nach oben

Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

08.12.2022 | Other Articles

A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments

verfasst von: Saurav Sarkar, Samapika Routhray, Balamurugan Ramadass, Pradipta Kumar Parida

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Sonderheft 1/2023

Einloggen, um Zugang zu erhalten

Abstract

Introduction: Commensal bacteria have always played a significant role in the maintenance of health and disease but are being unravelled only recently. Studies suggest that the nasal microbiome has a significant role in the development of various disease conditions. Search engines were used for searching articles having a nasal microbiome and disease correlation. In olfactory dysfunction, dysbiosis of the microbiome may have a significant role to play in the pathogenesis. The nasal microbiome influences the phenotype of CRS and is also capable of modulating the immune response and plays a role in polyp formation. Microbiome dysbiosis has a pivotal role in the development of Allergic Rhinitis; but, yet known how is this role played. The nasal microbiome has a close association with the severity and phenotype of asthma. They contribute significantly to the onset, severity, and development of asthma. The nasal microbiome has a significant impact on the immunity and protection of its host. The nasal microbiome has been a stimulus in the development of Otitis Media and its manifestations. Studies suggest that the resident nasal microbiome is responsible for the initiation of neurodegenerative diseases like Parkinson’s Disease.Materials and Methods: Literature search from PubMed, Medline, and Google with the Mesh terms: nasal microbiome AND diseases. Conclusion: With increasing evidence on the role of the nasal microbiome on various diseases, it would be interesting to see how this microbiome can be modulated by pro/pre/post biotics to prevent a disease or the severity of illness.

Noecker C, McNally CP, Eng A, Borenstein E (2017) High-resolutioncharacterization of the human microbiome. Transl Res 179:7–23PubMedCrossRef

Desrosiers M, Valera FC (2019) Brave New (Microbial) World: implications for nasal and sinus disorders. Braz JOtorhinolaryngol 85:675–677CrossRef

Barko PC, McMichael M, Swanson KS, Williams DA (2018) The gastrointestinal microbiome: a review. J Vet Intern Med 32:9–25PubMedCrossRef

9.Gupta VK, Paul S, Dutta C, Geography (2017) Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity. Front Microbiol 8:1162 Published 2017 Jun 23. doi:https://doi.org/10.3389/fmicb.2017.01162CrossRefPubMedPubMedCentral

de Steenhuijsen Piters WAA, Sanders EAM, Bogaert D (2015) The role of the local microbial ecosystem in respiratory health and disease. Philos Trans R Soc B Biol Sci 370:20140294. https://doi.org/10.1098/rstb.2014.0294CrossRef

Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB (2015) The microbiome and the respiratory tract. Annu Rev Physiol 78:481–504. doi: https://doi.org/10.1146/annurev-physiol-021115-105238CrossRefPubMedPubMedCentral

Lighthart B (2000) Mini-review of the concentration variations found in the alfresco atmospheric bacterial populations. https://link.springer.com/content/pdf/10.1023%2FA%3A1007694618888.pdf. Accessed 22 Oct 2018

Copeland E, Leonard K, Carney R, Kong J, Forer M, Naidoo Y et al (2018) Chronic rhinosinusitis: Potential role of microbial dysbiosis and recommendations for sampling sites. Front Cell Infect Microbiol 8:57. https://doi.org/10.3389/fcimb.2018.00057CrossRefPubMedPubMedCentral

Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A et al (2011) Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med 184:957–963. doi: https://doi.org/10.1164/rccm.201104-0655OCCrossRefPubMedPubMedCentral

10.

Martin C, Burgel PR, Lepage P, Andrejak C, de Blic J, Bourdin A et al (2015) Host-microbe interactions in distal airways: relevance to chronic airway diseases. Eur Respir Rev 24:78–91. doi: https://doi.org/10.1183/09059180.00011614CrossRefPubMedPubMedCentral

11.

de Steenhuijsen Piters WA, Huijskens EG, Wyllie AL, Biesbroek G, van den Bergh MR, Veenhoven RH et al (2016) Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients. ISME J 10:97–108. doi: https://doi.org/10.1038/ismej.2015.99CrossRefPubMed

12.

Yi H, Yong D, Lee K, Cho YJ, Chun J (2014) Profiling bacterial community in upper respiratory tracts. BMC Infect Dis 14:583. doi: https://doi.org/10.1186/s12879-014-0583-3CrossRefPubMedPubMedCentral

13.

Stearns JC, Davidson CJ, McKeon S, Whelan FJ, Fontes ME, Schryvers AB et al (2015) Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age. ISME J 9:1246–1259. doi: https://doi.org/10.1038/ismej.2014.250CrossRefPubMedPubMedCentral

14.

Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL et al (2013) Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med 187:1067–1075. doi: https://doi.org/10.1164/rccm.201210-1913OCCrossRefPubMedPubMedCentral

15.

Allen EK, Koeppel AF, Hendley JO, Turner SD, Winther B, Sale MM (2014) Characterization of the nasopharyngeal microbiota in health and during rhinovirus challenge. Microbiome 2:22. doi: https://doi.org/10.1186/2049-2618-2-22CrossRefPubMedPubMedCentral

16.

Botero LE, Delgado-Serrano L, Cepeda ML, Bustos JR, Anzola JM, Del Portillo P et al (2014) Respiratory tract clinical sample selection for microbiota analysis in patients with pulmonary tuberculosis. Microbiome 2:29. doi: https://doi.org/10.1186/2049-2618-2-29CrossRefPubMedPubMedCentral

17.

Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB et al (2015) Spatial variation in the healthy human lung microbiome and the adapted Island model of lung biogeography. Ann Am Thorac Soc 12:821–830. doi: https://doi.org/10.1513/AnnalsATS.201501-029OCCrossRefPubMedPubMedCentral

18.

Tarabichi Y, Li K, Hu S, Nguyen C, Wang X, Elashoff D et al (2015) The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles. Microbiome 3:74. doi: https://doi.org/10.1186/s40168-015-0133-2CrossRefPubMedPubMedCentral

19.

Wood Jones F (1939) The anterior superior alveolar nerve and vessels. J Anat 73:583–591

20.

Mellert TK, Getchell ML, Sparks L, Getchell TV (1992) Characterization of the immune barrier in human olfactory mucosa. Otolaryngol Head Neck Surg 106:181–188PubMedCrossRef

21.

Sahin-Yilmaz A, Naclerio RM (2011) Anatomy and physiology of the upper airway. Proc Am Thorac Soc 8:31–39. https://doi.org/10.1513/pats.201007-050RNCrossRefPubMed

22.

Kimmelman CP (1993) Clinical review of olfaction. Am J Otolaryngol 14:227–239. https://doi.org/10.1016/0196-0709(93)90065-FCrossRefPubMed

23.

Wegener B-A, Croy I, Hähner A, Hummel T (2018) Olfactory training with older people. Int J Geriatr Psychiatry 33:212–220. https://doi.org/10.1002/gps. 4725CrossRef

24.

Pekala K, Chandra RK, Turner JH (2016) Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. Int Forum Allergy Rhinol 6:299–307. https://doi.org/10.1002/alr.21669CrossRefPubMed

25.

Koskinen K, Reichert JL, Hoier S, Schachenreiter J, Duller S, Moissl-Eichinger C et al (2018) The nasal microbiome mirrors and potentially shapes olfactory function. Sci Rep 8:1–11CrossRef

26.

François A, Grebert D, Rhimi M, Mariadassou M, Naudon L, Rabot S et al (2016) Olfactory epithelium changes in germfree mice. Sci Rep 6:24687. https://doi.org/10.1038/srep24687CrossRefPubMedPubMedCentral

27.

Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R (2009) Bacterial community variation in human body habitats across space and time. Science 326:1694–1697. https://doi.org/10.1126/science.1177486CrossRefPubMedPubMedCentral

28.

Jones N (2001) The nose and paranasal sinuses physiology and anatomy. Adv Drug Deliv Rev 51:5–19. https://doi.org/10.1016/S0169-409X(01)00172-7CrossRefPubMed

29.

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC et al (2009) Topographical and temporal diversity of the human skin microbiome. Science 324:1190–1192. https://doi.org/10.1126/science.1171700CrossRefPubMedPubMedCentral

30.

Liu CM, Price LB, Hungate BA, Abraham AG, Larsen LA, Christensen K et al (2015) Staphylococcus aureus and the ecology of the nasal microbiome. Sci Adv 1. https://doi.org/10.1126/sciadv.1400216

31.

Ramakrishnan VR, Hauser LJ, Frank DN (2016) The sinonasal bacterial microbiome in health and disease. Curr Opin Otolaryngol Head Neck Surg 24:20–25. https://doi.org/10.1097/MOO.0000000000000221CrossRefPubMedPubMedCentral

32.

Bosch AATM, Levin E, van Houten MA, Hasrat R, Kalkman G, Biesbroek G et al (2016) Development of upper respiratory tract microbiota in infancy is affected by mode of delivery. EBioMedicine 9:336–345. https://doi.org/10.1016/j.ebiom.2016.05.031 M4 - CitaviCrossRefPubMedPubMedCentral

33.

Lécuyer H, Audibert J, Bobigny A, Eckert C, Jannière-Nartey C, Buu-Hoï A et al (2007) Dolosigranulum pigrum causing nosocomial pneumonia and septicemia. J Clin Microbiol 45:3474–3475. https://doi.org/10.1128/JCM. 01373–07CrossRefPubMedPubMedCentral

34.

Jain R, Hoggard M, Biswas K, Zoing M, Jiang Y, Douglas R (2017) Changes in the bacterial microbiome of patients with chronic rhinosinusitis after endoscopic sinus surgery. Int Forum Allergy Rhinol 7:7–15. https://doi.org/10.1002/alr.21849CrossRefPubMed

35.

Kern RC (2009) Candidate’s Thesis: Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope. ;110:1071–7

36.

Hornung DE (2006) Nasal anatomy and the sense of smell. Adv Otorhinolaryngol 63:1–22PubMed

37.

Brook I, Gober AE (2005) Recovery of potential pathogens in the nasopharynx of healthy and otitis media-prone children and their smoking and nonsmoking parents. Ann Otol Rhinol Laryngol 117:727–730CrossRef

38.

Brook I, Gober AE (2007) Effect of smoking cessation on the microbial flora. Arch Otolaryngol Head Neck Surg 133:135–138. https://doi.org/10.1001/archotol.133.2.135CrossRefPubMed

39.

Boutin S, Graeber SY, Weitnauer M, Panitz J, Stahl M, Clausznitzer D et al (2015) Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis. PLoS ONE 10:1–19. https://doi.org/10.1371/journal.pone.0116029CrossRef

40.

Fodor AA, Klem ER, Gilpin DF, Elborn JS, Boucher RC, Tunney MM et al (2012) The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations. PLoS ONE 7:e4500CrossRef

41.

Prevaes SMPJ, De Steenhuijsen Piters WAA, De Winter-De Groot KM, Janssens HM, Tramper-Stranders GA, Chu MLJN et al (2017) Concordance between upper and lower airway microbiota in infants with cystic fibrosis. Eur Respir J 49. https://doi.org/10.1183/13993003.02235-2016

42.

Parkins MD, Floto RA (2015) Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis. J Cyst Fibros 14:293–304. https://doi.org/10.1016/j.jcf.2015.03.012CrossRefPubMed

43.

Tracy M, Cogen J, Hoffman LR (2015) The pediatric microbiome and the lung. Curr Opin Pediatr 27:348–355. https://doi.org/10.1097/MOP. 0000000000000212CrossRefPubMedPubMedCentral

44.

Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S et al (2015) Lung microbiota across age and disease stage in cystic fibrosis. Sci Rep 5:10241. https://doi.org/10.1038/srep10241CrossRefPubMedPubMedCentral

45.

105, Whiteson KL, Bailey B, Bergkessel M, Conrad D, Delhaes L, Felts B et al (2014) The upper respiratory tract as a microbial source for pulmonary infections in cystic fibrosis. Parallels from island biogeography. Am J Respir Crit Care Med 189:1309–1315. https://doi.org/10.1164/rccm.201312-2129PPCrossRef

46.

Frayman KB, Armstrong DS, Grimwood K, Ranganathan SC (2017) The airway microbiota in early cystic fibrosis lung disease. Pediatr Pulmonol 52:1384–1404PubMedCrossRef

47.

Goss CH, Muhlebach MS, Review (2011) Staphylococcus aureus and MRSA in cystic fibrosis. J Cyst Fibros 10:298–306. https://doi.org/10.1016/j.jcf.2011.06.002CrossRefPubMed

48.

Tiddens HAWM, Stick SM, Davis S (2014) Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomography. Paediatr Respir Rev 15:92–97. https://doi.org/10.1016/j.prrv.2013.05.003CrossRefPubMed

49.

Abreu NA, Nagalingam NA, Song Y, Roediger FC, Pletcher SD, Goldberg AN et al (2012) Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med 4:151ra124. https://doi.org/10.1126/scitranslmed.3003783CrossRefPubMedPubMedCentral

50.

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F et al (2012) EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinol J 50:1–12. https://doi.org/10.4193/Rhino50E2CrossRef

51.

Foreman A, Jervis-Bardy J, Wormald P-J (2011) Do biofilms contribute to the initiation and recalcitrance of chronic rhinosinusitis? Laryngoscope 121:1085–1091. https://doi.org/10.1002/lary.21438CrossRefPubMed

52.

Mahdavinia M, Keshavarzian A, Tobin MC, Landay A, Schleimer RP (2016) A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS). Clin Exp Allergy 46:21–41. https://doi.org/10.1111/cea.12666CrossRefPubMedPubMedCentral

53.

Shin S, Ponikau J, Sherris D, Congdon D, Frigas E, Homburger H et al (2004) Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol 114:1369–1375PubMedCrossRef

54.

Bachert C, Gevaert P, van Cauwenberge P (2002) Staphylococcus aureus enterotoxins: a key in airway disease? Allergy 57:480–487PubMedCrossRef

55.

Rawls M, Ellis AK (2019) The microbiome of the nose. Ann Allergy Asthma Immunol 122(1):17–24PubMedCrossRef

56.

Desrosiers M (2004) Refractory chronic rhinosinusitis: pathophysiology and management of chronic rhinosinusitis persisting after endoscopic sinus surgery. Curr Allergy Asthma Rep 4(3):200–207PubMedCrossRef

57.

Hoggard M, Waldvogel-Thurlow S, Zoing M, Chang K, Radcliff FJ, Wagner Mackenzie B et al (2018) Inflammatory endotypes and microbial associations in chronic rhinosinusitis. Front Immunol 9:2065. https://doi.org/10.3389/fimmu.2018.02065CrossRefPubMedPubMedCentral

58.

Choi E-B, Hong S-W, Kim D-K, Jeon SG, Kim K-R, Cho S-H et al (2014) Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis. Allergy 69:517–526. https://doi.org/10.1111/all.12374CrossRefPubMed

59.

Wagner Mackenzie B, Waite DW, Hoggard M, Douglas RG, Taylor MW, Biswas K (2017) Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environ Microbiol 19:381–392. https://doi.org/10.1111/1462-2920.13632CrossRefPubMed

60.

Psaltis AJ, Wormald P-J (2017) Therapy of sinonasal microbiome in CRS: a critical approach. Curr Allergy Asthma Rep 17:59. https://doi.org/10.1007/s11882-017-0726-xCrossRefPubMed

61.

Dlugaszewska J, Leszczynska M, Lenkowski M, Tatarska A, Pastusiak T, Szyfter W (2016) The pathophysiological role of bacterial biofilms in chronic sinusitis. Eur Arch Otorhinolaryngol 273:1989–1994. https://doi.org/10.1007/s00405-015-3650-5CrossRefPubMed

62.

Stephenson M-F, Mfuna L, Dowd SE, Wolcott RD, Barbeau J, Poisson M et al (2010) Molecular characterization of the polymicrobial flora in chronic rhinosinusitis. J Otolaryngol Head Neck Surg. ;39:182–7 http://www.ncbi.nlm.nih.gov/pubmed/20211106. Accessed 16 Oct 2018

63.

Ramakrishnan VR, Hauser LJ, Feazel LM, Ir D, Robertson CE, Frank DN (2015) Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome. J Allergy Clin Immunol 136:334–42e1. https://doi.org/10.1016/J.JACI.2015.02.008CrossRefPubMed

64.

Hoggard M, Biswas K, Zoing M, Wagner Mackenzie B, Taylor MW, Douglas RG (2017) Evidence of microbiota dysbiosis in chronic rhinosinusitis. Int Forum Allergy Rhinol 7:230–239. https://doi.org/10.1002/alr.21871CrossRefPubMed

65.

Hirschberg A, Kiss M, Kadocsa E, Polyanka H, Szabo K, Razga Z et al (2016) Different activations of toll-like receptors and antimicrobial peptides in chronic rhinosinusitis with or without nasal polyposis. Eur Arch Otorhinolaryngol 273:1779–1788. https://doi.org/10.1007/s00405-015-3816-1CrossRefPubMed

66.

Aurora R, Chatterjee D, Hentzleman J, Prasad G, Sindwani R, Sanford T (2013) Contrasting the microbiomes from healthy volunteers and patients with chronic rhinosinusitis. JAMA Otolaryngol Neck Surg 139:1328. https://doi.org/10.1001/jamaoto.2013.5465CrossRef

67.

Chalermwatanachai T, Vilchez-Vargas R, Holtappels G, Lacoere T, Jáuregui R, Kerckhof F-M Chronic rhinosinusitis with nasal polyps is characterized Kumpitsch BMC Biology et al (2019) 17:87 Page 17 of 20 by dysbacteriosis of the nasal microbiota. Sci Rep. 2018;8:7926. https://doi.org/10.1038/s41598-018-26327-2

68.

Bhattacharyya N, Kepnes LJ (2008) Assessment of trends in antimicrobial resistance in chronic rhinosinusitis. Ann Otol Rhinol Laryngol 117(6):448–452PubMedCrossRef

69.

Kingdom TT, Swain RE Jr (2004) The microbiology and antimicrobial resistance patterns in chronic rhinosinusitis. Am J Otolaryngol 25(5):323–328PubMedCrossRef

70.

Nadel DM, Lanza DC, Kennedy DW (1998) Endoscopically guided cultures in chronic sinusitis. Am J Rhinol 12(4):233–241PubMedCrossRef

71.

Coffey CS, Sonnenburg RE, Melroy CT, Dubin MG, Senior BA (2006) Endoscopically guided aerobic cultures in postsurgical patients with chronic rhinosinusitis. Am J Rhinol 20(1):72–76PubMedCrossRef

72.

Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN (2012) Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope 122(2):467–472PubMedCrossRefPubMedCentral

73.

Lal D, Keim P, Delisle J, Barker B, Rank MA, Chia N et al (2017) Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects. Int Forum Allergy Rhinol 7:561–569. https://doi.org/10.1002/alr.21934CrossRefPubMed

74.

Kuhar HN, Tajudeen BA, Mahdavinia M, Heilingoetter A, Ganti A, Gattuso P et al (2018) Relative abundance of nasal microbiota in chronic rhinosinusitis by structured histopathology. Int Forum Allergy Rhinol. https://doi.org/10.1002/alr.22192CrossRefPubMed

75.

Workman AD, Brooks SG, Kohanski MA, Blasetti MT, Cowart BJ, Mansfield C et al (2018) Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis. J Allergy Clin Immunol Pract 6:1078–1080PubMedCrossRef

76.

Patel NN, Workman AD, Cohen NA (2018) Role of taste receptors as sentinels of innate immunity in the upper airway. J Pathog 2018:9541987PubMedCrossRefPubMedCentral

77.

Naraghi M, Deroee AF, Ebrahimkhani M, Kiani S, Dehpour A (2007) Nitric oxide: a new concept in chronic sinusitis pathogenesis B. Am J Otolaryngol 28:334–337PubMedCrossRef

78.

Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L et al (2014) Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 124:1393–1405PubMedCrossRefPubMedCentral

79.

Carey RM, Workman AD, Hatten KM, Siebert AP, Brooks SG, Chen B et al (2017) Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes. Int Forum Allergy Rhinol 7:699–704PubMedCrossRefPubMedCentral

80.

Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW et al (2017) Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol 6:783–791CrossRef

81.

Cope EK, Goldberg AN, Pletcher SD, Lynch SV (2017) Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences. Microbiome 5(1):53PubMedCrossRefPubMedCentral

82.

KeithPK DesrosiersM, LaisterT, SchellenbergRR WasermanS (2012) The burden of allergic rhinitis (AR) in Canada: Perspectives of physicians and patients. Allergy Asthma Clin Immunol 8(1):7CrossRef

83.

BenningerMS BenningerRM (2009) The impact of allergic rhinitis on sexual activity, sleep, and fatigue. Allergy Asthma Proc.; 30(4):358–365

84.

Choi CH, PoroykoV WatanabeS et al (2014) Seasonal allergic rhinitis affects sinonasal microbiota. AmJRhinolAllergy 28(4):281–286

85.

Sjogren YM, Jenmalm MC, Bottcher MF, Bjorksten B, Sverremark-Ekstrom E (2009) Altered early infant gut microbiota in children developing allergy upto 5 years of age. Clin Exp Allergy 39(4):518–526PubMedCrossRef

86.

Foliaki S, Pearce N, Bjorkst B et al (2009) Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: Interna-tional Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol 124(5):982–989PubMedCrossRef

87.

Ruokolainen L, Paalanen L, Karkman A et al (2017) Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia. Clin Exp Allergy 47(5):665–674PubMedCrossRef

88.

Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N et al (2015) The infant airway microbiome in health and disease impacts later asthma development. Cell Host Microbe 17:704–715. https://doi.org/10.1016/j.chom.2015.03.008CrossRefPubMedPubMedCentral

89.

Huang YJ, Boushey HA (2015) The microbiome in asthma. J Allergy Clin Immunol 135(1):25–30PubMedCrossRefPubMedCentral

90.

Perez-Losada M, Alamri L, Crandall KA, Freishtat RJ (2017) Nasopharyngeal microbiome diversity changes over time in children with asthma. PLoS ONE 12(1):e0170543PubMedCrossRefPubMedCentral

91.

Perez-Losada M, Crandall KA, Freishtat RJ (2016) Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children. Microbiome 4(1):25PubMedCrossRefPubMedCentral

92.

Dickson RP, Erb-Downward JR, Huffnagle GB (2013) The role of the bacterial microbiome in lung disease. Exp Rev Respir Med 7(3):245–257CrossRef

93.

Perez-Losada M, Castro-Nallar E, Bendall ML, Freishtat RJ, Crandall KA (2015) Dual transcriptomic profiling of host and microbiota during health and disease in pediatric asthma. PLoS ONE 10(6):e0131819PubMedCrossRefPubMedCentral

94.

Fazlollahi M, Lee TD, Andrade J et al (2018) The nasal microbiome in asthma. J Allergy Clin Immunol 142(3):834–843e832PubMedCrossRefPubMedCentral

95.

Perez-Losada M, Authelet KJ, Hoptay CE, Kwak C, Crandall KA, Freishtat RJ (2018) Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas. Microbiome 6(1):179PubMedCrossRefPubMedCentral

96.

Abt MC, Osborne LC, Monticelli LA et al (2012) Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37(1):158–170PubMedCrossRefPubMedCentral

97.

Ichinohe T, Pang IK, Kumamoto Y et al (2011) Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A 108(13):5354–5359PubMedCrossRefPubMedCentral

98.

Levy M, Blacher E, Elinav E (2017) Microbiome, metabolites and host immunity. Curr Opin Microbiol 35:8–15PubMedCrossRef

99.

Lee KH, Gordon A, Shedden K et al (2019) The respiratory microbiome and susceptibility to influenza virus infection. PLoS ONE 14(1):e0207898PubMedCrossRefPubMedCentral

100.

Lynch SV (2014) Viruses and microbiome alterations. Ann Am Thorac Soc 11(Suppl 1):S57–S60PubMedCrossRef

101.

Lee KH, Gordon A, Foxman B (2016) The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspective. Evol Med Public Health 2016(1):95–109PubMedCrossRefPubMedCentral

102.

Cauley LS, Vella AT (2015) Why is coinfection with influenza virus and bacteria so difficult to control? Discov Med 19(102):33–40PubMedPubMedCentral

103.

Salk HM, Simon WL, Lambert ND et al (2016) Taxa of the nasal microbiome are associated with influenza-specific IgA response to live attenuated influenza vaccine. PLoS ONE 11(9):e0162803PubMedCrossRefPubMedCentral

104.

De Lastours V, Malosh R, Ramadugu K et al (2016) Co-colonization by Streptococcus pneumoniae and Staphylococcus aureus in the throat during acute respiratory illnesses. Epidemiol Infect 144(16):3507–3519PubMedCrossRef

105.

Short KR, Habets MN, Hermans PW, Diavatopoulos DA (2012) Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship? Future Microbiol 7(5):609–624PubMedCrossRef

106.

Borges L, Giongo A, Pereira LM et al (2018) Comparison of the nasopharynx microbiome between influenza and non influenza cases of severe acute respiratory infections: A pilot study. Health Sci Rep 1(6):e47PubMedCrossRefPubMedCentral

107.

Wen Z, Xie G, Zhou Q et al (2018) Distinct nasopharyngeal and oropharyngeal microbiota of children with influenza A virus compared with healthy children. BioMed Res Int. ; 2018: 6362716

108.

McCullers JA, McAuley JL, Browall S, Iverson AR, Boyd KL, Henriques Normark B (2010) Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets. J Infect Dis 202(8):1287–1295PubMedCrossRef

109.

Rosas-Salazar C, Shilts MH, Tovchigrechko A et al (2016) Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy. J Infect Dis 214(12):1924–1928PubMedCrossRefPubMedCentral

110.

Fan RR, Howard LM, Griffin MR et al (2016) Nasopharyngeal pneumococcal density and evolution of acute respiratory illnesses in young children, Peru, 2009–2011. Emerg Infect Dis 22(11):1996–1999PubMedCrossRefPubMedCentral

111.

Wolter N, Tempia S, Cohen C et al (2014) High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia. J Infect Dis 210(10):1649–1657PubMedCrossRef

112.

Toivonen L, Camargo CA Jr, Gern JE et al (2019) Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis. J Allergy Clin Immunol 143(5):1925–1928e7PubMedCrossRefPubMedCentral

113.

Mansbach JM, Hasegawa K, Piedra PA et al (2018) Haemophilus-dominant nasopharyngeal microbiota is associated with delayed clearance of respiratory syncytial virus in infants hospitalized for bronchiolitis. J Infect Dis 219(11):1804–1808CrossRefPubMedCentral

114.

Wertheim HF, Melles DC, Vos MC et al (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5(12):751–762PubMedCrossRef

115.

van de KroneCL K, Trzcinski K, Sanders EA, Bogaert D (2014) Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions. Lancet Respir Med 2(2):141–153CrossRef

116.

Bogaert D, De Groot R, Hermans PW (2004) Streptococcus pneumoniae colonization: the key to pneumococcal disease. Lancet Infect Dis 4(3):144–154PubMedCrossRef

117.

Hilty M, Qi W, Brugger SD et al (2012) Nasopharyngeal microbiota in infants with acute otitis media. J Infect Dis 205(7):1048–1055PubMedCrossRef

118.

Laufer AS, Metlay JP, Gent JF, Fennie KP, Kong Y, Pettigrew MM (2011) Microbial communities of the upper respiratory tract and otitis media in children. mBio 2(1):e00245–e00210PubMedCrossRefPubMedCentral

119.

Lappan R, Imbrogno K, Sikazwe C et al (2018) A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera. BMC Microbiol 18(1):13PubMedCrossRefPubMedCentral

120.

Chonmaitree T, Jennings K, Golovko G et al (2017) Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media. PLoS ONE 12(7):e0180630PubMedCrossRefPubMedCentral

121.

Béraud D, Maguire-Zeiss KA (2012) Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson’s disease. Parkinsonism Relat Disord 18(Supplement 1):17–20. https://doi.org/10.1016/S1353-8020(11)70008-6CrossRef

122.

Friedland RP (2015) Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J Alzheimer’s Dis 45:349–362CrossRef

123.

Khan F, Oloketuyi SF (2016) A future perspective on neurodegenerative diseases: nasopharyngeal and gut microbiota. J Appl Microbiol 122:306–320PubMedCrossRef

124.

Mulak A, Bonaz B (2015) Brain-gut-microbiota axis in Parkinson’s disease. World J Gastroenterol 21:10609–10620. https://doi.org/10.3748/wjg.v21.i37.10609CrossRefPubMedPubMedCentral

125.

Haehner A, Boesveldt S, Berendse HW, Mackay-Sim A, Fleischmann J, Silburn PA et al (2009) Prevalence of smell loss in Parkinson’s disease - a multicenter study. Park Relat Disord 15:490–494. https://doi.org/10.1016/j.parkreldis.2008.12.005CrossRef

126.

Pereira PAB, Aho VTE, Paulin L, Pekkonen E, Auvinen P, Scheperjans F (2017) Oral and nasal microbiota in Parkinson’s disease. Park Relat Disord 38:61–67. https://doi.org/10.1016/j.parkreldis.2017.02.026CrossRef

127.

Hawkes CH, Del Tredici K, Braak H (2007) Parkinson’s disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol 33:599–614PubMedCrossRefPubMedCentral

Titel: A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments
verfasst von: Saurav Sarkar
Samapika Routhray
Balamurugan Ramadass
Pradipta Kumar Parida
Publikationsdatum: 08.12.2022
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe Sonderheft 1/2023
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-022-03205-y

Neu im Fachgebiet HNO

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

29.05.2024 Hörstörungen Nachrichten

Hört jemand im Alter schlecht, nimmt das Hirn- und Hippocampusvolumen besonders schnell ab, was auch mit einem beschleunigten kognitiven Abbau einhergeht. Und diese Prozesse scheinen sich unabhängig von der Amyloidablagerung zu ereignen.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments

Abstract

Neu im Fachgebiet HNO

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

Update HNO

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Sonderheft 1/2023

Cochlear Implantation Outcomes in Pediatrics with Inner Ear Malformations in a Tertiary Care Hospital in Ahvaz

A Rare Case Report of an Acute Orbit

Posterior Ethmomaxillary Cells: Anatomical Variation to be Considered in Endoscopic Sinus Surgery

A Study of Round Window and its Adjacent Anatomy to Guide the Cochlear Implant Electrode Insertion

Relationship Between Lipid Profile and Sensorineural Hearing Loss: An Institution Based Study

Acute Otitis Media with Intracranial and Intratemporal Complications: A Case Study

Neu im Fachgebiet HNO

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

Update HNO