) The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function. J Physiol 590:4391–4400PubMedPubMedCentralCrossRef
60.
Turner CG, Stanhewicz AE, Nielsen KE, Otis JS, Feresin RG, Wong BJ (2023) Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans. J Appl Physiol (1985) 134:858–867PubMedCrossRef
61.
Foster PS, Goldie RG, Paterson JW (1983) Effect of steroids on beta-adrenoceptor-mediated relaxation of pig bronchus. Br J Pharmacol 78:441–445PubMedPubMedCentralCrossRef
62.
Wenner MM, Haddadin AS, Taylor HS, Stachenfeld NS (2013) Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. J Physiol 591:2345–2355PubMedPubMedCentralCrossRef
63.
Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H (2004) Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res 95:798–806PubMedCrossRef
64.
Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J, Joyner MJ (2011) Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors. J Physiol 589:5285–5297PubMedPubMedCentralCrossRef
65.
Herrera AY, Faude S, Nielsen SE, Locke M, Mather M (2019) Effects of hormonal contraceptive phase and progestin generation on stress-induced cortisol and progesterone release. Neurobiol Stress 10:100151PubMedPubMedCentralCrossRef
66.
Carter JR, Klein JC, Schwartz CE (2010) Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women. Am J Physiol Regul Integr Comp Physiol 298:R9-r14PubMedCrossRef
67.
Rogers SM, Baker MA (1997) Thermoregulation during exercise in women who are taking oral contraceptives. Eur J Appl Physiol Occup Physiol 75:34–38PubMedCrossRef
68.
Charkoudian N, Johnson JM (1997) Modification of active cutaneous vasodilation by oral contraceptive hormones. J Appl Physiol (1985) 83:2012–2018PubMedCrossRef
69.
Leicht AS, Hirning DA, Allen GD (2003) Heart rate variability and endogenous sex hormones during the menstrual cycle in young women. Exp Physiol 88:441–446PubMedCrossRef
70.
Zalewski P, Slomko J, Zawadka-Kunikowska M (2018) Autonomic dysfunction and chronic disease. Br Med Bull 128:61–74PubMedCrossRef
Metadaten
Titel
The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review
verfasst von
T. J. Pereira
J. Bouakkar
H. Johnston
M. Pakosh
J. D. Drake
H. Edgell
Publikationsdatum
16.11.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 6/2023
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-023-00996-0

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